English Journal

Nakase I, Kogure K, Harashima H, Futaki S.SourceInstitute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2011;683:525-33.
To enhance the cytosolic delivery of therapeutic drugs and genes, pH-sensitive and membrane fusiogenic peptides have been employed as additives for facilitating their endosomal escape. GALA is such a peptide composed of repeating sequences of Glu-Ala-Leu-Ala, which are designed to mimic the function
PMID 21053154

Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion.

Brender JR, Hartman K, Gottler LM, Cavitt ME, Youngstrom DW, Ramamoorthy A.SourceDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Biophysical journal.Biophys J.2009 Nov 4;97(9):2474-83.
In previous in vivo studies, amyloid fibers formed from a peptide ubiquitous in human seminal fluid (semen-derived enhancer of viral infection (SEVI)) were found to dramatically enhance the infectivity of the HIV virus (3-5 orders of magnitude by some measures). To complement those studies, we perfo
PMID 19883590