フマリルアセト・酸

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/24 10:19:03」(JST)

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1. チロシン代謝障害 disorders of tyrosine metabolism
2. 全身疾患と関連した遺伝性ニューロパチー hereditary neuropathies associated with generalized disorders
3. 肝細胞移植 hepatocyte transplantation
4. ALA脱水酵素欠損性ポルフィリン症 ala dehydratase porphyria
5. 新生児胆汁うっ滞の原因 causes of neonatal cholestasis

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma.

Feng T1, Dzieran J1, Gu X2, Marhenke S3, Vogel A3, Machida K4, Weiss TS5, Ruemmele P6, Kollmar O7, Hoffmann P8, Grässer F8, Allgayer H9, Fabian J1, Weng HL1, Teufel A10, Maass T10, Meyer C1, Lehmann U11, Zhu C12, Mertens PR12, Gao CF2, Dooley S1, Meindl-Beinker NM1.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Jun;128(11):761-74. doi: 10.1042/CS20140606.
Transforming growth factor β (TGF-β) is cytostatic towards damage-induced compensatory hepatocyte proliferation. This function is frequently lost during hepatocarcinogenesis, thereby switching the TGF-β role from tumour suppressor to tumour promoter. In the present study, we investigate Smad7 ove
PMID 25602745

Comparative proteomic analysis of melon phloem exudates in response to viral infection.

Serra-Soriano M1, Navarro JA2, Genoves A3, Pallás V4.
Journal of proteomics.J Proteomics.2015 Apr 17;124:11-24. doi: 10.1016/j.jprot.2015.04.008. [Epub ahead of print]
Phloem vasculature is the route that most plant viruses use to spread widely around the plant. In addition, phloem sap transports signals that trigger systemic defense responses to infection. We investigated the proteome-level changes that occur in phloem sap during virus infection using the 2D-DIGE
PMID 25892132

Cloning and expression of fumarylacetoacetate hydrolase derived from marine yeast Rhodosporidium diobovatum.

Liu Y1, Xia W, Yang P, Zhang S, Shi Z, Tang H, Zhang L.
Journal of basic microbiology.J Basic Microbiol.2015 Apr 1. doi: 10.1002/jobm.201400908. [Epub ahead of print]
Fumarylacetoacetate hydrolase (FAH) catalyzes the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield acetoacetate and fumarate as the final step in tyrosine degradation. In this study, the FAH genomic DNA and cDNA of Rhodosporidium. diobovatum were cloned by using the method
PMID 25832819

Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability

Fumarylacetoacetic acid
Names
	IUPAC name (E)-4,6-Dioxooct-2-enedioic acid
	Other names Fumarylacetoacetate
Identifiers
CAS Number	28613-33-4
ChemSpider	4444081
Jmol 3D model	Interactive image
MeSH	Fumarylacetoacetate
PubChem	5280398
	InChI InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+ Key: GACSIVHAIFQKTC-OWOJBTEDSA-N ; InChI=1/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+ Key: GACSIVHAIFQKTC-OWOJBTEDBU ;
	SMILES O=C(\C=C\C(=O)O)CC(=O)CC(=O)O ;
Properties
Chemical formula	C8H8O6
Molar mass	200.15 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references