n.

そばかす、しみ、雀卵斑

WordNet

mark with freckles
a small brownish spot (of the pigment melanin) on the skin (同)lentigo
become freckled; "I freckle easily"
dry (ink) with blotting paper
an act that brings discredit to the person who does it; "he made a huge blot on his copybook" (同)smear, smirch, spot, stain
relating to or covered with or resembling freckles (同)lentiginous, lentiginose

PrepTutorEJDIC

そばかす・しみ / …‘に'そばかす(しみ)を生じさせる / そばかす(しみ)ができる
(特に,インクなどの)汚れ,しみ / (人格・名声などにつけられた)汚点,汚名 / 〈他〉…‘に'しみおつける,'を'汚す / (吸取紙で)…‘の'汚れ(しみ)を吸い取る;〈汚れ・しみ〉'を'吸い取る
黒色症(皮膚や髪に多量の黒い色素の出る病気)
そばかす(しみ)のある

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/18 04:13:55」(JST)

wiki en

[Wiki en表示]

Freckles, sometimes called ephelis, are clusters of concentrated melanin which are most often visible on people with a fair complexion. Freckles do not have an increased number of melanin-producing cells (melanocytes), but instead have cells that overproduce melanin granules changing the coloration of the skin (increased number of melanosomes). This also causes the different skin tones among humans, but contrasts with lentigines and moles.^[1]

Black and white photos show contrast in freckles.

Biology

The formation of freckles is triggered by exposure to sunlight. The exposure to UV-B radiation activates melanocytes to increase melanin production, which can cause freckles to become darker and more visible.

Freckles are predominantly found on the face, although they may appear on any skin exposed to the sun, such as arms or shoulders. Heavily distributed concentrations of melanin may cause freckles to multiply and cover an entire area of skin, such as the face. Freckles are rare on infants, and more commonly found on children before puberty. Upon exposure to the sun, freckles will reappear if they have been altered with creams or lasers and not protected from the sun, but do fade with age in some cases.

Freckles are not a skin disorder, but people with freckles generally have a lower concentration of photo protective melanin, and are therefore more susceptible to the harmful effects of UV radiation. It is suggested that people whose skin tends to freckle should avoid overexposure to sun and use sunscreen.^[2]^[3]

Genetics

The presence of freckles is related to rare alleles of the MC1R gene, though it does not differentiate whether an individual will have freckles if they have one or even two copies of this gene. Also, individuals with no copies of the MC1R do sometimes display freckles. Even so, individuals with a high number freckling sites have one or more of variants of the MC1R gene. Of the variants of the MC1R gene Arg151Cys, Arg160Trp, and Asp294His are the most common in the freckled subjects.^[4]^[5]^[6] The MC1R gene is also associated with red hair more strongly than with freckles. Most red haired individuals have two variants of the MC1R gene and almost all have one.^[5] The variants that cause red hair are the same that cause freckling.^[4] Freckling can also be found in areas, such as Japan, where red hair is not seen. These individuals have the variant Val92Met which is also found in Caucasians although it has minimal effects on their pigmentation. The R162Q allele has a disputed involvement in freckling.^[7]

The variants of the MC1R gene that are linked with freckles started to emerge in the human genotype when humans started to leave Africa. The variant Val92Met arose somewhere between 250,000 - 100,000 years ago, long enough for this gene to be carried by humans into central Asia. Arg160Trp is estimated to have arisen around 80,000 years ago while Arg151Cys and Asp294His have been estimated to arise around 30,000 years ago. The wide variation of the MC1R gene exists in people of European descent because of the lack of strong environmental pressures on the gene.^[8] The original allele of MC1R coded for dark skin with a high melanin content in the cells. The high melanin content is protective in areas of high UV light exposure.^[8] The need was less as humans moved into higher latitudes where incoming sunlight has lower UV light content. The adaptation of lighter skin is needed so that individuals in higher latitudes can still absorb enough UV for the production of vitamin D.^[8] Freckled individuals tend to tan less and have very light skin which would have helped the individuals that expressed these genes absorb vitamin D.

Types of freckles

Ephelides describes a freckle which is flat and light brown or red and fades with reduction of sun exposure. Ephelides are more common in those with light complexions, although they are found on people with a variety of skin tones. The regular use of sunblock can inhibit their development.

Liver spots (also known as sun spots and lentigines) look like large freckles, but they form after years of exposure to the sun. Liver spots are more common in older people.

References

Citations

^ Robbins and Cotran Pathologic Basis of Disease Elsevier. 2005. Page 1232. ISBN 0-8089-2302-1 .
^ Hanson Kerry M.; Gratton Enrico; Bardeen Christopher J. (2006). "Sunscreen enhancement of UV-induced reactive oxygen species in the skin". Free Radical Biology and Medicine 41 (8): 1205–12. doi:10.1016/j.freeradbiomed.2006.06.011. PMID 17015167.
^ Garland C, Garland F, Gorham E (1992). "Could sunscreens increase melanoma risk?". Am J Public Health 82 (4): 614–5. doi:10.2105/AJPH.82.4.614. PMC 1694089. PMID 1546792.
^ ^a ^b Flanagan, N., et al. (2000). "Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation." Human Molecular Genetics 9(17): 2531-2537.
^ ^a ^b Bastiaens, M., et al. (2001). "The melanocortin-1-receptor gene is the major freckle gene." Human Molecular Genetics 10(16): 1701-1708.
^ Box, Neil F., David L. Duffy, Rachel E. Irving, Anne Russell, Wei Chen, Lyn R. Griffyths, Peter G. Parsons, Adele C. Green, and Richard A. Sturm. 2001. "Melanocortin-1 Receptor Genotype is a Risk Factor for Basal and Squamous Cell Carcinoma." Journal Of Investigative Dermatology 116, no. 2: 224-229. Academic Search Premier, EBSCOhost (accessed March 3, 2015).
^ Yamaguchi, Kyoko, Chiaki Watanabe, Akira Kawaguchi, Takehiro Sato, Izumi Naka, Misaki Shindo, Keiichi Moromizato, Kenichi Aoki, Hajime Ishida, and Ryosuke Kimura. 2012. "Association of melanocortin 1 receptor gene (MC1R) polymorphisms with skin reflectance and freckles in Japanese." Journal Of Human Genetics 57, no. 11: 700-708. Academic Search Premier, EBSCOhost (accessed March 3, 2015)
^ ^a ^b ^c Harding, R. M., et al. (2000). "Evidence for variable selective pressures at MC1R." American Journal of Human Genetics 66(4): 1351-1361.

Bibliography

Millington GWM (2006). "Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors". Clin Exp Dermatol 31 (3): 407–412. doi:10.1111/j.1365-2230.2006.02128.x. PMID 16681590.

External links

MedicineNet.com: Freckles
Ephelides (Freckles) at eMedicine

UpToDate Contents

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Wang H, Bright A, Xin B, Bockoven JR, Paller AS.SourceDDC Clinic for Special Needs Children, Middlefield, Ohio; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio; Rainbow Babies & Children's Hospital, Cleveland, Ohio; Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio. wang@ddcclinic.org.
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Giant transient pustular melanosis in an infant.

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Japanese Journal

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Related Pictures

★リンクテーブル★

リンク元	「斑点」「しみ」「blot」「雀卵斑」「melanism」
拡張検索	「Hutchinson's melanotic freckle」「pigmented freckle」「Hutchinson melanotic freckle」

「斑点」

Freckle
	Slight facial freckles on a child.
Classification and external resources
Specialty	Dermatology
ICD-10	L81.2
ICD-9-CM	709.09
OMIM	266300
eMedicine	article/1119293
MeSH	D008548