frappe

WordNet

liqueur poured over shaved ice
thick milkshake containing ice cream
take up the slack of; "frap a rope"
make secure by lashing; "frap a sail"

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(飲物,特にワインが)少し冷えた / フラッペ((1)かき氷にリキュール・ワインなどをかけた飲物(2)果汁をなかば凍らせたもの)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/10 03:11:42」(JST)

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English Journal

PK evaluation of fondaparinux sodium for the treatment of thrombosis.

Delavenne X, Frappé P, Zufferey P, Mismetti P, Laporte S, Bertoletti L.Author information Université Jean Monnet, EA3065 , F-42023 Saint-Etienne , France.AbstractIntroduction: Fondaparinux sodium (pentasaccharide) was the first of a new class of antithrombotic agents developed for the prevention and treatment of venous thromboembolism (VTE), blocking thrombin generation by selectively inhibiting factor Xa. Areas covered: This review focuses on the currently available information evaluating the pharmacokinetics, pharmacodynamics, clinical efficacy and safety of fondaparinux in the prevention and treatment of VTE and treatment of acute coronary syndromes (ACS). Expert opinion: Fondaparinux is an alternative to low-molecular-weight heparins (LMWH) for thromboprophylaxis in various clinical settings (major orthopedic surgery of the lower limbs, major abdominal surgery, immobilized medical patients at high risk of VTE), as well as for the treatment of VTE (deep venous thrombosis, pulmonary embolism). It is currently challenged, in the context of both surgical thromboprophylaxis and acute VTE treatment, by the new oral anticoagulants. Fondaparinux remains the sole drug validated in patients with isolated superficial vein thrombosis of the lower limbs, and at prophylactic doses is a good alternative to LMWH at anticoagulant doses for patients with ACS, especially those ineligible for percutaneous coronary intervention.
Expert opinion on drug metabolism & toxicology.Expert Opin Drug Metab Toxicol.2013 Dec 21. [Epub ahead of print]
Introduction: Fondaparinux sodium (pentasaccharide) was the first of a new class of antithrombotic agents developed for the prevention and treatment of venous thromboembolism (VTE), blocking thrombin generation by selectively inhibiting factor Xa. Areas covered: This review focuses on the currently
PMID 24359588

Long-lasting, experience-dependent alcohol preference in Drosophila.

Peru Y Colón de Portugal RL, Ojelade SA, Penninti PS, Dove RJ, Nye MJ, Acevedo SF, Lopez A, Rodan AR, Rothenfluh A.Author information Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA; Program in Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.AbstractTo understand the molecular and neural mechanisms underlying alcohol addiction, many models ranging from vertebrates to invertebrates have been developed. In Drosophila melanogaster, behavioral paradigms from assaying acute responses to alcohol and to behaviors more closely modeling addiction have emerged in recent years. However, both the CAFÉ assay, similar to a two-bottle choice consumption assay, as well as conditioned odor preference, where ethanol is used as the reinforcer, are labor intensive and have low throughput. To address this limitation, we have established a novel ethanol consumption preference assay, called FRAPPÉ, which allows for fast, high throughput measurement of consumption in individual flies, using a fluorescence plate reader. We show that naïve flies do not prefer to consume ethanol, but various pre-exposures, such as ethanol vapor or voluntary ethanol consumption, induce ethanol preference. This ethanol-primed preference is long lasting and is not driven by calories contained in ethanol during the consumption choice. Our novel experience-dependent model of ethanol preference in Drosophila-a highly genetically tractable organism-therefore recapitulates salient features of human alcohol abuse and will facilitate the molecular understanding of the development of alcohol preference.
Addiction biology.Addict Biol.2013 Oct 29. doi: 10.1111/adb.12105. [Epub ahead of print]
To understand the molecular and neural mechanisms underlying alcohol addiction, many models ranging from vertebrates to invertebrates have been developed. In Drosophila melanogaster, behavioral paradigms from assaying acute responses to alcohol and to behaviors more closely modeling addiction have e
PMID 24164972

Tiotropium Respimat inhaler and the risk of death in COPD.

Wise RA, Anzueto A, Cotton D, Dahl R, Devins T, Disse B, Dusser D, Joseph E, Kattenbeck S, Koenen-Bergmann M, Pledger G, Calverley P; TIOSPIR Investigators.Collaborators (1319)Bocca X, Casas J, Defranchi H, Elias P, Fernández M, Figueroa S, Giugno E, Mannarino S, Marzoratti L, Medina A, Nogueira J, Olmo R, Rodriguez A, Rojas R, Salvo M, Wehbe L, Yañez A, Fogarty P, Holmes M, Langton D, Phillips M, Southcott A, Veale A, Ablinger O, Sweilem M, Voves R, Balthazar Y, Beutels M, De Meulemeester M, Decramer M, Devresse Y, Eykerman T, Maury O, Vereecken G, Weckx J, Adalberto R, Dias R, Fiss E, Jardim J, Lastebasse F, Losso L, Lundgren F, Maranhao B, Mello D, Pizzichini E, Studart F, Waldo L, Dancheva A, Dimitrov V, Dimitrova R, Dimova D, Hodzhev V, Kostov K, Osmanliev D, Palaveev K, Popov D, Simeonova M, Stefanova B, Youroukova V, Amer E, Bailey A, Bayly K, Bell A, Bouchard J, Boucher P, Braidy J, Cox G, Craig B, Dattani D, Dhar A, Dowell A, Ervin F, Fera T, Field S, FitzGerald M, Fox G, Gauthier J, Goldstein R, Goulet S, Hart R, Henein S, Ho K, Hodder R, Homik L, Houle P, Kanawaty D, Kaplan A, Kelly A, Killian K, Killorn P, Lachance P, Lam S, Landry D, Lasko B, Leech J, Luton R, Marciniuk D, Mayers I, Michael R, Nayar A, O'Donnell D, O'Keefe D, O'Mahony M, O'Mahony W, Palayew M, Ralph S, Ramesh W, Rizvi Q, Rolf D, Sharma A, Tytus R, Zidel B, Bai C, Cai S, Chen G, Chen P, Chen P, Cui S, Gao Z, Ge G, Hu C, Huang J, Huang M, Huang W, Huang Y, Jiang H, Li J, Li Y, Lin Y, Liu C, Liu J, Liu Y, Luo Z, Sun X, Tang Y, Wan H, Wang H, Wen Z, Wu C, Wu Y, Xiao Z, Xin J, Yang J, Ying K, Yu W, Zhang J, Zhao L, Zhao Z, Zhong X, Zhou J, Zhou X, Cardona G, Giraldo H, Isaza D, Matiz C, Tirado C, Bulat L, Glad L, Gluncic T, Gordana P, Gudelj I, Horvat M, Markovic A, Mise K, Pavicic F, Samarzija M, Skrinjaric-Cincar S, Stjepanovic G, Tudoric N, Vrbica Z, Backer V, Brockelmann K, Dahl R, Dolberg M, Dzajic V, Dzajic V, Enk B, Garne S, Hansen M, Jensen G, Johnsen C, Kindt S, Lavik B, Møller A, Nielsen C, Nielsen S, Sørensen T, Titlestad I, Ekroos H, Elo J, Hakulinen A, Kotaniemi J, Pusa L, Rantala T, Strander I, Abenhaim N, Aroun J, Auré P, Baranes C, Bayle P, Beaurain C, Bellessort A, Bellvert P, Bettendorf A, Beuzelin D, Biquet D, Bisch O, Blouin P, Boisseau L, Bonneau D, Bortolotti C, Boucher L, Boukhana M, Bourcq P, Boye A, Boyer P, Breton N, Buffard B, Cadinot D, Campagne A, Ceccarelli B, Chaigneau G, Couffin Y, Coutrey L, Daguzan B, Delamare G, Delsart D, Delvallez M, Dillinger J, Ducolone A, Durel G, Dusser D, Ferrier R, Fivel C, Frappé T, Garrel E, Goby A, Hasselmann P, Herent M, Hersen B, Humbert T, Jude N, Kellou E, Lacoin F, Lalanne G, Larrousse M, Lauer B, Legendre M, Lejay D, Lemarie B, Leprince P, Lion A, Lopez J, Lousqui C, Mannessier B, Marin D, Marlier M, Marmor P, Martocq G, Meme B, Mercier P, Michellier P, Milosevic D, Molinier J, Moreul J, Mostefai Y, Mouel S, Moulla M, Parent D, Perrin C, Petit D, Peyre E, Pierot E, Pinet C, Pouget M, Remaud P, Richter D, Roger J, Rolle P, Schaupp T, Sebbah A, Specht L, Taminau D, Tardif P, Touzet P, Triot P, Troussier J, Troussier J, Unal J, Verdavoine P, Vogel J, Wurtz J, Zimmermann D, Chumburidze V, Gotua M, Katsarava V, Khintibidze I, Kobulia B, Maglakelidze T, Vacharadze K, Alakmeh H, Althammer G, Babyesiza A, Beck E, Benedix A, Berg P, Berger F, Bert F, Bettig U, Botzen U, Büttner C, Deckelmann R, Degtyareva E, Dichmann R, Dorsch W, Eckhard J, Eilers A, Entzian P, Erdle W, Feimer J, Feldmeyer F, Feußner W, Förster K, Franz K, Frick H, Fritzsche A, Gams W, Gehling U, Geßner C, Ginko T, Glatzel D, Grill D, Grimm-Sachs V, Gröschel W, Groß B, Großkopf W, Groth G, Groth J, Gummert A, Günsberg K, Hector H, Heinz G, Hennig R, Hering H, Hofbauer P, Hoffmann M, Hofmann S, Hoheisel G, Höltz S, Hoppe G, Hüting R, Jasch B, Jezek M, Junggeburth J, Kampschulte J, Kannieß F, Käßner F, Kehm S, Kestermann O, Kirschner J, Kleinecke-Pohl U, Knorr R, Krüll M, Kühne P, Kuschel C, Lammert-Hünger G, Lienert T, Linnhoff A, Luttermann M, Mahlo D, Malek M, Mallinckrodt C, Marten I, Martin H, Mindt S, Mueller H, Naudts I, Nieß A, Patzer D, Pfeuffer H, Pilz M, Pumpe K, Purgaj J, Raack B, Rau W, Redlich R, Reichhardt J, Richter V, Riegel P, Rolke M, Salbach P, Sauer R, Schmidt O, Schmidtmann S, Schmorell B, Schneider H, Schröder-Babo W, Schürmann W, Sebert M, Seiz V, Steffen H, Steinebach I, Stöckle G, Streck E, Stuff K, Stutz P, Talkner F, Trauth H, Van Bodegom P, Venske W, Vorderstrasse W, Waltert M, Weber H, Wehgartner-Winkler S, Weihrich A, Welss C, Werner M, Westerhausen U, Weyland K, Wiederhold C, Wiemer S, Winkelmann E, Winkler J, Zemke K, Ainsworth P, Blagden M, Bodalia B, Britton M, Cahill T, Ellery A, Gooding T, Halpin D, Middleton A, Nordstrom M, Turner W, Antoniadis A, Bousmoukilia S, Christodoulou M, Gaga M, Ganavias L, Georgatou-Papageorgiou E, Kakoura M, Kallergis K, Katsoulis K, Kokkinis F, Salesiotou V, Siafakas N, Tatsis G, Vlachogianni E, Diaz O, Echeverria E, Ferriño A, López J, Moralejo J, Morales G, Yoc E, Andrasofszky Z, Balint B, Banvolgyi A, Bartha A, Borhy M, Breining I, Csontos Z, Czebe K, Czompo M, Farago K, Györi Z, Jedlinszki M, Kiraly Z, Kosztyu N, Kuberka Z, Major K, Nagy A, Obbagy V, Rakvács M, Somfay A, Szalai Z, Szantai G, Szarka I, Szentesi M, Szolnoki E, Tamas G, Varga A, Varga A, Varga A, Vekony I, Visy K, Balki A, Jagannath K, Khippal N, Malpani A, Manish K, Nandagopal V, Pradyut W, Promod N, Raj G, Ravindra R, Rhijwani P, Srikanth K, Swarnakar R, Whig J, Healy J, Lane S, McElvaney G, McLaughlin G, Mulloy E, O'Brien A, O'Brien D, O'Doherty B, Adir Y, Breuer R, Fink G, Kramer M, Lieberman D, Schwarz Y, Shitrit D, Weiler Z, Anzalone G, Benedetto F, Berra D, Bonavia M, Calabrese C, Carlone S, Casalini A, Donno M, Dottorini M, Ferrara G, Gulotta C, Ligia G, Marassi E, Marsico S, Maselli R, Mastroberardino M, Ottanelli R, Pasqua F, Pela R, Perra R, Pesci A, Pistolesi M, Salis S, Santelli G, Steinhilber G, Tassi G, Torchio R, Valente S, Zanon P, Zucchi L, Choi B, Chung H, In K, Jeong S, Kim K, Kim S, Kim Y, Lee H, Lee J, Lee K, Lee S, Lee Y, Lim S, Moon H, Oh Y, Park C, Rhee Y, Shim J, Shin K, Son C, Yoo C, Yum H, Babjoniseva A, Bukovskis M, Gersamija A, Harasimjukas D, Iesalniece R, Kakurina N, Krams A, Lapkovska Z, Lozovskis V, Petersone A, Davoliene I, Griskeviciene V, Kiziela A, Matukiene V, Naudziunas S, Susinskiene D, Vaicius D, Valius L, Volosevic T, Harun R, How S, Ismail T, Khaira K, Mahayiddin A, Pang Y, Razali N, Tarekh N, Alcalá D, Castañón J, Chavarria U, Corona M, Posadas R, Ramirez A, Servin-Diaz A, Alhakim M, Amin A, Coenen P, Feis W, Jong A, van Mierlo H, van Soest J, van Erp W, Van de Walle V, Brockway B, Epton M, Gillies J, Quinn D, Taylor D, Walford E, Ahlqvist J, Arora S, Brunstad O, Dahle R, Ghezai B, Gronert J, Henrichsen S, Jørstad S, Karlsson T, Kristiansen T, Lier P, Myhr L, Tomala T, Guevara E, Lopez M, Noriega L, Antunez J, Chariarse F, Guerreros A, Ore D, Ortega R, Tsukayama M, Viladegut R, Balgos A, Bernardo M, Carlos G, Ferrer M, Germar A, Isidro M, Jorge M, Roa C, Andrzejewski W, Asankowicz-Bargiel B, Batura-Gabryel H, Bortkiewicz J, Brzecki K, Cieslak M, Czerwinska A, Dabrowska M, Dargiewicz A, Dobryniewska M, Filipek K, Firek B, Gawron A, Gorski P, Grzelewska-Rzymowska I, Harat R, Jasieniak-Pinis G, Jassem E, Kalamarz J, Kania G, Karasek E, Komnata K, Kot A, Labij V, Laczynska E, Lis K, Madej A, Madra-Rogacka D, Malosek D, Mordaka R, Mroz R, Nalepa P, Napora P, Pasternak D, Pierzchala W, Piskorz P, Pulka G, Rajtar I, Rybacki C, Sawicki A, Senderska A, Sidorowicz-Bialynicka A, Szelerska-Twardosz H, Szymkowiak J, Trawinska E, Wlodarczyk M, Zurowska-Gebala M, Almeida A, Bárbara C, Bárbara C, Costa R, Guimarães M, Moita J, Póvoa M, Reis A, Simão P, Alexandru T, Andrei L, Apti G, Copaci I, Ibraim E, Leru P, Nitu F, Savu A, Stoenescu R, Toma C, Trailescu A, Alekseeva E, Arkhipovsky V, Barbarash O, Bezlepko A, Boyarkin M, Bukreeva E, Chernyak B, Emelyanov A, Esip V, Fassakhov R, Fedorova O, Galvas N, Gaydar E, Goldin M, Idrisova E, Ignatova G, Ilkovich M, Ivleva A, Khaisheva L, Khamitov R, Komarov G, Korovina O, Kostin V, Krivosheev A, Kukol L, Lashina E, Leshchenko I, Martynenko T, Martynenko V, Motylev I, Nemtsov B, Nonikov V, Ogorodova L, Oleynikov V, Osipenko M, Ovcharenko S, Palyutin S, Pavlishchuk S, Pistraya T, Podzolkov V, Polevtsova G, Popova V, Raspopina N, Romaschok N, Ryzhova I, Shestakova G, Shmelev E, Shuganov E, Shvarts Y, Sidorenko I, Sidorova L, Simanenkov V, Soloviev K, Stitsenko I, Trofimov V, Ushakova S, Vizel A, Zadionchenko V, Zhestkov A, Lazic Z, Milikic M, Rebic P, Sovljanski G, Stankovic I, Svorcan P, Zvezdin B, Frajtova L, Golubov A, Hrebenar S, Jurco P, Kavkova D, Lescisinova H, Mikova V, Plutinsky J, Pribulova E, Rozborilova E, Sarkanova K, Szarazova M, Timurova-Zambova R, Abdool-Gaffar S, Abdullah A, Abdullah I, Bateman E, Bester F, Bruning A, Duvenage C, Jansen J, Joubert J, O'Brien J, Ras G, Richards J, Richter D, Van Rensburg H, Agüero R, Villar-Álvarez F, Barreiro B, Heredia-Budó JL, Pastor-Esplá E, Pérez-Fernández A, Ferrer A, Sojo-González A, Ausín M, Inchaurraga I, Gutierrez-Lara J, Pérez-de Llano L, Macías E, Ruiz-Manzano J, Llorca-Martinez E, Martínez E, Merino J, Hernández-Mezquita M, Morera J, Blanquer-Olivas R, Santos S, García-Río F, Signes-Costa J, Echave-Sustaeta J, Terns M, Marin-Trigo J, Castillo-Villegas D, Castillo-Vizuete JA, Angesjö E, Barrehag-Vinge I, Bonnevier E, Curiac D, Elfstrand A, Fardelin P, Gunnarsson R, Lagerbäck P, Lundgren M, Paulsson L, Polhem B, Romberg K, Bettschen H, Brack T, Brutsche M, Domenighetti G, Köhler E, Lagler U, Martin H, Matthias P, Paky A, Pons M, Remund K, Russi E, Tamm M, Cheng S, Hang L, Hsiue T, Hsu J, Huang M, Kuo P, Lin C, Lin M, Perng W, Tsai Y, Tsao T, Wang C, Wei Y, Wu C, Bangpattanasiri K, Boonsawat W, Keeratichananont W, Kositsakulchai W, Suntrapiwat K, Beji M, Charfi R, Drira I, Ghedira H, Ghrairi H, Kamel A, Kheder A, Knani J, Maalej S, Rezaiek C, Tritar F, Ardic S, Babayigit C, Caglayan B, Cilli A, Dereli M, Firat I, Gorguner A, Guclu S, Hatipoglu O, Kocabas A, Kosar F, Kurt B, Ozacar R, Polatli M, Saryal S, Sevinc C, Talay F, Turker H, Yetkin O, Amer L, Blazhko V, Dyadyk O, Dzyublyk O, Feshchenko Y, Gavrysyuk V, Godlevska O, Iabluchanskyi M, Iashyna L, Klyaritskaya I, Korzh O, Kovalyova O, Melnyk V, Monogarova N, Mostovoiy Y, Ostrovskyy M, Panina S, Pertseva T, Popik G, Rodionova V, Savchenko V, Shvets N, Smolyanyy O, Soldatchenko S, Sushko V, Vizir V, Voloshyna O, Abel W, Adams K, Ali M, Ali M, Alkins S, Allen G Jr, Altamirano D, Alwine L, Amar S, Andrews C, Apaliski S, Arana J, Arcuri-Kimzey N, Arena C, Armas E, Arora S, Axelrod A, Axler M, Bailey K, Barag S, Barber M, Barker B, Baron M, Barrington P, Bartkowiak A Jr, Basheda S, Bass P 3rd, Bauch T, Beacom M, Beasley R, Beavins J, Beliveau W, Benkert R, Bennett T, Bernstein J, Bhuchar S, Bland V, Blaze K, Block B, Boeren J, Boscia J 3rd, Bowling B, Brautigam D, Bray W, Brewer M, Bricker C, Brodnan J, Brown C, Bruya T, Burk J, Byars W, Castilleja J, Cauthen C, Chen M, Chi W, Chinsky K, Christensen T, Civitarese F, Cohen M, Cohen S, Cohn J, Cole B, Cole J, Colvin D, Condemi J, Conway M, Corder C, Covelli H, Cromer M, Cruz H, Czarnecki M, Dao T, Davis M, Delgado J, DeSantis D, Dexter J, Dobrusin R, Doering G, Donohue J, Dransfield M, Dua R, Dubois L, Dulgeroff A, Dunn L, Earl J, Edmonds L, Eichenhorn M, Elacion J, ElBayadi S, Elias D, Ellis M, Ellison H, Emmans P Jr, Erb D, Ettinger N, Fakih F, Fei R, Feldman G, Fernandez-Medero R, Fitz-Patrick D, Fleming H, Fogarty C, Ford L, Forman J, Fowler W, Fraser N, Friedman P, Fritz S, Gallagher K, Garner A, Goodman D, Gorin A, Graif J, Grant D, Gregory J, Grubb S, Grumley P, Gutmann J, Hammond G, Hampel F Jr, Hanania N, Hansbrough J, Hartley P, Hazan L, Head W, Heitbrink M, Hellems S, Henderson W 4th, Hendrix E, Henkle J, Heyder A, Hill D, Hippert R, Hoekstra J, Hoodin J, House B, Hoyt J, Huling R, Hyers T, Ison R, Jackson T, Jacobs J, Jagminas L, Janes M, Jardula M, Jasper D, Jederlinic P, Jenks D, Jimenez A, Jimenez F, Johnson L, Jones D 4th, Kaelin T, Kahn F, Kahn R, Kaiser H, Kalhan R, Karetzky M, Karpel J, Kemp S, Kessel J, Khan M, Kingsley J, Kleerup E, Knight A, Knutson T, Koser A, Kulback S, Kureishy S, Labuda J 2nd, LaForce C, Laliotis A, Laman P, Landolt C, Lapidus R, Lasala M, Lawlor D, Layish D, Le H, Ledford D, Lee D, Lee H, Lee M, Leeds W, Lemire T, Levinsky D, Lichty C 2nd, Lochner J, Longshaw K, Lucht W, Lynn L, Madsen L, Mahler D, Makam S, Maletz L, Mann J, Marcelin H, Mariglio J, Marinelli A Jr, Marks S, Marple R, Maynard K, Mazdisnian F, McCarthy E, McCartney M, McGettigan J Jr, McGuire M, McNeil D, McNeill R, McNicol D, Mehta K, Melendez-Rivera I, Meli J Jr, Meyers G, Meyers P, Milam M, Millard M, Miller R Jr, Minnick D, Minton S, Mirkil V, Moon E, Moon M, Morales-Ramirez J, Moran J, Moriarty T, Morin S, Morris F, Murray A, Murthy H, Nassery M, Nayak A, Nevins B, Nielsen R, Nissim J, Nussdorfer T, Oelberg D, O'Reilly T, Orr R, Paez H, Palchick B, Parides G, Parrinello J, Paster R, Patel B, Patel N, Patton W, Pearle J, Pearlstein P, Perez J, Perry R, Phillips D, Pieretti M, Pogue B, Pohil R, Pollard S, Popovich K, Porcelli J, Preston B, Pritchett K, Pudi K, Purighalla R, Quigley J, Radow S, Raikhel M, Ramsdell J, Rastogi P, Reddy D, Reddy R, Reichman A, Rice L Jr, Richwine R, Riffel L, Riffer E, Riske T, Rizzo A, Robinette E, Ross S, Rudolph L, Ruoff G, Sachs P, Samson M, Samudrala S, Sandberg J, Sargeant W, Saxman K, Scanlon P, Schachter E, Schelbar E, Schramm E, Schreiman R, Schroeder C, Schul J, Schwartz M, Seibert A, Sensenbrenner J, Sepulveda P, Shandilya L, Shapero P, Shea J, Short D, Sibille J, Siler T, Silverboard H, Silverthorn A, Simon H, Simon S, Singh J, Sippel J, Smith C, Smith K, Solano R, Somerville L, Soong W, Southard J, Spainhour J Jr, Speer J, Spencer W, Spuza-Milord M, Steigman D, Stewart G 3rd, Straughn C, Streit B, Strumillo C, Surowitz R, Tarleton G, Tarshis G, Taylor J, Teltser M, Tita J, Topkis R, Torres D 2nd, Turner M, Updegrove J, Vaela R, Verma S, Viera E, Villareal M, Voelker K, Walthall W, Wanderer A, Wayne J, Weinberg P, Weiss R, Wheatley L, White J, Whitten P, Wilson H Jr, Wiltz O, Winder J, Wine A, Winslow D, Wise R, Wood J, Wood K, Yarows S, Yergin B, Yunger T, Zawadski D, ZuWallack R, Zuzarte K, Anzueto A, Calverley P, Dahl R, Dusser D, Pledger G, Wise R, Corris P, Rudolf M, Schluger N, Turnbull B, Van de Werf F, LaVallee N, Anker S, Browne R, Kempin S, Kowey P, McGarvey L, Magder S, Niewoehner D, Vogelmeier C.
The New England journal of medicine.N Engl J Med.2013 Oct 17;369(16):1491-501. doi: 10.1056/NEJMoa1303342. Epub 2013 Aug 30.
BACKGROUND: Tiotropium delivered at a dose of 5 μg with the Respimat inhaler showed efficacy similar to that of 18 μg of tiotropium delivered with the HandiHaler inhalation device in placebo-controlled trials involving patients with chronic obstructive pulmonary disease (COPD). Although tiotropium
PMID 23992515

[New oral anticoagulants in primary care: The general practitioner's point of view].

Frappé P, Liébart S.Author information Université Jean-Monnet, département de médecine générale, 42023 Saint-Étienne, France; Université Jean-Monnet, groupe de recherche sur la thrombose, EA3065, 42023 Saint-Étienne, France; Inserm/DGOS, CIE3, 42055 Saint-Étienne, France. Electronic address: paul.frappe@univ-st-etienne.fr.AbstractThe assessment of new anticoagulants benefits is based on the assessment of thromboembolism and bleeding risks, referring when possible to CHA2DS2-VASc and HAS-BLED scores. The management of patients treated with new anticoagulants includes a clinical assessment and the annual measure of the creatinine clearance (three times per year in some particular cases). New anticoagulants make hemostasis tests not reliable. The general practitioner has a role in preventing interactions and reporting potential adverse drug reactions. The context of uncertainty about the risk/benefit ratio of new anticoagulants emphasizes the need to integrate the values of the patient in treatment decisions.
Presse médicale (Paris, France : 1983).Presse Med.2013 Sep;42(9 Pt 1):1267-73. doi: 10.1016/j.lpm.2013.06.009. Epub 2013 Jul 31.
The assessment of new anticoagulants benefits is based on the assessment of thromboembolism and bleeding risks, referring when possible to CHA2DS2-VASc and HAS-BLED scores. The management of patients treated with new anticoagulants includes a clinical assessment and the annual measure of the creatin
PMID 23916569

Japanese Journal

あざむかれた人びとの日

言語文化研究 18, 53-73, 2010-12
NAID 110007982132

中世秘跡論争

山形大学紀要. 社会科学 = Bulletin of Yamagata University. Social Science 40(2), 31-65, 2010-02-15
NAID 120005659171

中世秘跡論争

山形大学紀要. 社会科学 40(2), 三十一-六十五, 2010-02-15
NAID 110007572371

レーモン・クノー,パタフィジシアン--『地下鉄のザジ』におけるユーモアの射程

広島大学フランス文学研究 (26), 13-29, 2007
NAID 120000876042

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