ホスフルコナゾール
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/24 19:04:39」(JST)
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Fosfluconazole
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
IV |
| ATC code |
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| Legal status |
| Legal status |
- In general: ℞ (Prescription only)
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| Identifiers |
IUPAC name
- {[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid
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| CAS Number |
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| PubChem CID |
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| ChemSpider |
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| UNII |
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| ChEMBL |
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| Chemical and physical data |
| Formula |
C13H13F2N6O4P |
| Molar mass |
386.25 g/mol |
| 3D model (Jmol) |
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SMILES
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Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3
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InChI
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InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24) Y
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Key:GHJWNRRCRIGGIO-UHFFFAOYSA-N Y
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| NY (what is this?) (verify) |
Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).
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Antifungals (D01 and J02)
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Wall/
membrane |
Ergosterol
inhibitors |
Azoles
(lanosterol 14
alpha-demethylase inhibitors) |
| Imidazoles |
- Topical: bifonazole‡
- butoconazole
- chlormidazole‡
- clotrimazole#
- croconazole‡
- eberconazole
- econazole
- fenticonazole‡
- flutrimazole
- isoconazole‡
- ketoconazole
- luliconazole
- miconazole#
- neticonazole‡
- omoconazole‡
- oxiconazole
- sertaconazole
- sulconazole
- tioconazole
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|
| Triazoles |
- Topical: efinaconazole
- fluconazole#
- fosfluconazole
- terconazole
- Systemic: fluconazole#
- hexaconazole‡
- isavuconazole
- itraconazole
- posaconazole
- voriconazole
- Unknown: albaconazole‡
- ravuconazole†
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| Thiazoles |
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Polyene antimycotics
(ergosterol binding) |
- Topical: hamycin‡
- natamycin
- nystatin#
Systemic: amphotericin B#, hamycin‡
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Squalene monooxygenase
inhibitors |
| Allylamines |
- Topical: naftifine
- terbinafine
Systemic: terbinafine
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| Benzylamines |
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| Others |
|
|
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β-glucan synthase
inhibitors |
- echinocandins (anidulafungin
- biafungin
- caspofungin
- cilofungin
- micafungin)
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| Intracellular |
Pyrimidine analogues/
thymidylate synthase inhibitors |
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| Mitotic inhibitors |
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| Aminoacyl tRNA synthetase inhibitors |
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| Others |
- bromochlorosalicylanilide
- chlorophetanol
- chlorphenesin
- ciclopirox
- crystal violet
- dimazole
- ethylparaben
- haloprogin‡
- polynoxylin
- potassium iodide#
- salicylic acid
- selenium disulfide#
- sodium thiosulfate#
- sulbentine
- taurolidine
- ticlatone
- tolciclate
- tolnaftate
- tribromometacresol
- undecylenic acid
- Whitfield's ointment#
- citronella oil
- lemon grass
- lemon myrtle
- orange oil
- patchouli
- tea tree oil
- PCP: atovaquone
- dapsone
- pentamidine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Pulmonary cryptococcosis presenting with a large cavity.
- Morita S1, Shirai T1, Asada K1, Fujii M1, Suzuki M2, Suda T3.
- Respirology case reports.Respirol Case Rep.2014 Jun;2(2):61-3. doi: 10.1002/rcr2.49. Epub 2014 Feb 25.
- A 78-year-old woman who was receiving corticosteroids for rheumatoid arthritis was admitted to our hospital to have her fever, hemoptysis, diarrhea, and chest x-ray abnormalities, which were unresponsive to antibiotics, investigated. A chest computed tomography scan revealed infiltrative shadows and
- PMID 25473568
- Should prophylactic thrombolysis be routine in clinical practice? Evidence from an autopsy case of septicemia.
- Inai K1, Noriki S, Iwasaki H.
- BMC clinical pathology.BMC Clin Pathol.2014 Jan 30;14(1):6. doi: 10.1186/1472-6890-14-6.
- BACKGROUND: Central venous catheters provide easy access for intravenous infusion and nutrition, but they can bring about complications such as catheter-related infections. Infected central venous catheters often cause nosocomial bloodstream infections with high morbidity and mortality. However, mos
- PMID 24475758
- Disseminated cryptococcosis-induced skin ulcers in a patient with autoimmune hepatitis.
- Ikeda T1, Kaminaka C1, Yamamoto Y1, Furukawa F1.
- Case reports in dermatology.Case Rep Dermatol.2014 Mar 20;6(1):98-102. doi: 10.1159/000360978. eCollection 2014.
- We report the case of a 68-year-old woman with autoimmune hepatitis (AIH) who had leg ulcers induced by disseminated cryptococcosis. She had received prednisolone for her AIH at 20 mg/day for maintenance. On the initial visit, she complained of a painful ulcer that had round, shallow pockets with er
- PMID 24761142
Japanese Journal
- 図説「目で見る薬理学」シリーズ(No.7)抗真菌薬
- 木村 有揮,廣瀬 祥子,西村 富啓 [他]
- 医療 = Japanese journal of National Medical Services : 国立医療学会誌 67(7), 294-298, 2013-07
- NAID 40019786346
- Successful Treatment of Recurrent Candidemia due to Candidal Thrombophlebitis Associated with a Central Venous Catheter Using a Combination of Fosfluconazole and Micafungin
- Hagiya Hideharu,Kajioka Hiroki
- Internal Medicine 52(18), 2139-2143, 2013
- … however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. …
- NAID 130003365820
- 小児の化学療法および造血幹細胞移植での好中球減少期間におけるミカファンギンとホスフルコナゾールによる侵襲性真菌感染症予防の無作為割り付け試験成績
- 澤田 明久,坂田 尚己,樋口 万緑 [他],竹下 泰史,石原 卓,坂田 顕文,興梠 雅彦,近藤 統,小山 真穂,平野 慎也,安井 昌博,井上 雅美,吉岡 章,河 敬世
- 臨床血液 50(12), 1692-1699, 2009-12-30
- NAID 10026331788
Related Links
- Fosfluconazole [F-FLCZ] ホスフルコナゾール, 抗真菌薬 1. 商品名 先発品 プロジフ静注液100／プロジフ静注液200／プロジフ静注液400 【ファイザー】 2. 日本における発売年 2003（平成15）年 3. 特長 フルコナゾールと比べ投与液量が ...
- Fosfluconazole is a medicine available in a number of countries worldwide. A list of US medications equivalent to Fosfluconazole is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on ...
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