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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/24 19:04:39」(JST)

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Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Pulmonary cryptococcosis presenting with a large cavity.

Morita S1, Shirai T1, Asada K1, Fujii M1, Suzuki M2, Suda T3.
Respirology case reports.Respirol Case Rep.2014 Jun;2(2):61-3. doi: 10.1002/rcr2.49. Epub 2014 Feb 25.
A 78-year-old woman who was receiving corticosteroids for rheumatoid arthritis was admitted to our hospital to have her fever, hemoptysis, diarrhea, and chest x-ray abnormalities, which were unresponsive to antibiotics, investigated. A chest computed tomography scan revealed infiltrative shadows and
PMID 25473568

Should prophylactic thrombolysis be routine in clinical practice? Evidence from an autopsy case of septicemia.

Inai K1, Noriki S, Iwasaki H.
BMC clinical pathology.BMC Clin Pathol.2014 Jan 30;14(1):6. doi: 10.1186/1472-6890-14-6.
BACKGROUND: Central venous catheters provide easy access for intravenous infusion and nutrition, but they can bring about complications such as catheter-related infections. Infected central venous catheters often cause nosocomial bloodstream infections with high morbidity and mortality. However, mos
PMID 24475758

Disseminated cryptococcosis-induced skin ulcers in a patient with autoimmune hepatitis.

Ikeda T1, Kaminaka C1, Yamamoto Y1, Furukawa F1.
Case reports in dermatology.Case Rep Dermatol.2014 Mar 20;6(1):98-102. doi: 10.1159/000360978. eCollection 2014.
We report the case of a 68-year-old woman with autoimmune hepatitis (AIH) who had leg ulcers induced by disseminated cryptococcosis. She had received prednisolone for her AIH at 20 mg/day for maintenance. On the initial visit, she complained of a painful ulcer that had round, shallow pockets with er
PMID 24761142

Japanese Journal

図説「目で見る薬理学」シリーズ(No.7)抗真菌薬

木村有揮,廣瀬祥子,西村富啓 [他]
医療 = Japanese journal of National Medical Services : 国立医療学会誌 67(7), 294-298, 2013-07
NAID 40019786346

Successful Treatment of Recurrent Candidemia due to Candidal Thrombophlebitis Associated with a Central Venous Catheter Using a Combination of Fosfluconazole and Micafungin

Hagiya Hideharu,Kajioka Hiroki
Internal Medicine 52(18), 2139-2143, 2013
… however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. …
NAID 130003365820

小児の化学療法および造血幹細胞移植での好中球減少期間におけるミカファンギンとホスフルコナゾールによる侵襲性真菌感染症予防の無作為割り付け試験成績

澤田明久,坂田尚己,樋口万緑 [他],竹下泰史,石原卓,坂田顕文,興梠雅彦,近藤統,小山真穂,平野慎也,安井昌博,井上雅美,吉岡章,河敬世
臨床血液 50(12), 1692-1699, 2009-12-30
NAID 10026331788

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リンク元	「ホスフルコナゾール」

「ホスフルコナゾール」

Fosfluconazole
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name {[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid;
CAS Number	194798-83-9 ;
PubChem CID	214356;
ChemSpider	185843 ;
UNII	3JIJ299EWH;
ChEMBL	CHEMBL1908301 ;
Chemical and physical data
Formula	C13H13F2N6O4P
Molar mass	386.25 g/mol
3D model (Jmol)	Interactive image;
	SMILES Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3 ;
	InChI InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24) ; Key:GHJWNRRCRIGGIO-UHFFFAOYSA-N ;
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英: fosfluconazole
商: プロジフ
関: 抗真菌薬

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fosfluconazole