fosamprenavir calcium

• ホスアンプレナビルカルシウム

関

fosamprenavir、fosamprenavir calcium hydrate、fosamprenavir sodium

WordNet

1. a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20

PrepTutorEJDIC

1. 『カルシウム』(金属元素;化学記号は『Ca』)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/20 22:08:11」(JST)

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[Wiki en表示]

Fosamprenavir

Systematic (IUPAC) name
{[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
Clinical data
Trade names	Lexiva
AHFS/Drugs.com	monograph
MedlinePlus	a604012
Pregnancy category	C (United States)
Legal status	℞-only (U.S.), POM (UK)
Routes of administration	Oral
Pharmacokinetic data
Bioavailability	Unknown
Protein binding	90%
Metabolism	Hydrolysed to amprenavir and phosphate in GI tract epithelium
Biological half-life	7.7 hours
Excretion	Fecal (as metabolites of amprenavir)
Identifiers
CAS Registry Number	226700-81-8 N
ATC code	J05AE07
PubChem	CID: 131536
DrugBank	DB01319 Y
UNII	WOU1621EEG Y
ChEMBL	CHEMBL1664 Y
NIAID ChemDB	082186
Chemical data
Formula	C25H36N3O9PS
Molecular mass	585.608 g/mol 623.700 g/mol (calcium salt)
SMILES O=C(O[C@H]1CCOC1)N[C@@H](Cc2ccccc2)[C@H](OP(=O)(O)O)CN(CC(C)C)S(=O)(=O)c3ccc(N)cc3
InChI InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1 Y Key:MLBVMOWEQCZNCC-OEMFJLHTSA-N Y
N (what is this?)  (verify)

Fosamprenavir (marketed by ViiV Healthcare as the calcium salt), under the trade names Lexiva (U.S.) and Telzir (Europe) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. The FDA approved it October 20, 2003, while the EMEA approved it on July 12, 2004. The human body metabolizes fosamprenavir in order to form amprenavir, which is the active ingredient. That metabolization increases the duration that amprenavir is available, making fosamprenavir a slow-release version of amprenavir and thus reducing the number of pills required versus standard amprenavir.

A head-to-head study with lopinavir showed the two drugs to have comparable potency, but patients on fosamprenavir tended to have a higher serum cholesterol. Fosamprenavir's main advantage over lopinavir is that it is cheaper.

References

UpToDate Contents

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• 1. HIV抗レトロウイルス療法に関する臨床試験：プロテアーゼ阻害剤 clinical trials of hiv antiretroviral therapy protease inhibitors
• 2. HIVプロテアーゼ阻害剤 hiv protease inhibitors
• 3. 抗レトロウイルス療法の潜在的副作用に関するHIV感染患者を対象としたカウンセリング counseling hiv infected patients regarding potential side effects of antiretroviral therapy
• 4. HIV薬剤耐性検査の解釈についての手引 primer on interpretation of hiv drug resistance testing
• 5. 錠剤を嚥下できないHIV感染成人患者の治療：液剤、チュアブル、および砕くことができる剤形の薬剤 treatment of hiv infected adults who have trouble swallowing pills liquid chewable and crushable formulations

English Journal

• Fosamprenavir/ritonavir in patients with viral hepatitis coinfection: an observational multicohort study.

• Nasta P1, Salmon D2, d'Arminio Monforte A3, Pimenta JM4, Cerini C1, Giralda M1, Winnock M5,6, Cozzi-Lepri A7.
• HIV clinical trials.HIV Clin Trials.2016 May;17(3):96-108. doi: 10.1080/15284336.2016.1150409. Epub 2016 Mar 16.
• OBJECTIVE: Safety and tolerability evaluation of adapted dose regimens containing fosamprenavir/ritonavir (FPV/r) in HIV-infected subjects with viral hepatitis co-infection.METHODS: A retrospective multicohort analysis was conducted. Subjects from three European cohorts who started FPV/r or lopinavi
• PMID 27125364

• [Mechanisms of action, pharmacology and interactions of dolutegravir].

• Ribera E1, Podzamczer D2.
• Enfermedades infecciosas y microbiología clínica.Enferm Infecc Microbiol Clin.2015 Mar;33 Suppl 1:2-8. doi: 10.1016/S0213-005X(15)30002-1.
• Dolutegravir is a second-generation integrase strand transfer inhibitor (INSTI), whose potential and binding half-life in the integrase are far superior to those of raltegravir and elvitegravir, conferring it with unique characteristics in terms of its genetic barrier to resistance and activity agai
• PMID 25858605

• Factors related to NT-proBNP levels in HIV patients aged over 40 years.

• Olalla J1, Crespo E1, De la Torre J1, Sempere M2, Del Arco A1, Prada JL1, Malvarez R1, Pérez J1, García-Alegría J1.
• AIDS research and therapy.AIDS Res Ther.2015 May 10;12:17. doi: 10.1186/s12981-015-0058-7. eCollection 2015.
• OBJECTIVE: To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors.METHOD: We determine levels of NT-pro BNP in peripheral blood of HIV patients from Cos
• PMID 25960760

Related Links

• Fosamprenavir - Wikipedia, the free encyclopedia

Fosamprenavir (marketed by ViiV Healthcare as fosamprenavir calcium), under the trade names Lexiva (U.S.) and Telzir (Europe) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. The FDA approved it October 20, 2003 ...

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★リンクテーブル★

リンク元	「ホサンプレナビル」「ホスアンプレナビル」「fosamprenavir sodium」「ホスアンプレナビルカルシウム」
拡張検索	「fosamprenavir calcium hydrate」
関連記事	「fosamprenavir」「calcium」

「ホサンプレナビル」

　　[★]

英

fosamprenavir、fosamprenavir calcium、fosamprenavir sodium、fosamprenavir calcium hydrate

関

ホスアンプレナビル、ホスアンプレナビルカルシウム水和物、ホスアンプレナビルカルシウム、ホスアンプレナビルナトリウム

「ホスアンプレナビル」

　　[★]

英

fosamprenavir、fosamprenavir calcium、fosamprenavir calcium hydrate、fosamprenavir sodium

関

ホサンプレナビル、ホスアンプレナビルカルシウム水和物、ホスアンプレナビルカルシウム、ホスアンプレナビルナトリウム

「fosamprenavir sodium」

　　[★]

• ホスアンプレナビルナトリウム

関

fosamprenavir、fosamprenavir calcium、fosamprenavir calcium hydrate

「ホスアンプレナビルカルシウム」

　　[★]

英

fosamprenavir calcium

関

ホサンプレナビル、ホスアンプレナビル

「fosamprenavir calcium hydrate」

　　[★]

• ホスアンプレナビルカルシウム水和物

関

fosamprenavir、fosamprenavir calcium、fosamprenavir sodium

「fosamprenavir」

　　[★]

ホスアンプレナビル、ホサンプレナビル

関

fosamprenavir calcium、fosamprenavir calcium hydrate、fosamprenavir sodium

同

Lexiva, fos-APV

「calcium」

　　[★]

• カルシウム Ca2+