English Journal

Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-speed counter-current chromatography.

Gao X, Zhuang R, Guo J, Bao J, Fang M, Liu Y, Xu P, Zhao Y.SourceDepartment of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China.
Journal of separation science.J Sep Sci.2010 Feb;33(2):277-84. doi: 10.1002/jssc.200900630.
In this paper, high-speed counter-current chromatography (HSCCC), assisted with ESI-MS, was first successfully applied to the preparative separation of three macrolide antibiotics, brefeldin A (12.6 mg, 99.0%), 7'-O-formylbrefeldin A (6.5 mg, 95.0%) and 7'-O-acetylbrefeldin A (5.0 mg, 92.3%) from th
PMID 20041450

Zhang HW, Cheng HM, Fang H, Zhao YF, Fang MJ.SourceKey Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, Xiamen, China.
Journal of Asian natural products research.J Asian Nat Prod Res.2009;11(1):54-7. doi: 10.1080/10286020802513970.
A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral an
PMID 19177238

Cornella I, Kelly TR.SourceDepartment of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
The Journal of organic chemistry.J Org Chem.2004 Mar 19;69(6):2191-3.
A total synthesis following the sequence in Scheme 1 confirms that porritoxin possesses revised structure 3, not the originally assigned 1. A key reaction was the use of iron pentacarbonyl to formylate an aryllithium when DMF and methyl formate proved insufficiently reactive.
PMID 15058971