巣状糸球体硬化症
- 関
- focal glomerulosclerosis、focal segmental glomerulosclerosis
WordNet
- of or relating to a focus; "focal length"
- having or localized centrally at a focus; "focal point"; "focal infection"
- nephritis marked by inflammation of the glomeruli of the kidney; characterized by decreased production of urine and by the presence of blood and protein in the urine and by edema
PrepTutorEJDIC
- 焦点の
UpToDate Contents
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English Journal
- Oxidized albumin. The long way of a protein of uncertain function.
- Bruschi M, Candiano G, Santucci L, Ghiggeri GM.SourceLaboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Genoa, Italy.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1830(12):5473-9. doi: 10.1016/j.bbagen.2013.04.017. Epub 2013 Apr 22.
- BACKGROUND: Proteins are extremely reactive to oxidants and should represent a potential target of instable reactive oxygen. This may represent a problem for plasma proteins since they may be directly modified in vivo in a compartment where antioxidant enzymatic systems are scarcely represented. On
- PMID 23618696
- Multi-drug resistance-1 gene polymorphisms in nephrotic syndrome: Impact on susceptibility and response to steroids.
- Youssef DM, Attia TA, El-Shal AS, Abduelometty FA.SourcePediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
- Gene.Gene.2013 Nov 10;530(2):201-7. doi: 10.1016/j.gene.2013.08.045. Epub 2013 Aug 27.
- BACKGROUND: Role of multidrug resistance-1 (MDR-1) gene polymorphisms has not been clarified in nephrotic syndrome (NS). Additionally, researchers studied several genetic polymorphisms to explain their influence on different patients' responses to steroid; however the data were inconsistent. Therefo
- PMID 23994685
- A prospective study evaluating the role of donor-specific anti-endothelial crossmatch (XM-ONE assay) in predicting living donor kidney transplant outcome.
- Zitzner JR, Shah S, Jie C, Wegner W, Tambur AR, Friedewald JJ.SourceTransplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Tarry Building, Suite 11-703, Chicago, IL 60611, USA; Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 251 East Huron Street, Galter 3-150, Chicago, IL 60611, USA. Electronic address: j-wehner@northwestern.edu.
- Human immunology.Hum Immunol.2013 Nov;74(11):1431-6. doi: 10.1016/j.humimm.2013.06.007. Epub 2013 Jun 15.
- Anti-endothelial cell antibodies (AECAs) may play a role in allograft rejection. We prospectively tested 150 consecutive living donor kidney transplant recipients, with transplants performed at Northwestern Memorial Hospital between January and December 2010, using the donor-specific endothelial (XM
- PMID 23777928
Japanese Journal
- 各種腎疾患における糸球体細胞外基質成分の免疫組織学的検討
- 千葉 実行
- 日本腎臓学会誌 33(10), 925-938, 1991
- … change nephrotic syndrome (MCNS), 30 mesangial proliferative glomerulonephritis (PGN), 2 focal segmental glomerulosclerosis (FGS), 21 membranous nephropathy (MN), 9 membranoproliferative glomerulonephritis (MPGN), 2 poststreptococcal acute glomerulonephritis (PSAGN), 13 diabetic nephropathy (DN), 16 lupus nephritis (LN), 9 diffuse sclerosing glomerulonephritis (DSGN), 2 amyloid kidney and 1 granulomatous nephropathy in …
- NAID 130004063958
- Long-term prognosis of focal sclerosing glomerulonephritis. An analysis of 250 cases with particular regard to tubulointerstitial changes.
- 甲田 豊
- 日本腎臓学会誌 30(4), 313-329, 1988
- … The glomeruli showing focal and segmental glomerular sclerotic lesions were studied by electron microscopy in 20 patients with glomerulonephritis (GN) (13 with IgA-GN, and 7 with MPGN), 3 with focal glomerular sclerosis, 4 with preeclamptic nephropathy, and 6 with diabetic nephropathy. … The sclerosing lesions in various glomerular deseases showed the following morphological features non-specifically. …
- NAID 130004063875
Related Links
- If you or a loved one has been diagnosed with focal sclerosing glomerulonephritis you probably want to learn more about this condition. This article will discuss what this condition is, its symptoms, causes, diagnosis and treatment.
- I was always told I had urinary reflux when I was born but was finally diagnosed at the age of 9 with Pylonephritis. I don't get why in 2005 when I ... Focal Sclerosing Glomerulonephritis Glomerular disease characterized ...
- [Show abstract] [Hide abstract] ABSTRACT: Morphometrical and clinical investigations were performed in 34 patients with the so-called hypercellular form of focal glomerulosclerosis (FGS), i.e., a form showing clear diffuse mesangial ...
★リンクテーブル★
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- 英
- focal segmental glomerulosclerosis, FSGS, focal and segmental glomerulosclerosis
- 同
- 巣状硬化性糸球体腎炎 focal sclerosing glomerulonephritis
- 関
- 巣状糸球体硬化症 focal glomerulosclerosis, FGS
概念
- 本症は糸球体が巣状かつ分節状に硬化した疾患。
- ネフローゼの20-30%を占める
疫学
症状
成因
- 1. HIV感染、ヘロイン
- 2. 他の糸球体腎炎に続発
- 3. ネフロン喪失に続発するmaladaptation
- 4. 足細胞に発現する細胞骨格に関連する蛋白質(ネフリン)
病理
-
- メサンギウム基質、毛細管腔の閉塞、ヒアリン・脂質滴の沈着
- 蛍光抗体法…IgMと補体成分(特にC3)の沈着が認められる
- 電子顕微鏡…上皮細胞に足突起の融合が見られ、ところどころで上皮細胞そのものが脱落し、基底膜が丸出しになっている所見も認められる
予後
- 予後不良
- ステロイドが効かない
- 腎移植後の再発が多い
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- 焦点の、焦点を通る
- (病変が)限局性の、局所の、病巣の、巣状の
- 関
- circumscribed、definite、focal point、focally、foci、focus、local、localized、locally、nidal、nidus、topical、topically
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- 関
- cirrhotic、sclerogenous、sclerotic
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糸球体腎炎 GN