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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/25 10:44:42」(JST)

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English Journal

  • Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms.
  • Chignalia AZ1, Oliveira MA1, Debbas V2, Dull RO3, Laurindo FR2, Touyz RM4, Carvalho MH1, Fortes ZB1, Tostes RC5.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2015 Jul 1;129(1):39-48. doi: 10.1042/CS20140548.
  • The mechanisms whereby testosterone increases cardiovascular risk are not clarified. However, oxidative stress and inflammation seem to be determinants. Herein, we sought to determine whether exogenous testosterone, at physiological levels, induces leucocyte migration, a central feature in immune an
  • PMID 25700020
  • Two different spectrophotometric determinations of potential anticancer drug and its toxic metabolite.
  • Farid NF1, Abdelwahab NS2.
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Jun 15;145:360-7. doi: 10.1016/j.saa.2015.03.009. Epub 2015 Mar 6.
  • Flutamide is a hormone therapy used for men with advanced prostate cancer. Flutamide is highly susceptible to hydrolysis with the production of 3-(trifluoromethyl)aniline, which is reported to be one of its toxic metabolites, impurities and related substances according to BP and USP. Flutamide was f
  • PMID 25795610
  • PMID 25862351

Japanese Journal

  • A Case of Androgen Receptor-positive Triple Negative Breast Cancer with Good Response to Anti-androgen Therapy
  • The Showa University Journal of Medical Sciences 27(2), 131-136, 2015
  • NAID 130005110365
  • Development of Suppositories Containing Flutamide-Loaded Alginate-Tamarind Microparticles for Rectal Administration: In Vitro and in Vivo Studies
  • 医薬品による毒性発現に係わるオーファン加水分解酵素の機能解明

Related Links

Before taking flutamide, tell your doctor and pharmacist if you are allergic to flutamide or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional ...
Flutamide official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... Flutamide - Clinical Pharmacology General In animal studies, Flutamide ...

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  • 前立腺癌治療剤




  • (成人)フルタミド1回125mg 3T/3 食後 内服


  • 抗腫瘍効果:アンドロゲン依存性前立腺癌細胞の増殖を抑制する
  • フルタミドの主活性代謝物であるOH-フルタミドは200倍の濃度で、ジヒドロテストステロン(アンドロゲンの一種)のアンドロゲンレセプターに対する結合を50%阻害することができる。


  • OH-フルタミドのアンドロゲンレセプターに対するアンドロゲンの結合を阻害する。