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any malignant tumor derived from epithelial tissue; one of the four major types of cancer

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Lu J1, Xia Y1, Chen K1, Zheng Y1, Wang J2, Lu W2, Yin Q3, Wang F1, Zhou Y1, Guo C1.
Oncology letters.Oncol Lett.2016 Jul;12(1):3-10. Epub 2016 May 18.
Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies and the third leading cause of cancer-associated mortality, worldwide. Despite the development of novel therapies, the prognosis of
PMID 27347091

Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.

Riggle KM1,2, Turnham R3,4, Scott JD3,4, Yeung RS1,5, Riehle KJ1,2,5,6.
Pediatric blood & cancer.Pediatr Blood Cancer.2016 Jul;63(7):1163-7. doi: 10.1002/pbc.25970. Epub 2016 Mar 14.
Fibrolamellar hepatocellular carcinoma (FL-HCC) has historically been classified as a rare subtype of HCC. However, unlike "classic" HCC, it occurs in children and young adults without underlying liver disease. The recent discovery of a deletion mutation in all FL-HCCs represented a major advancemen
PMID 26990031

Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.

Riggle KM1, Riehle KJ1,2,3,4, Kenerson HL1, Turnham R5,6, Homma MK5,7, Kazami M1, Samelson B5,6, Bauer R1, McKnight GS6, Scott JD5,6, Yeung RS1,2.
Pediatric research.Pediatr Res.2016 Jul;80(1):110-8. doi: 10.1038/pr.2016.36. Epub 2016 Mar 8.
BACKGROUND: Fibrolamellar hepatocellular carcinoma (FL-HCC) affects children without underlying liver disease. A consistent mutation in FL-HCCs leads to fusion of the genes encoding a heat shock protein (DNAJB1) and the catalytic subunit of protein kinase A (PRKACA). We sought to characterize the re
PMID 27027723

橋口真征,上野真一,迫田雅彦,飯野聡,南幸次,安藤慶,又木雄弘,前村公成,新地洋之,夏越祥次
日本消化器外科学会雑誌 46(11), 822-829, 2013
… 症例は16歳の女性で，肝両葉多発腫瘍（最大径10 cm）を指摘された．画像検査でfibrolamellar hepatocellular carcinoma（以下，FLCと略記）と診断した．肝両葉に10個以上の結節と，肝門部リンパ節転移が疑われたことから，肝動脈化学塞栓療法を2回先行した．しかし，腫瘍が残存していると診断し，手術療法の方針とした．門脈枝塞栓術後に右3区域切除+外側区域腫瘍ラジオ波焼灼術+肝十二指腸間膜内リンパ …
NAID 130004560898

蔵原弘,上野真一,迫田雅彦 [他]
鹿児島大学医学雑誌 62(3), 55-59, 2011-01
… We performed extended left lobectomyof the liver under diagnosis of fibrolamellar hepatocellular carcinoma (FLC). … FLC is rare variant ofhepatocellular carcinoma (HCC) in our country. …
NAID 40018726860

Mediastinal Metastasis from a Fibrolamellar Hepatocellular Carcinoma : Report of a Case

ICHIKI YOSHINOBU,SUGIO KENJI,BABA TETSURO,MIZUKAMI MAKIKO,OGA TAKESHI,TAKENOYAMA MITSUHIRO,HANAGIRI TAKESHI,OKAMOTO KOJI,YAMAGUCHI KOJI,KATAGIRI SATOSHI,YAMAMOTO MASAKAZU,YASUMOTO KOSEI
Surgery today : the Japanese journal of surgery 40(4), 360-364, 2010-04-01
NAID 10027395190