フィブロイン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/07 18:32:30」(JST)
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Fibroin is an insoluble protein created by spiders, the larvae of Bombyx mori, other moth genera such as Antheraea, Cricula, Samia and Gonometa, and numerous other insects. Silk in its raw state consists of two main proteins, sericin and fibroin, with a glue-like layer of sericin coating two singular filaments of fibroin called brins.[1][2]
Primary structure of fibroin, (Gly-Ser-Gly-Ala-Gly-Ala)
n
The fibroin protein consists of layers of antiparallel beta sheets. Its primary structure mainly consists of the recurrent amino acid sequence (Gly-Ser-Gly-Ala-Gly-Ala)n. The high glycine (and, to a lesser extent, alanine) content allows for tight packing of the sheets, which contributes to silk's rigid structure and tensile strength. A combination of stiffness and toughness make it a material with applications in several areas, including biomedicine and textile manufacture.
Fibroin is known to arrange itself in three structures, called silk I, II, and III. Silk I is the natural form of fibroin, as emitted from the Bombyx mori silk glands. Silk II refers to the arrangement of fibroin molecules in spun silk, which has greater strength and is often used in various commercial applications. Silk III is a newly discovered structure of fibroin.[3] Silk III is formed principally in solutions of fibroin at an interface (i.e. air-water interface, water-oil interface, etc.).
Degradation
Many species of Amycolatopsis and Saccharotrix bacteria are able to degrade both silk fibroin and poly(lactic acid).[4]
References
- ^ O. Hakimi et al., “Spider and mulberry silkworm silks as compatible biomaterials”,Composites Part B: Engineering, vol. 38 (3), pp. 324--337, article doi:10.1016/j.compositesb.2006.06.012
- ^ T. Dyakonov et al., “Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug”, Journal of Drug Delivery, vol. 2012 (2012), article ID 490514
- ^ Valluzzi, Regina; Gido, Samuel P.; Muller, Wayne; Kaplan, David L. (1999). "Orientation of silk III at the air-water interface". International Journal of Biological Macromolecules 24 (2-3): 237–242. doi:10.1016/S0141-8130(99)00002-1.
- ^ Yutaka Tokiwa; Buenaventurada P. Calabia; Charles U. Ugwu; Seiichi Aiba (September 2009). "Biodegradability of Plastics". International Journal of Molecular Science 9: 3722–3742. doi:10.3390/ijms10093722. PMC 2769161. PMID 19865515.
English Journal
- Synthesis and cellular compatibility of Co-doped ZnO particles in silk-fibroin peptides.
- Zou Y, Huang Z, Wang Y, Liao X, Yin G, Gu J.SourceCollege of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.
- Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Feb 1;102:29-36. doi: 10.1016/j.colsurfb.2012.08.002. Epub 2012 Aug 11.
- Co-doped ZnO particles were successfully prepared via a facile biomineralization process in the template of silk-fibroin (SF) peptides at room temperature, and SF peptides were coated onto the surface of particles. The ratio of Zn/Co in reactive solution could substantially influence the morphology
- PMID 23010108
- Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction.
- Chi NH, Yang MC, Chung TW, Chou NK, Wang SS.SourceDepartment of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 100 Taiwan, ROC.
- Carbohydrate polymers.Carbohydr Polym.2013 Jan 30;92(1):591-7. doi: 10.1016/j.carbpol.2012.09.012. Epub 2012 Sep 16.
- The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P<0.05) reduced the dilation of th
- PMID 23218340
Japanese Journal
- In Vitro Culture of BMSCs on VEGF-SF-CS Three-Dimensional Scaffolds for Bone Tissue Engineering
- Tong Shuang,Xue Lei,XU Da-peng [他]
- Journal of hard tissue biology 24(2), 123-133, 2015-04
- NAID 40020441647
- LIM-homeodomain transcription factor Awh is a key component activating all three fibroin genes, fibH, fibL and fhx, in the silk gland of the silkworm, Bombyx mori
- Kimoto Mai,Tsubota Takuya,Uchino Keiro,Sezutsu Hideki,Takiya Shigeharu
- Insect biochemistry and molecular biology 56, 29-35, 2015-01
- … In the silkworm Bombyx mori, three fibroin genes, fibroin-heavy-chain (fibH), fibroin-light-chain (fibL) and fibrohexamerin (fhx), are coexpressed only in the posterior silk gland (PSG) cells, while the sericin genes encoding silk glue proteins are expressed in the middle silk gland (MSG) cells. … We investigated whether SGF-2 can activate other fibroin genes using transgenic silkworms. …
- NAID 120005567736
- 玉田 靖,小林 一稔,角 直祐
- 日本シルク学会誌 23(0), 71-73, 2015
- … Silk fibroin, which is recognized as a biocompatible material for use in medical applications, has a long history of use as a surgical suture extending to the present day. … We have developed a novel fabrication process for fibroin sponges. … To use fibroin sponges in medical applications, safety evaluations in a living body must be done. … All tests conducted in this study yielded "negative" results: the fibroin sponge is a safe material for medical applications. …
- NAID 130005066414
Related Links
- MLA style: "fibroin". Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2016. Web. 01 Jun. 2016 < http://www.britannica.com/science/fibroin >. APA style: fibroin. (2016). In Encyclopædia ...
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