English Journal

The Conserved Phenylalanine in the Transmembrane Domain Enhances Heteromeric Interactions of Syndecans.

Kwon MJ1, Park J1, Jang S2, Eom CY2, Oh ES3.
The Journal of biological chemistry.J Biol Chem.2016 Jan 8;291(2):872-81. doi: 10.1074/jbc.M115.685040. Epub 2015 Nov 24.
The transmembrane domain (TMD) of the syndecans, a family of transmembrane heparin sulfate proteoglycans, is involved in forming homo- and heterodimers and oligomers that transmit signaling events. Recently, we reported that the unique phenylalanine in TMD positively regulates intramolecular interac
PMID 26601939

Cell Adhesion Molecules and Stem Cell-Niche-Interactions in the Limbal Stem Cell Niche.

Polisetti N1, Zenkel M1, Menzel-Severing J1, Kruse FE1, Schlötzer-Schrehardt U1.
Stem cells (Dayton, Ohio).Stem Cells.2016 Jan;34(1):203-19. doi: 10.1002/stem.2191. Epub 2015 Sep 11.
Interactions between stem cells and their microenvironment are critical for regulation and maintenance of stem cell function. To elucidate the molecular interactions within the human limbal epithelial stem/progenitor cell (LEPC) niche, which is essential for maintaining corneal transparency and visi
PMID 26349477

Regional specific modulation of the glycocalyx and smooth muscle cell contractile apparatus in conduit arteries of tail-suspended rats.

Kang H1, Fan Y2, Zhao P3, Ren C3, Wang Z3, Deng X3.
Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).2015 Dec 17:jap.00245.2015. doi: 10.1152/japplphysiol.00245.2015. [Epub ahead of print]
The glycocalyx is a key mechanosensor on the surfaces of vascular cells (EC/SMC), and recently, we reported that the redistribution of the hemodynamic factors in tail-suspended (TS) hindlimb-unloaded rats induces the dimensional adaptation of the endothelial glycocalyx in a regional-dependent manner
PMID 26679611