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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/03 21:00:13」(JST)
[Wiki en表示]
Feprazone
|
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| ATC code |
M02AA16 (WHO) |
| Identifiers |
IUPAC name
- 4-(3-methylbut-2-enyl)-1,2-di(phenyl)pyrazolidine-3,5-dione
|
| PubChem (CID) |
35455 |
| ChemSpider |
32612 Y |
| UNII |
7BVX6J0CGR Y |
| KEGG |
D01305 Y |
| ECHA InfoCard |
100.045.735 |
| Chemical and physical data |
| Formula |
C20H20N2O2 |
| Molar mass |
320.385 g/mol |
| 3D model (Jmol) |
Interactive image |
SMILES
-
O=C2N(c1ccccc1)N(C(=O)C2C\C=C(/C)C)c3ccccc3
|
InChI
-
InChI=1S/C20H20N2O2/c1-15(2)13-14-18-19(23)21(16-9-5-3-6-10-16)22(20(18)24)17-11-7-4-8-12-17/h3-13,18H,14H2,1-2H3 Y
-
Key:RBBWCVQDXDFISW-UHFFFAOYSA-N Y
|
| (verify) |
Feprazone (or prenazone) is a drug used for joint and muscular pain.[1]
It is an analog of butazone but instead of a n-butyl group it is prenylated.
References
- ^ Koyama, T.; Izawa, Y.; Wada, H.; Makita, T.; Hashimoto, Y.; Enomoto, M. (1982). "Toxicological aspects of feprazone, a new nonsteroidal anti-inflammatory drug". Toxicology and applied pharmacology. 64 (2): 255–270. doi:10.1016/0041-008X(82)90222-8. PMID 7123554.
|
Topical products for joint and muscular pain (M02)
|
|
Anti-inflammatory
preparations,
non-steroids |
| Pyrazolidines |
- Clofezone
- Mofebutazone
- Oxyphenbutazone
- Phenylbutazone
|
|
Acetic acid
derivatives |
- Diclofenac
- Fentiazac
- Tolmetin
|
|
| Other |
- Bendazac
- Benzydamine
- Bufexamac
- Etofenamate
- Felbinac
- Feprazone
- Flurbiprofen
- Ibuprofen
- Indometacin
- Ketoprofen
- Meclofenamic acid
- Naproxen
- Nifenazone
- Niflumic acid
- Piketoprofen
- Piroxicam
- Suxibuzone
|
|
|
| Capsaicin derivatives |
|
|
| Other |
- Dimethyl sulfoxide
- Idrocilamide
- Tolazoline
|
English Journal
- Fixed drug eruption induced by trimethoprim-sulfamethoxazole: evidence for a link to HLA-A30 B13 Cw6 haplotype.
- Ozkaya-Bayazit E1, Akar U.
- Journal of the American Academy of Dermatology.J Am Acad Dermatol.2001 Nov;45(5):712-7.
- BACKGROUND: Recent reports indicated a significant association between fixed drug eruption (FDE) and HLA class I antigens. A strong correlation was found between B22 antigen and feprazone-induced FDE.OBJECTIVE: Our aim was to investigate the association between HLA class I antigens and FDE in Turkey
- PMID 11606921
- Fixed drug eruptions with feprazone are linked to HLA-B22.
- Pellicano R1, Lomuto M, Ciavarella G, Di Giorgio G, Gasparini P.
- Journal of the American Academy of Dermatology.J Am Acad Dermatol.1997 May;36(5 Pt 1):782-4.
- PMID 9146544
- Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners.
- Lewis DF1, Lake BG.
- Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.1997 May;27(5):443-78.
- 1. The construction of three-dimensional models of CYP2B isozymes from rat (CYP2B1), rabbit (CYP2B4) and man (CYP2B6), based on a multiple sequence alignment with CYP102, a unique eukaryotic-like bacterial P450 (in terms of possessing an NADPH-dependent FAD- and FMN-containing oxidoreductase redox p
- PMID 9179987
Japanese Journal
- Fixed drug eruptions with feprazone are linked to HLA-B22
- Comparison of the Effects of Feprazone and Phenylbutazone on Testosterone Hydroxylations in Mouse Hepatic Microsomes
- Comparison of the effects of feprazone and phenylbutazone on testosterone hydroxylations in mouse hepatic microsomes.
Related Links
- Manus Aktteva Biopharma LLP, a global supplier of Feprazone, 30748-29-9 based in India offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer its ...
- feprazone: Pain and inflammation associated w/ musculoskeletal and joint disorders.. feprazone ... See related feprazone information CIMS Abbreviation Index MIMS Abbreviation Index Indications Pain and ...
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