- 関
- fenoprofen
WordNet
- a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
- a nonsteroidal anti-inflammatory drug (trade name Nalfon) used in the treatment of arthritis and other painful inflammatory disorders (同)fenoprofen_calcium, Nalfon
PrepTutorEJDIC
- 『カルシウム』(金属元素;化学記号は『Ca』)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/02 19:00:34」(JST)
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Fenoprofen
|
Systematic (IUPAC) name |
2-(3-phenoxyphenyl)propanoic acid |
Clinical data |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a681026 |
Pregnancy cat. |
D (US) C |
Legal status |
POM (UK) ℞-only (US) |
Routes |
Oral |
Pharmacokinetic data |
Metabolism |
Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide. |
Half-life |
3 hours |
Excretion |
Renal (~90%) |
Identifiers |
CAS number |
29679-58-1 |
ATC code |
M01AE04 |
PubChem |
CID 3342 |
DrugBank |
DB00573 |
ChemSpider |
3225 Y |
UNII |
RA33EAC7KY Y |
KEGG |
D02350 Y |
ChEBI |
CHEBI:5004 Y |
ChEMBL |
CHEMBL1297 Y |
Chemical data |
Formula |
C15H14O3 |
Mol. mass |
242.26986 g/mol |
SMILES
- O=C(O)C(c2cc(Oc1ccccc1)ccc2)C
|
InChI
-
InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17) Y
Key:RDJGLLICXDHJDY-UHFFFAOYSA-N Y
|
Y (what is this?) (verify)
|
Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.
Contents
- 1 Pharmacology
- 2 Contraindications
- 3 Drug interactions
- 4 Laboratory test interactions
- 5 Brand names
- 6 References
|
Pharmacology
Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.
Contraindications
History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
Drug interactions
- Aminoglycosides (e.g. gentamicin): Plasma aminoglycoside levels may be elevated.
- Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
- Anticoagulants: Coadministration may prolong prothrombin time.
- Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
- Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
- Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
- Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
- Methotrexate: May increase methotrexate levels.
- Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
- SSRIs (e.g. fluoxetine, citalopram): The risk of GI effects may be increased.
Laboratory test interactions
False elevation in free and total serum T 3 as measured by Amerlex-M kit.
Brand names
- UK - Fenopron (Typharm Limited)
References
- Fenoprofen info from Drugs.com
UpToDate Contents
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English Journal
- Potential of synchrotron X-ray powder diffractometry for detection and quantification of small amounts of crystalline drug substances in pharmaceutical tablets.
- Yamada H, Masuda K, Ishige T, Fujii K, Uekusa H, Miura K, Yonemochi E, Terada K.SourceCMC Research Center, Analytical Chemistry Research Department, Mitsubishi Tanabe Pharma Corporation, 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Sep 10;56(2):448-53. Epub 2011 Jun 6.
- The purpose of this study was to develop a sensitive system for detection of crystalline drug substances in intact pharmaceutical tablets by X-ray powder diffractometry (XRPD), using synchrotron X-rays. Fenoprofen calcium dihydrate was used as a model compound. The wavelength and path length of X-ra
- PMID 21703798
- A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration.
- Wang Z, Liu C, Kang J.SourceShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling Road 345, Shanghai, China.
- Journal of chromatography. A.J Chromatogr A.2011 Apr 1;1218(13):1775-9. Epub 2011 Feb 4.
- A highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed. Several CE techniques, such as the partial filling, large-volume sample stacking with EOF as pump plus anion-selectiv
- PMID 21342694
Related Links
- Learn about the prescription medication Nalfon (Fenoprofen Calcium), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
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★リンクテーブル★
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- 英
- fenoprofen、fenoprofen calcium
- 関
- フェノプロフェンカルシウム
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- 英
- fenoprofen calcium
- 関
- フェノプロフェン
[★]
フェノプロフェン
- 関
- fenoprofen calcium
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