WordNet

a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
a nonsteroidal anti-inflammatory drug (trade name Nalfon) used in the treatment of arthritis and other painful inflammatory disorders (同)fenoprofen_calcium, Nalfon

PrepTutorEJDIC

『カルシウム』(金属元素;化学記号は『Ca』)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/02 19:00:34」(JST)

wiki en

[Wiki en表示]

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug interactions

Aminoglycosides (e.g. gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong prothrombin time.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (e.g. fluoxetine, citalopram): The risk of GI effects may be increased.

Laboratory test interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names

UK - Fenopron (Typharm Limited)

References

Fenoprofen info from Drugs.com

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 成人における片頭痛の予防的治療 preventive treatment of migraine in adults
2. 急性間質性腎炎の臨床症状および診断 clinical manifestations and diagnosis of acute interstitial nephritis
3. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の一次予防 nsaids including aspirin primary prevention of gastroduodenal toxicity
4. 思春期におけるカルシウムの所要量 calcium requirements in adolescents
5. Calcium: Drug formulations (oral and parenteral)

English Journal

Potential of synchrotron X-ray powder diffractometry for detection and quantification of small amounts of crystalline drug substances in pharmaceutical tablets.

Yamada H, Masuda K, Ishige T, Fujii K, Uekusa H, Miura K, Yonemochi E, Terada K.SourceCMC Research Center, Analytical Chemistry Research Department, Mitsubishi Tanabe Pharma Corporation, 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Sep 10;56(2):448-53. Epub 2011 Jun 6.
The purpose of this study was to develop a sensitive system for detection of crystalline drug substances in intact pharmaceutical tablets by X-ray powder diffractometry (XRPD), using synchrotron X-rays. Fenoprofen calcium dihydrate was used as a model compound. The wavelength and path length of X-ra
PMID 21703798

A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration.

Wang Z, Liu C, Kang J.SourceShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling Road 345, Shanghai, China.
Journal of chromatography. A.J Chromatogr A.2011 Apr 1;1218(13):1775-9. Epub 2011 Feb 4.
A highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed. Several CE techniques, such as the partial filling, large-volume sample stacking with EOF as pump plus anion-selectiv
PMID 21342694

「フェノプロフェン」

Fenoprofen
Systematic (IUPAC) name
	2-(3-phenoxyphenyl)propanoic acid
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a681026
Pregnancy cat.	D (US) C
Legal status	POM (UK) ℞-only (US)
Routes	Oral
Pharmacokinetic data
Metabolism	Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Half-life	3 hours
Excretion	Renal (~90%)
Identifiers
CAS number	29679-58-1
ATC code	M01AE04
PubChem	CID 3342
DrugBank	DB00573
ChemSpider	3225
UNII	RA33EAC7KY
KEGG	D02350
ChEBI	CHEBI:5004
ChEMBL	CHEMBL1297
Chemical data
Formula	C15H14O3
Mol. mass	242.26986 g/mol
	SMILES O=C(O)C(c2cc(Oc1ccccc1)ccc2)C;
	InChI InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17) ; Key:RDJGLLICXDHJDY-UHFFFAOYSA-N ;
(what is this?) (verify);