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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/12 14:04:19」(JST)

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English Journal

  • Involvement of glutamate, oxidative stress and inducible nitric oxide synthase in the convulsant activity of ciprofloxacin in mice.
  • Abdel-Zaher AO, Afify AH, Kamel SM, Farghaly HM, El-Osely GM, El-Awaad EA.SourceDepartment of Pharmacology, Faculty of Medicine, Assiut University, Egypt. ahmedosmanaz@hotmail.com
  • European journal of pharmacology.Eur J Pharmacol.2012 Jun 15;685(1-3):30-7. Epub 2012 Apr 20.
  • This study investigated the potential convulsive activity of ciprofloxacin in mice and the possible mechanism(s) of this activity. Intraperitoneal (i.p.) administration of ciprofloxacin into mice resulted in convulsive seizures in a dose-dependent manner. The clonic median convulsant dose (CD(50)) o
  • PMID 22542655
  • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.
  • Jaturapatporn D, Isaac MG, McCleery J, Tabet N.SourceDepartment of Family Medicine, Ramathibodi Hospital, Mahidol University, Bangkok and Baycrest Centre for Geriatric Care,University of Toronto, Toronto, Canada. drdarinj@yahoo.com.
  • Cochrane database of systematic reviews (Online).Cochrane Database Syst Rev.2012 Feb 15;2:CD006378.
  • BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia. The incidence of AD rises exponentially with age and its prevalence will increase significantly worldwide in the next few decades. Inflammatory processes have been suspected in the pathogenesis of the disease.OBJECTIVES: To re
  • PMID 22336816

Japanese Journal

  • Combining a Solution-Phase Derived Library with In-Situ Cellular Bioassay: Prompt Screening of Amide-Forming Minilibraries Using MTT Assay
  • Chiang Li-Wu,Pei Kai,Chen Shao-Wei,Huang Ho-Lien,Lin Kun-Ju,Yen Tzu-Chen,Yu Chung-Shan
  • … 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay of the crude mixtures showed that analogues derived from fenbufen, butylfenbufen C15; …
  • NAID 130000124372
  • Antioxidant Activity and Inhibition of Human Neutrophil Oxidative Burst Mediated by Arylpropionic Acid Non-steroidal Anti-inflammatory Drugs(Medicinal Chemistry)
  • COSTA David,MOUTINHO Luis,LIMA Jose Luis Fontes Costa,FERNANDES Eduarda
  • Biological & pharmaceutical bulletin 29(8), 1659-1670, 2006-08-01
  • … Therefore, the aim of the present work was to evaluate and compare the potential scavenging activity for an array of ROS (O^<・->_2, H_2O_2, HO^・, ROO^・ and HOCl) and RNS (^・NO and ONOO^-) using in vitro non-cellular screening systems as well as a cellular screening system (human neutrophil oxidative burst), mediated by the arylpropionic acid derivatives (APAs) NSAIDs ibuprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, naproxen and indoprofen. …
  • NAID 110005664008

Related Links

フェンブフェン fenbufen 「概念」 ビフェニル酢酸のプロドラッグのこと。 「薬理」 体内でビフェニル酢酸に代謝される。 「作用」 抗炎症作用(インドメタシンより弱い) 「副作用」 稀に、過敏症、ショックなど。
1. Drugs. 1981 Jan;21(1):1-22. Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Brogden RN, Heel RC, Speight TM, Avery GS. Fenbufen is a phenylalkanoic acid derivative ...

Related Pictures

Fenbufen.svgWeb information on FenbufenFenbufen by Damien HirstDescription Fenbufen synthesis.svgFenbufen-from-xtal-1988-3D-balls.pngDescription Fenbufen-2D-skeletal.png





  • プロピオン酸系非ステロイド性抗炎症薬;プロドラッグ