felypressin

フェリプレシン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/17 23:01:50」(JST)

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Felypressin
IUPAC name 1-[19-Amino-13,16-dibenzyl-10-(2-carbamoyl-ethyl)-7-carbamoylmethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloeicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid [5-amino-1-(carbamoylmethyl-carbamoyl)-pentyl]-amide
Identifiers
CAS number	56-59-7 Y
PubChem	5956
ChemSpider	16736539 Y
UNII	17N2918V6G Y
DrugBank	DB00093
ChEBI	CHEBI:60564 Y
ChEMBL	CHEMBL1697764 N
Jmol-3D images	Image 1
SMILES NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H]4NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CSSC4)CC(N)=O
InChI InChI=1S/C46H65N13O11S2/c47-18-8-7-14-29(40(64)52-23-38(51)62)54-45(69)35-15-9-19-59(35)46(70)34-25-72-71-24-28(48)39(63)55-31(20-26-10-3-1-4-11-26)43(67)56-32(21-27-12-5-2-6-13-27)42(66)53-30(16-17-36(49)60)41(65)57-33(22-37(50)61)44(68)58-34/h1-6,10-13,28-35H,7-9,14-25,47-48H2,(H2,49,60)(H2,50,61)(H2,51,62)(H,52,64)(H,53,66)(H,54,69)(H,55,63)(H,56,67)(H,57,65)(H,58,68)/t28-,29-,30-,31-,32-,33-,34-,35-/m0/s1 Y Key: SFKQVVDKFKYTNA-DZCXQCEKSA-N Y InChI=1/C46H65N13O11S2/c47-18-8-7-14-29(40(64)52-23-38(51)62)54-45(69)35-15-9-19-59(35)46(70)34-25-72-71-24-28(48)39(63)55-31(20-26-10-3-1-4-11-26)43(67)56-32(21-27-12-5-2-6-13-27)42(66)53-30(16-17-36(49)60)41(65)57-33(22-37(50)61)44(68)58-34/h1-6,10-13,28-35H,7-9,14-25,47-48H2,(H2,49,60)(H2,50,61)(H2,51,62)(H,52,64)(H,53,66)(H,54,69)(H,55,63)(H,56,67)(H,57,65)(H,58,68)/t28-,29-,30-,31-,32-,33-,34-,35-/m0/s1 Key: SFKQVVDKFKYTNA-DZCXQCEKBI
Properties
Molecular formula	C46H65N13O11S2
Molar mass	1040.22 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N (verify) (what is: Y/N?)
Infobox references

Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. It is added to some local anaesthetics such as prilocaine in a concentration of 0.03 IU/ml. Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As. It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered.

V1 receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).

Another example of a V1 agonist is terlipressin - which is used in oesophageal varices.

References

• "Vasopressin analogues and treatments", Prof Buckingham, Imperial College School of Medicine (ICSM) - adapted by JHPatel

English Journal

• Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol.

• Fleury CA1, Andreo VC, Lomba PC, Dionísio TJ, Amaral SL, Santos CF, Faria FA.
• Journal of anesthesia.J Anesth.2014 Jun 25. [Epub ahead of print]
• PURPOSE: Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin's effects. The present study aimed to analyze and compare the effects of these two vasoconstrictors, injected by the intravenous route, on the arterial pressure of normo
• PMID 24962945

• Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars.

• Arteagoitia I1, Zumarraga M, Dávila R, Barbier L, Santamaría G, Santamaria J.
• Medicina oral, patología oral y cirugía bucal.Med Oral Patol Oral Cir Bucal.2014 May 1;19(3):e274-9.
• OBJECTIVES: Was to evaluate the effect of different regional anesthetics (articaine with epinephrine versus prilocaine with felypressin) on stress in the extraction of impacted lower third molars in healthy subjects.STUDY DESING: A prospective single-blind, split-mouth cross-over randomized study wa
• PMID 24316704

• Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment.

• Gajjar K1, Martin-Hirsch PP, Bryant A.
• The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2012 Oct 17;10:CD006120. doi: 10.1002/14651858.CD006120.pub3.
• BACKGROUND: Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the NHS cervical screening guidelines suggest that over 80% of treatments should be performed in an outpatient setting (colposcopy clinics). F
• PMID 23076919

Japanese Journal

• Felypressin, but not epinephrine, reduces myocardial oxygen tension after an injection of dental local anesthetic solution at routine doses

• Inagawa M,Ichinohe T,Kaneko Y
• Journal of oral and maxillofacial surgery 68(5), 1013-1017, 2010-05
• NAID 120002273759

• アドレナリン添加リドカインとフェリプレシン添加プロピトカインの使い分けは?

• 一戸 達也
• 齒科學報 109(4), 403-404, 2009-08-30
• NAID 10025673366

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