WordNet
- resistant to destruction or fading; "fast colors"
- abstaining from food (同)fasting
- securely fixed in place; "the post was still firm after being hit by the car" (同)firm, immobile
- firmly or closely; "held fast to the rope"; "her foot was stuck fast"; "held tight" (同)tight
- (of a photographic lens or emulsion) causing a shortening of exposure time; "a fast lens"
- (of surfaces) conducive to rapid speeds; "a fast road"; "grass courts are faster than clay"
- (used of timepieces) indicating a time ahead of or later than the correct time; "my watch is fast"
- abstain from certain foods, as for religious or medical reasons; "Catholics sometimes fast during Lent"
- abstain from eating; "Before the medical exam, you must fast"
- acting or moving or capable of acting or moving quickly; "fast film"; "on the fast track in school"; "set a fast pace"; "a fast car"
- at a rapid tempo; "the band played a fast fox trot"
- quickly or rapidly (often used as a combining form); "how fast can he get here?"; "ran as fast as he could"; "needs medical help fast"; "fast-running rivers"; "fast-breaking news"; "fast-opening (or fast-closing) shutters"
- 100 at equal 1 kip in Laos
- (nontechnical usage) a tiny piece of anything (同)molecule, particle, corpuscle, mote, speck
- (physics and chemistry) the smallest component of an element having the chemical properties of the element
- the condition of being dissociated into ions (as by heat or radiation or chemical reaction or electrical discharge); "the ionization of a gas" (同)ionisation
- the process of ionizing; the formation of ions by separating atoms or molecules or radicals or by adding or subtracting electrons from atoms by strong electric fields in a gas (同)ionisation
- the act (or an instance) of subjecting a body or substance to the impact of high-energy particles (as electrons or alpha rays)
PrepTutorEJDIC
- 『速い』,急速な,すばやい,敏速な / (時計が)『進んでいる』 / 『しっかりした』,ぐらつかない / 心の変わらない,忠実な(faithful) / (色が)あせない / 《古》(女性が)身持ちの悪い;《まれに》(生活が)享楽的な / (フイルムが)高感度の,(レンズが)高速撮影用の / 『速く』;すばやく(quickly) / 『しっかりと』,固く(firmly) / 『ぐっすりと』(soundly) / どしどし,ひっきりなしに
- 断食(だんじき),絶食 / (宗教的行事としての)断食日,断食期間 / 断食する,絶食する / (…で)精進する《+『on』+『名』》
- 《場所・位置のある一点》『…で』,『…に』 / 《時間・年齢・目盛りなどの一点》『…に』,『…で』 / 『…の最中で』,に出席して / 『…の状態に』(『で』) / 『…を目指して』,に向かって / 《移動の経路》…を通って,…から / 《動作・感情などの原因・理由・動機》『…によって』,…を見て(聞いて,知って) / 《運動・動作の方法・様態》…で,…のやり方で / 《数量・割合・率》…で,…に / 《能力・性質などの存在場所》…が,…の点で
- 『原子』 / 微量,非常な少量;《a~》微量,わずか(の…)《+『of』+『名』》
- 砲撃,爆撃
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/18 20:52:22」(JST)
[Wiki en表示]
ThermoQuest AvantGarde MS with quadrupole detector and FAB/EI source.
Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions.[1][2][3][4] When a beam of high energy ions is used instead of atoms, the method is known as liquid secondary ion mass spectrometry.[5][6] The material to be analyzed is mixed with a non-volatile chemical protection environment called a matrix and is bombarded under vacuum with a high energy (4000 to 10,000 electron volts) beam of atoms. The atoms are typically from an inert gas such as argon or xenon. Common matrices include glycerol, thioglycerol, 3-nitrobenzyl alcohol (3-NBA), 18-crown-6 ether, 2-nitrophenyloctyl ether, sulfolane, diethanolamine, and triethanolamine. This technique is similar to secondary ion mass spectrometry and plasma desorption mass spectrometry.
Contents
- 1 How it works
- 2 Applications
- 3 References
- 4 Bibliography
How it works
FAB is a relatively low fragmentation (soft) ionization technique and produces primarily intact protonated molecules denoted as [M + H]+ and deprotonated molecules such as [M - H]-. The nature of its ionization mechanism is similar to electrospray ionization and matrix-assisted laser desorption/ionization (MALDI).[7]
Applications
The first example of the practical application of this technique was the elucidation of the amino acid sequence of the oligopeptide efrapeptin D. This contained a variety of very unusual amino acid residues.[8] The sequence was shown to be: N-acetyl-L-pip-AIB-L-pip-AIB-AIB-L-leu-beta-ala-gly-AIB-AIB-L-pip-AIB-gly-L-leu-L-iva-AIB-X. PIP = pipecolic acid, AIB = alpha-amino-isobutyric acid, leu = leucine, iva = isovaline, gly = glycine. This is a potent inhibitor of the mitochodrial ATPase activity.
References
- ^ Morris HR, Panico M, Barber M, Bordoli RS, Sedgwick RD, Tyler A (1981). "Fast atom bombardment: a new mass spectrometric method for peptide sequence analysis". Biochem. Biophys. Res. Commun. 101 (2): 623–31. doi:10.1016/0006-291X(81)91304-8. PMID 7306100. edit
- ^ Barber, M.; Bordoli, R.S.; Sedgewick, R.D.; Tyler, A.N., Nature, 293, 1981, pp270-275
- ^ Barber, Michael; Bordoli, Robert S.; Elliott, Gerard J.; Sedgwick, R. Donald; Tyler, Andrew N. (1982). "Fast Atom Bombardment Mass Spectrometry". Analytical Chemistry 54 (4): 645A–657A. doi:10.1021/ac00241a817. ISSN 0003-2700. edit
- ^ Barber M, Bordoli RS, Sedgewick RD Tyler AN (1981). "Fast atom bombardment of solids (F.A.B.): a new ion source for mass spectrometry". Journal of the Chemical Society, Chemical Communications (7): 325–7. doi:10.1039/C39810000325. edit
- ^ Dominic M. Desiderio (14 November 1990). Mass Spectrometry of Peptides. CRC Press. pp. 174–. ISBN 978-0-8493-6293-4.
- ^ De Pauw, E.; Agnello, A.; Derwa, F. (1991). "Liquid matrices for liquid secondary ion mass spectrometry-fast atom bombardment: An update". Mass Spectrometry Reviews 10 (4): 283–301. doi:10.1002/mas.1280100402. ISSN 0277-7037. edit
- ^ Tomer KB (1989). "The development of fast atom bombardment combined with tandem mass spectrometry for the determination of biomolecules". Mass Spectrometry Reviews 8 (6): 445–82. doi:10.1002/mas.1280080602. edit
- ^ Bullough,D.A., Jackson C.G.,Henderson, P.J.F., Cottee, F.H.,Beechey,R.B. and Linnett, P.E. Biochemistry International (1981) 4, 543-549
Bibliography
- Caprioli, R. M. (1990). Continuous-flow fast atom bombardment mass spectrometry. New York: Wiley. ISBN 0-471-92863-1.
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Mass spectrometry
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|
- Mass
- m/z
- Mass spectrum
- MS software
- Acronyms
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| Ion source |
- APCI
- APLI
- CI
- DAPPI
- DART
- DESI
- DIOS
- EESI
- EI
- ESI
- FAB
- FD
- GD
- IA
- ICP
- LAESI
- MALDI
- MIP
- SS
- SSI
- TI
- TS
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| Mass analyzer |
- Sector
- Wien filter
- Time-of-flight
- Quadrupole mass filter
- Quadrupole ion trap
- FT-ICR
- Orbitrap
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| Detector |
- Electron multiplier
- Microchannel plate detector
- Daly detector
- Faraday cup
- Langmuir–Taylor detector
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| MS combination |
- MS/MS
- QqQ
- Hybrid MS
- GC/MS
- LC/MS
- IMS/MS
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| Fragmentation |
- BIRD
- CID
- ECD
- EDD
- ETD
- HCD
- IRMPD
- NETD
- SID
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Deiodination of iodinated aromatic compounds with electrospray ionization mass spectrometry.
- Hvattum E1, Priebe H.
- Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2013 Nov 15;27(21):2504-14. doi: 10.1002/rcm.6711.
- RATIONALE: Dehalogenation of iodinated X-ray contrast media (ICM) has been reported using electrochemical and bioelectrochemical systems. Correspondingly, dehalogenation of aromatic halogens has also been reported in mass spectrometry (MS) using different ionization techniques like chemical ionizati
- PMID 24097407
- A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization.
- Xie C1, Zhong D, Chen X.
- Analytica chimica acta.Anal Chim Acta.2013 Jul 25;788:89-98. doi: 10.1016/j.aca.2013.06.022. Epub 2013 Jun 20.
- Idiosyncratic reactions are one of the major causes of drug treatment limitations or market withdrawals, and likely involve the formation of reactive metabolites. Because of their unstable nature, reactive species are usually discovered as stable conjugates by glutathione (GSH) trapping rather than
- PMID 23845486
- Thioglycerol matrix interactions in the positive ion fast atom bombardment mass spectrometry of several Hantzsch and Biginelli ester derivatives of boronic acids.
- Martínez J1, Abarca V, Pérez FJ, Carranza V, Miranda R.
- Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2013 Jul 15;27(13):1573-8. doi: 10.1002/rcm.6604.
- RATIONALE: Fast atom bombardment (FAB) ionization is a valuable tool for analyzing non-volatile or thermally labile compounds when harder ionization methods (EI or CI) have been unsuccessful. Unexpected interactions between matrix and analyte may, however, occur in FAB ionization leading to the form
- PMID 23722692
Japanese Journal
- LSI/FABを用いる多官能性ヌクレオシドホスホロアミダイトのマススペクトル測定
- 藤嶽 美穂代,春沢 信哉
- 薬学雑誌. 乙号 133(7), 823-841, 2013
- … Accurate molecular weight measurements of such acid-labile compounds may be easily determined in a matrix system comprising triethanolamine (TEOA)-NaCl by liquid secondary ionization mass spectrometry (LSIMS) or fast atom bombardment mass spectrometry (FABMS), using a double-focusing mass spectrometer. …
- NAID 130003361966
- エレクトロスプレー帯電水滴衝撃による脱離イオン化メカニズム
- 浅川 大樹,平岡 賢三
- 質量分析 = Mass spectroscopy 59(5), 95-105, 2011-10-01
- … Electrospray droplet impact (EDI) secondary ion mass spectrometry (SIMS) is a desorption/ionization technique for mass spectrometry. … Two mechanisms for desorption/ionization in the EDI ionization process have been proposed, namely, low-energy and high-energy regimes. …
- NAID 10029699748
- Identification of the Catalytic Residues of Carboxylesterase from Arthrobacter globiformis by Diisopropyl Fluorophosphate-Labeling and Site-Directed Mutagenesis
- Nishizawa Masako,Yabusaki Yoshiyasu,Kanaoka Masaharu
- Bioscience, biotechnology, and biochemistry 75(1), 89-94, 2011-01-23
- … The electrospray ionization mass spectrometric (ESI-MS) analysis of the esterase, covalently labeled by DFP, showed stoichiometric incorporation of the inhibitor into the enzyme. …
- NAID 10027896792
Related Links
- IUPAC RECOMMENDATIONS 2013 K. K. Murray, R. K. Boyd, M. N. Eberlin, G. J. Langley, L. Li and Y. Naito, Pure Appl. Chem., 2013, 85, 1515-1609, 10.1351/PAC-REC-06-04-06. Fast atom bombardment ionization (FAB) ...
- Fast atom bombardment is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions. It was developed by Michael Barber at the University of Manchester. When a beam ...
★リンクテーブル★
[★]
- 英
- fast atom bombardment ionization
[★]
-
- 早い、急速な(opp. slow)
- すばやい、敏捷な。手の早い
- 短期間の
- 時間のかからない、手間の要らない
- (時間が)早い、進んでいる。(はかりが)実際より大きな値を示す。夏時間の
- 高速用の、敏速な動きに適した
- 固着した、しっかりした、ぐらつかない(opp. loose)
- 固く締まった。しっかりした(縫い目・握り方など)
- 心の変わらぬ(constant)、忠実な
- (色が)あせない、色あせしない、堅牢な。耐…性の。(菌)(破壊または染色に対して)耐性のある
- acid-fast bacteria 抗酸菌
- 関
- fasted、fasting、food deprivation、high speed、high-performance、high-speed、highperformance、quick、rapid、swift
[★]
- 関
- illuminate、irradiate、irradiation、radiate、radiation
[★]
- 関
- fast、fasting、food deprivation
[★]
Focused Assessment with Sonography for Trauma
[★]
- 関
- atomic