English Journal

Genetic response to farnesyltransferase inhibitors: proapoptotic targets of RhoB.

Kamasani U1, Liu AX, Prendergast GC.
Cancer biology & therapy.Cancer Biol Ther.2003 May-Jun;2(3):273-80.
Knockout mouse studies have established that the transformation-selective death program triggered by farnesyltransferase inhibitor (FTI) requires a gain-of-function in the stress-regulated small GTPase RhoB. To gain insight into this death program, we compared the genetic response of cells with diff
PMID 12878865

Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery.

Kato N1, Nemoto K, Arino H, Fujikawa K.
Journal of the neurological sciences.J Neurol Sci.2002 Oct 15;202(1-2):69-74.
An experimental study was performed to investigate the influence of subsidence of chronic inflammation in peripheral target tissue on the recovery of crushed nerve. Seventy-eight male Wistar rats weighing 300-370 g were used. The sciatic nerve was operatively crushed unilaterally with an aneurysm cl
PMID 12220695

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant.

Yang W1, Tabancay AP Jr, Urano J, Tamanoi F.
Molecular microbiology.Mol Microbiol.2001 Sep;41(6):1339-47.
Protein farnesylation is important for a number of physiological processes, including proliferation and cell morphology. The Schizosaccharomyces pombe mutant, cpp1-, defective in farnesylation, exhibits distinct phenotypes, including morphological changes and sensitivity to the arginine analogue, ca
PMID 11580838

Japanese Journal

内山秀盛,田中達徳,上原信行,中村優,辻正義,四宮充普,田中英嗣
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 17(Supplement III), 283-312, 1992-11-30
PNFゲルの安全性評価の一環としてウサギを用いて皮膚一次刺激性試験, 皮膚累積刺激性試験(Trypan blue test)および眼粘膜一次刺激性試験, モルモットを用いて光毒性試験, 皮膚感作性試験および光感作性試験を行い, 以下のような結果を得た。1. 皮膚一次刺激性試験および皮膚累積刺激性試験(Trypan blue test)では,0.8および1.6% PNFゲルに弱い刺激性が認められた。 …
NAID 110001805173

大塚雅則,安心院祥三,梶原美次,小椋正造,柿本敬次郎,稲井恒彦,田中英嗣,大内田昭信
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 17(Supplement III), 269-281, 1992-11-30
… Prednisolone farnesylate (PNF) was tested for mutagenicity by Ames test using Salmonella typhimurium (TAl00, TA1535, TA98, TA1537) and Escherichia coli (WP2 uvrA), for clastogenic activity in vitro by the chromosomal aberration test in a Chinese hamster fibroblast cell line (CHL), and for induction of micronuclei by the micronucleus test in male ICR mice. …
NAID 110001805172

谷口英巳,荒木栄喜,永井元弘,真崎克典,溝口重光,中村優,辻正義,田中英嗣,四宮充普
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 17(Supplement III), 251-267, 1992-11-30
PNFの0.05, 0.5および5 mg/kgをCrj: CD (SD)系ラットの周産期および授乳期に皮下投与し, 母獣ならびに出生児の成長・発達および生殖能力に及ぼす影響について検討し, 以下の結果を得た。1. 母獣(F_0)では, 0.5mg/kg以上の投与群で体重増加の抑制, 胸腺の萎縮, PNFの投与部への貯留を示唆する所見が認められた。しかし, いずれの投与群とも一般状態および摂餌量に異 …
NAID 110001805171