プロペルジン
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the 16th letter of the Roman alphabet (同)p
- a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- parking
- phosphorusの化学記号
- palladiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/16 17:42:48」(JST)
[Wiki en表示]
CFP |
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Available structures |
PDB |
Ortholog search: PDBe RCSB |
List of PDB id codes |
1W0R, 1W0S
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Identifiers |
Aliases |
CFP, BFD, PFC, PFD, PROPERDIN, complement factor properdin, Properdin |
External IDs |
MGI: 97545 HomoloGene: 1969 GeneCards: CFP |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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NP_001138724.1
NP_002612.1
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Location (UCSC) |
Chr X: 47.62 – 47.63 Mb |
Chr X: 20.93 – 20.93 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
Properdin or Factor P is the only known positive regulator of complement activation that stabilizes the alternative pathway convertases. It is found in the blood serum of more complex animals.
Contents
- 1 Structure
- 2 Function
- 3 History
- 4 Deficiency
- 5 External links
Structure
Properdin is a gamma globulin protein composed of multiple identical protein subunits with a separate ligand-binding site. Native properdin occurs in head-to-tail dimers, trimers and tetramers in the fixed ratio 22:52:28.[3]
Function
It is known that it participates in some specific immune responses. It plays a part in tissue inflammation as well as the engulfing of pathogens by phagocytes. In addition it is known to help to neutralize some viruses.
The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface. It binds to preformed alternative pathway C3-convertases.[4] Properdin also inhibits the Factor H – mediated cleavage of C3b by Factor I.
Alternative pathway. Properdin is the "P" in the blue circles. (Some labels are in Polish.)
The alternative pathway is not dependent on antibodies. This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins, polysaccharides, and cell walls, and results in producing anaphylatoxins, opsonins, chemotactic factors, and the membrane attack complex, all of which help fight pathogens.
History
Properdin was discovered in 1954 by Dr. Louis Pillemer of the Institute of Pathology (now the Department of Pathology at Case Western Reserve University).
Deficiency
Properdin deficiency is a rare X-linked disease in which properdin is deficient. Affected individuals are susceptible to fulminant meningococcal disease.[5]
External links
- Properdin at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Smith C, Pangburn M, Vogel CW, Müller-Eberhard H (1984). "Molecular Architecture of Human Properdin, a Positive Regulator of the Alternative Pathway of Complement". J Biol Chem. 259: R4582–4588.
- ^ Hourcade D (2006). "The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement". J Biol Chem. 281: R2128–2132. doi:10.1074/jbc.m508928200.
- ^ Dr. Lars Otto Uttenthal Properdin September 01 2005
Proteins: Globular proteins
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Serum globulins |
Alpha globulins
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serpins:
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- alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin)
- alpha-2 (Alpha 2-antiplasmin)
- Antithrombin (Heparin cofactor II)
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carrier proteins:
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- alpha-1 (Transcortin)
- alpha-2 (Ceruloplasmin)
- Retinol binding protein
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other:
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- alpha-1 (Orosomucoid)
- alpha-2 (alpha-2-Macroglobulin, Haptoglobin)
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Beta globulins
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carrier proteins:
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- Sex hormone-binding globulin
- Transferrin
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other:
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- Angiostatin
- Hemopexin
- Beta-2 microglobulin
- Factor H
- Plasminogen
- Properdin
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Gamma globulin
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Other
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- Fibronectin (fFN: Fetal fibronectin)
- Macroglobulin/Microglobulin
- Transcobalamin
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Other globulins |
- Beta-lactoglobulin
- Thyroglobulin
- Alpha-lactalbumin
- 11S globulin family (seeds)
- 7S globulin family (seeds)
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Albumins |
Egg white
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- Conalbumin
- Ovalbumin
- Avidin
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Serum albumin
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- Human serum albumin
- Bovine serum albumin
- Prealbumin
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Other
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- C-reactive protein
- Lactalbumin (Alpha-lactalbumin)
- Parvalbumin
- Ricin
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- see also disorders of globin and globulin proteins
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Proteins: complement system (C, L, A)
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Activators/enzymes |
Early |
- A: Factor B
- Factor D
- Factor P/Properdin
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Middle |
- C3-convertase
- C5-convertase
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Late |
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Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
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Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Awareness of osteoporosis, risk and protective factors and own diagnostic status: a cross-sectional study.
- Ní Chróinín D, Glavin P, Power D.SourceDepartment of Geriatric Medicine, Beaumont Hospital, Beaumont, Dublin 11, Ireland, dmmnic@umail.ucc.ie.
- Archives of osteoporosis.Arch Osteoporos.2013 Dec;8(1-2):117. doi: 10.1007/s11657-012-0117-9. Epub 2013 Jan 8.
- We conducted a cross-sectional study of the understanding on osteoporosis amongst community-dwelling geriatric patients. Patient understanding on the pathology, risk factors and its complications was suboptimal, but better amongst women and persons with diagnosed osteoporosis. Improving patient oste
- PMID 23297105
- Monitoring and modeling treatment of atypical hemolytic uremic syndrome.
- Heinen S, Pluthero FG, van Eimeren VF, Quaggin SE, Licht C.SourceSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
- Molecular immunology.Mol Immunol.2013 May;54(1):84-8. doi: 10.1016/j.molimm.2012.10.044. Epub 2012 Dec 3.
- Atypical hemolytic uremic syndrome (aHUS), is mainly present in children, who have high risks of end-stage kidney disease (ESKD), post-transplant recurrence and death. aHUS is linked to defective regulation of the complement alternative pathway (AP), with a prominent cause being mutation/inhibition
- PMID 23220071
- Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages.
- Lee M, Guo JP, McGeer EG, McGeer PL.SourceKinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada.
- Neurobiology of aging.Neurobiol Aging.2013 May;34(5):1451-61. doi: 10.1016/j.neurobiolaging.2012.10.023. Epub 2012 Nov 20.
- Aberrant complement activation is known to exacerbate the pathology in a spectrum of degenerative diseases of aging. We previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent which prevents formation of the membrane attack complex of complement. It inhibits C9 attachmen
- PMID 23177218
Japanese Journal
- 耐震診断による上部構造評点を用いた木造在来軸組構法住宅の地震特性能評価
- Nanomaterials for Environmental Solar Energy Technologies: Applications & Limitations
- 対人過敏・自己優先尺度の作成――「新型うつ」の心理学的特徴の測定――
Related Pictures
★リンクテーブル★
[★]
- 英
- properdin
- 同
- プロパジン、プロペルジン
- factor P
- 関
- 補体、complement-regulatory protein
[show details]
[★]
IMM.64
[★]
転写因子Pit-1
- 関
- Pit-1
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
[★]
- 10の-12乗
- 関
- pico
[★]
パラジウム palladium