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English Journal

Generation of Xenotransplants from Human Cancer Biopsies to Assess Anti-cancer Activities of HDACi.

Mullins CS1, Bock S1, Krohn M1, Linnebacher M2.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1510:217-229.
Human tumor in vivo cancer models raised in immunodeficient mice, the so-called patient-derived xenografts, are increasingly in use in preclinical development and evaluation of novel drug candidates including HDAC inhibitors. Here, we describe the techniques needed to generate novel patient-derived
PMID 27761824

Experiences With Aggressive Cardiac Rehabilitation in Pediatric Patients Receiving Mechanical Circulatory Supports.

Amao R1, Imamura T, Sawada Y, Endo S, Ozaki S, Okamura K, Masuzawa A, Takaoka T, Hirata Y, Shindo T, Ono M, Haga N.
International heart journal.Int Heart J.2016 Dec 2;57(6):769-772. Epub 2016 Nov 9.
Although some patients with fulminant myocarditis can be rescued owing to the improvements in mechanical circulatory support therapy, there are few reports providing evidence of cardiac rehabilitation during mechanical circulatory supports, particularly among pediatric patients. We treated two pedia
PMID 27829640

Single-Center Experience With HeartMate II Left Ventricular Assist Device Explantation.

Tchantchaleishvili V1, Cheyne C1, Sherazi S2, Melvin AL1, Hallinan W1, Chen L3, Todd Massey H1.
Artificial organs.Artif Organs.2016 Dec;40(12):1145-1149. doi: 10.1111/aor.12688. Epub 2016 Apr 14.
In patients with continuous flow left ventricular assist devices (CF-LVADs) myocardial recovery is uncommon. Given the heterogeneity of the population implanted and low incidence of recovery, the discovery of native left ventricular (LV) recovery and criteria for explantation of CF-LVAD system is no
PMID 27076358

A Classical But Useful Predictor of Future Left Ventricular Assist Device Explantation:– Possible Significant Role of Cardiopulmonary Exercise Testing –

Novel Scoring System Using Postoperative Cardiopulmonary Exercise Testing Predicts Future Explantation of Left Ventricular Assist Device

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Circulation Journal 79(3), 560-566, 2015
… Background:Although cardiopulmonary exercise (CPX) testing is an established tool for predicting survival in patients with heart failure (HF), its prognostic impact on explantation of left ventricular assist device (LVAD) was unknown.Methods and Results:We enrolled 33 patients who had undergone implantation of extracorporeal pulsatile flow LVAD and symptom-limited CPX testing at 3 months after operation, and who were followed between 2005 and 2014. …
NAID 130004927117

A Classical But Useful Predictor of Future Left Ventricular Assist Device Explantation:– Possible Significant Role of Cardiopulmonary Exercise Testing –