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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/01 10:10:34」(JST)

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Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.

Kothapalli R1, Sivaraman Siveen K2, Tan TZ3, Paul Thiery J3,4,5, Kumar AP2,3,6,7, Sethi G2, Swaminathan K8.
Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2016 Jun 29:1-10. [Epub ahead of print]
Considering the pathological significance of MMP-13 in breast and colon cancers, exosite-based inhibition of the C-terminal hemopexin (Hpx) domain could serve as an alternative strategy to develop selective inhibitors for MMP-13.Two of six lead compounds, compound 5 (2,3-dihydro-1,4-benzodioxine-5-c
PMID 27362887

Polyphosphate is a novel cofactor for regulation of complement by the serpin, C1-inhibitor.

Wijeyewickrema LC1, Lameignere E2, Hor L1, Duncan RC1, Shiba T3, Travers RJ4, Kapopara PR2, Lei V2, Smith SA4, Kim H5, Morrissey JH4, Pike RN1, Conway EM6.
Blood.Blood.2016 Jun 23. pii: blood-2016-02-699561. [Epub ahead of print]
The complement system plays a key role in innate immunity, inflammation and coagulation. The system is delicately balanced by negative regulatory mechanisms that modulate the host response to pathogen invasion and injury. The serpin, C1 inhibitor (C1-INH), is the only known plasma inhibitor of C1s,
PMID 27338096

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.

Hill ME1, MacPherson DJ1, Wu P1, Julien O, Wells JA, Hardy JA1.
ACS chemical biology.ACS Chem Biol.2016 Jun 17;11(6):1603-12. doi: 10.1021/acschembio.5b00971. Epub 2016 Mar 31.
The ability to routinely engineer protease specificity can allow us to better understand and modulate their biology for expanded therapeutic and industrial applications. Here, we report a new approach based on a caged green fluorescent protein (CA-GFP) reporter that allows for flow-cytometry-based s
PMID 27032039