WordNet

a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid

English Journal

Lemay JF1, Bachand F1.
RNA biology.RNA Biol.2015 Sep 2;12(9):927-32. doi: 10.1080/15476286.2015.1073433.
Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have
PMID 26273910

Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates.

Wen J1, Ladewig E1, Shenker S2, Mohammed J2, Lai EC1.
PLoS computational biology.PLoS Comput Biol.2015 Sep 1;11(9):e1004441. doi: 10.1371/journal.pcbi.1004441. eCollection 2015.
Mirtrons are microRNA (miRNA) substrates that utilize the splicing machinery to bypass the necessity of Drosha cleavage for their biogenesis. Expanding our recent efforts for mammalian mirtron annotation, we use meta-analysis of aggregate datasets to identify ~500 novel mouse and human introns that
PMID 26325366

DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.

Szczepinska T1, Kalisiak K1, Tomecki R1, Labno A1, Borowski LS1, Kulinski T1, Adamska D1, Kosinska J2, Dziembowski A3.
Genome research.Genome Res.2015 Aug 20. pii: gr.189597.115. [Epub ahead of print]
Human DIS3, the nuclear catalytic subunit of the exosome complex, contains exonucleolytic and endonucleolytic active domains. To identify DIS3 targets genome-wide, we combined comprehensive transcriptomic analyses of engineered HEK293 cells that expressed mutant DIS3, with Photoactivatable Ribonucle
PMID 26294688