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Technetium (^99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used by nuclear medicine physicians for the detection of altered regional cerebral perfusion in stroke^[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections^[2] and inflammatory bowel disease.^[3] Exametazime (the part without technetium) is sometimes referred to by its chemical name of hexamethylpropyleneamine oxime or HMPAO.

Chemistry

Exametazime (hexamethylpropyleneamine oxime, HMPAO)

The drug consists of two of the three stereoisomers of hexametazime (HMPAO), one of which is shown here, the other being its enantiomer.^[4] The third stereoisomer is the meso form. Exametazime acts as a chelating agent for the radioisotope technetium-99m.

References

^ Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.
^ Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.
^ Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.
^ Monography in the European Pharmacopoeia

External links

European Association of Nuclear Medicine: Ceretec
GE Healthcare: Ceretec
Exametazime ligand: CID 9552071 from PubChem

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

English Journal

Incidental bone lesion on (⁹⁹m)Tc-exametazime brain perfusion SPECT.

de Haro Del Moral FJ1, Sánchez Lajusticia A2.
Revista española de medicina nuclear e imagen molecular.Rev Esp Med Nucl Imagen Mol.2015 Jan-Feb;34(1):58-9. doi: 10.1016/j.remn.2014.02.006. Epub 2014 Apr 4.
PMID 24703995

18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias.

O'Brien JT1, Firbank MJ2, Davison C3, Barnett N3, Bamford C4, Donaldson C5, Olsen K3, Herholz K6, Williams D3, Lloyd J7.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.J Nucl Med.2014 Dec;55(12):1959-65. doi: 10.2967/jnumed.114.143347. Epub 2014 Nov 5.
Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken.METHODS: Subjects with Alzheimer disease (AD; n
PMID 25453043

In vitro assessment of cytotoxicity and labeling efficiency of 99mTc-HMPAO with stromal vascular fraction of adipose tissue.

Verma VK1, Beevi SS1, Tabassum A2, Kumaresan K2, Kamaraju RS1, Arbab AS3, Chelluri LK4.
Nuclear medicine and biology.Nucl Med Biol.2014 Oct;41(9):744-8. doi: 10.1016/j.nucmedbio.2014.06.002. Epub 2014 Jun 11.
INTRODUCTION: Noninvasive radionuclide imaging of cells using technetium99m-hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) is a potential diagnostic tool for several applications. Herein we aimed to evaluate the labeling efficiency and cellular toxicity of (99m)Tc-HMPAO with Stromal Vascular Fractio
PMID 25037755

Japanese Journal

Uptake of 99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients : association with mania

Brit J Psychiatry 170, 426-430, 1997
NAID 30041180546

Technetium-99m exametazime brain SPECT and magnetic resonance images in the diagnosis of herpes simplex encephalitis

Clin Nucl Med 19, 66-68, 1994
NAID 30018614780

Short-term effects of electroconvulsive treatment on the uptake of 99mTc-exametazime into brain in major depression shown with single photon emission tomography

J Affect Disord 30, 27-34, 1994
NAID 30002719052

Related Pictures

Technetium Tc 99M Exametazime (Tc-99m Technetium ( 99m Tc) exametazime Technetium (99mTc) exametazime, [99mTc Tc99m complex of exametazime is formed Technetium Tc 99M Exametazime; Tc-99m Exametazime Injection (GE Healthcare, Medi Exametazime (hexamethylpropyleneamine

★リンクテーブル★

リンク元

「エキサメタジム」

Technetium (^99mTc) exametazime
Systematic (IUPAC) name
	[[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc)
Clinical data
Trade names	Ceretec
License data	US FDA: Ceretec;
Pregnancy; category	US: C (Risk not ruled out); ;
Routes of; administration	Intravenous
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	; 100551-63-1 (exametazime)
ATC code	V09AA01 (WHO); V09HA02 (WHO) (labelled leucocytes)
PubChem	CID 9552069
UNII	3B744AG22N
Chemical data
Formula	C13H25N4O3Tc
Molar mass	384.3655 g/mol
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　　[★]

英: exametazime
関: [[]]

http://en.wikipedia.org/wiki/Exametazime
Exametazime, labelled with the radioisotope technetium-99m, is a drug used for the detection of altered regional cerebral perfusion in stroke, and for the labelling of leucocytes to localise intra-abdominal infections and inflammatory bowel disease.

Technetium (99mTc) exametazime has the brand name Ceretec.

[1] Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.

[2] Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.

[3] Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.

[4] Monography in the European Pharmacopoeia

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exametazime