UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Transcriptomic analysis of the white rot fungus Polyporus brumalis provides insight into sesquiterpene biosynthesis.

Lee SY1, Kim M1, Kim SH2, Hong CY2, Ryu SH3, Choi IG4.
Microbiological research.Microbiol Res.2016 Jan;182:141-9. doi: 10.1016/j.micres.2015.10.008. Epub 2015 Oct 30.
Object of this study was to identify genes and enzymes that are involved in sesquiterpene biosynthesis in the wood rotting fungus, Polyporus brumalis. Sesquiterpenes, β-eudesmane and β-eudesmol, were produced by the mycelium of P. brumalis cultured in modified medium. However, theses final product
PMID 26686622

Al-Attas AA1, El-Shaer NS2, Mohamed GA3, Ibrahim SR4, Esmat A5.
Journal of ethnopharmacology.J Ethnopharmacol.2015 Dec 24;176:365-74. doi: 10.1016/j.jep.2015.11.026. Epub 2015 Nov 28.
ETHNOPHARMACOLOGICAL RELEVANCE: Costus speciosus (Koen ex. Retz.) Sm. (crepe ginger, family Costaceae) is an ornamental plant used in traditional medicine for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma, flatulence, constipation, helminthiasis, leprosy, skin diseas
PMID 26593213

Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism.

Xie C1, Sun L2, Meng L3, Wang M3, Xu J3, Bartlam M4, Guo Y5.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Nov 15;25(22):5409-11. doi: 10.1016/j.bmcl.2015.09.013. Epub 2015 Sep 7.
One new xanthanolide, 4-(2-methybutyryl)-4H-tomentosin (1) was isolated from the whole plant of Carpesium macrocephalum together with nine known sesquiterpenes (2-10), including four eudesmane sesquiterpenes (2, 4, 5, and 10), one guaianolide (3), two xanthanolides (6 and 9) and two carabranolides (
PMID 26394911

Telekin induces apoptosis associated with the mitochondria-mediated pathway in human hepatocellular carcinoma cells

Zheng Beibei,Wu Lehao,Ma Lisha,Liu Shanshan,Li Lin,Xie Weidong,Li Xia
Biological and Pharmaceutical Bulletin, 2013
… Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells. …
NAID 130003361483

Santonin-Related Compound 2 Inhibits the Nuclear Translocation of NF-/κB Subunit p65 by Targeting Cysteine 38 in TNF-α-Induced NF-κB Signaling Pathway

Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum

Shin Hyun Jung,Lee So Young,Kim Ju Sun [他],Lee Sanghyun,Choi Ran Joo,Chung Ha Sook,Kim Yeong Shik,Kang Sam Sik
Chemical and Pharmaceutical Bulletin 60(3), 306-314, 2012
… Six new germacranolides, zawadskinolides A—F (1—6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. … Bioassay showed that flavonoids such as apigenin (9), (−)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 μM, respectively. …
NAID 130001852414