English Journal

Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS.

Lizot LLF, da Silva ACC, Bastiani MF, Maurer TF, Hahn RZ, Perassolo MS, Antunes MV, Linden R.
Journal of analytical toxicology. 2019 May;().
The determination of cocaine (COC) and its metabolites ecgonine methyl ester (EME), benzoylecgonine (BZE), norcocaine (NCOC) and cocaethylene (CE) in human plasma is relevant in clinical and forensic toxicology. An efficient extraction and clean-up of plasma specimens for the simultaneous determinat
PMID 31095712

Quantification of cocaine and cocaine metabolites in dried blood spots from a controlled administration study using liquid chromatography-tandem mass spectrometry.

Ambach L, Menzies E, Parkin MC, Kicman A, Archer JRH, Wood DM, Dargan PI, Stove C.
Drug testing and analysis. 2019 May;11(5)709-720.
Cocaine is a common illicit stimulant and is mainly metabolized by hydrolysis to benzoylecgonine (BE) and ecgonine methyl ester (EME), but also to minor metabolites like norcocaine, or hydroxy-BE. When ethanol is present, cocaethylene is formed. Dried blood spot (DBS) sampling is a minimally invasiv
PMID 30379417

Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid chromatography coupled to tandem mass spectrometry.

de Lima Feltraco Lizot L, da Silva ACC, Bastiani MF, Hahn RZ, Bulcão R, Perassolo MS, Antunes MV, Linden R.
Forensic science international. 2019 May;298()408-416.
Cocaine (COC) is one of the most widely abused drugs in the world and its sensitive and its reliable measurement in blood is of great importance in the field of forensic and clinical toxicology. Additionally, the determination of COC metabolites such as benzoylecgonine (BZE), cocaethylene (CE), ecgo
PMID 30954922