ethiodized oil

Lipiodol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
ChEMBL	CHEMBL1201458

ヨード化ケシ油エチルエステル

WordNet

cover with oil, as if by rubbing; "oil the wooden surface"
a slippery or viscous liquid or liquefiable substance not miscible with water
oil paint containing pigment that is used by an artist (同)oil_color, oil colour
treated with oil; "oiled country roads"; "an oiled walnut table"

PrepTutorEJDIC

〈U〉〈C〉『油』;油状物 / =petroleum / 《複数形で》=oil paint / =oil painting / …‘に'油を塗る,油を引く,油を差す
油を差した(しみ込ませた) / 《俗》酒に酔った(drunk)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/25 19:58:52」(JST)

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[Wiki en表示]

Lipiodol (labeled Ethiodol in the USA), also known as ethiodized oil, is a poppyseed oil used by injection as a radio-opaque contrast agent that is used to outline structures in radiological investigations.^[1]^[2] It is used in chemoembolization applications as a contrast agent in follow-up imaging.^[3] Lipiodol is also used in lymphangiography, the imaging of the lymphatic system.^[4] It has an additional use in gastric variceal obliteration as a dilutant that does not affect polymerization of cyanoacrylate.

Recently there has been an increasing interest in the use of Lipiodol as a therapeutic agent in the management of unexplained infertility, using a procedure called Lipiodol flushing. There have been a small number of studies that suggest that flushing the media through the tubes gives a short-term rise in fecundity in patients with unexplained infertility. A systematic review has suggested a significant increase in fertility, especially in those women who have endometriosis when using Lipiodol flushing.^[5]

Historically Lipiodol was often used as a contrast medium at hysterosalpingography (HSG: a procedure to determine tubal patency, used in the investigation of subfertility). It became less commonly utilised in the 1960s to 1980s because the more modern water-soluble media give images that are easier to interpret. There is also an important safety issue with Lipiodol in that intravasation (leakage) of the fluid into the venous system has caused complications in the past.

Ethiodized oil is composed of iodine combined with ethyl esters of fatty acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl diiodostearate. The precise structure is not known. Lipiodol was first synthesized by Marcel Guerbet in the Paris School of Pharmacy in 1901. Historically, Lipiodol was the first iodinated contrast agent (used for myelography by two French physicians, Jacques Forestier and Jean Sicard in 1921).

Lipiodol is now solely produced and marketed by Guerbet since Savage Laboratories discontinued manufacturing in 2010.^[6]

References

^ Ahrar, K.; Gupta, S. (Jan 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes.". Surg Oncol Clin N Am 12 (1): 105–26. doi:10.1016/s1055-3207(02)00089-3. PMID 12735133.
^ Sato, T. (Apr 2002). "Locoregional immuno(bio)therapy for liver metastases.". Semin Oncol 29 (2): 160–7. doi:10.1053/sonc.2002.31716. PMID 11951214.
^ Guan, YS.; Hu, Y.; Liu, Y. (Jun 2006). "Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization.". J Gastroenterol Hepatol 21 (6): 941–6. doi:10.1111/j.1440-1746.2006.04474.x. PMID 16724976.
^ Cabanas, RM. (2000). "The concept of the sentinel lymph node.". Recent Results Cancer Res 157: 109–20. doi:10.1007/978-3-642-57151-0_9. PMID 10857165.
^ Johnson, NP. (2005). "A review of the use of lipiodol flushing for unexplained infertility.". Treat Endocrinol 4 (4): 233–43. doi:10.2165/00024677-200504040-00004. PMID 16053340.
^ http://www.guerbet-us.com/?page=lipiodol

UpToDate Contents

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1. 肝胆道のCT撮影 computed tomography of the hepatobiliary tract
2. 全身治療および非外科的局所治療を受けている肝細胞癌患者における治療効果判定 assessment of tumor response in patients receiving systemic and nonsurgical locoregional treatment of hepatocellular cancer
3. ヨード欠乏症 iodine deficiency disorders
4. 甲状腺髄様癌：治療および予後 medullary thyroid cancer treatment and prognosis
5. 従来の胸部X線によるびまん性肺疾患の評価 evaluation of diffuse lung disease by conventional chest radiography

English Journal

Single-step multimodal locoregional treatment for unresectable hepatocellular carcinoma: balloon-occluded percutaneous radiofrequency thermal ablation (BO-RFA) plus transcatheter arterial chemoembolization (TACE).

Iezzi R, Cesario V, Siciliani L, Campanale M, De Gaetano AM, Siciliano M, Agnes S, Giuliante F, Grieco A, Pompili M, Rapaccini GL, Gasbarrini A, Bonomo L; HepatoCATT Group for the Multidisciplinary Management of HCC.SourceDepartment of Bioimaging and Radiological Sciences, Institute of Radiology, A Gemelli Hospital, Catholic University, L.go A Gemelli 8, 00168 Rome, Italy. roberto.iezzi@rm.unicatt.it
La Radiologia medica.Radiol Med.2013 Jun;118(4):555-69. doi: 10.1007/s11547-012-0914-7. Epub 2013 Jan 28.
PURPOSE: This study was undertaken to evaluate the feasibility, safety and efficacy of a new combined single-step therapy in patients with unresectable multinodular unilobar hepatocellular carcinoma (HCC), with at least one lesion >3 cm, with balloon-occluded radiofrequency ablation (BO-RFA) plus
PMID 23358819

Transarterial chemoembolization of hepatocellular carcinoma. Agents and drugs: an overview. Part 1.

Giunchedi P, Maestri M, Gavini E, Dionigi P, Rassu G.SourceUniversity of Sassari, Department of Chemistry and Pharmacy, Sassari, Italy. pgiunc@uniss.it
Expert opinion on drug delivery.Expert Opin Drug Deliv.2013 May;10(5):679-90. doi: 10.1517/17425247.2013.770733. Epub 2013 Feb 13.
INTRODUCTION: Hepatocellular carcinoma (HCC) is one of the most common lethal malignancies. The prognosis is poor despite progress in early diagnosis. The initial treatment of choice is hepatic resection; unfortunately, not all patients are eligible for liver resection. Moreover, there are significa
PMID 23406440

Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection.

Chen X, Zhang B, Yin X, Ren Z, Qiu S, Zhou J.SourceLiver Cancer Institute, Shanghai, China.
Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.2013 May;139(5):773-81. doi: 10.1007/s00432-012-1343-7. Epub 2013 Feb 3.
PURPOSE: To explore the effect of lipiodolized transarterial chemoembolization (lip-TACE) in hepatocellular carcinoma (HCC) patients at different risk of recurrence after curative resection.METHODS: One thousand nine hundred and twenty-four consecutive HCC patients who underwent curative resection w
PMID 23377952

Japanese Journal

Transarterial Embolization With Use of Lipiodol and Gelatin Sponge for Active Nasal Bleeding From Hepatocellular Carcinoma Metastasis in the Pituitary Gland : Case Report

TAKIGAWA Tomoji,MATSUMARU Yuji,HAYAKAWA Mikito,IKEDA Kenji,MATSUMURA Akira
Neurologia medico-chirurgica = 神経外科 51(8), 592-595, 2011-08-15
… A 58-year-old man presented with a very rare case of pituitary metastasis from hepatocellular carcinoma with active nasal bleeding which was treated by transarterial embolization using ethiodized oil (Lipiodol) and gelatin sponge. …
NAID 10029338356

Related Pictures

[1] Ahrar, K.; Gupta, S. (Jan 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes.". Surg Oncol Clin N Am 12 (1): 105–26. doi:10.1016/s1055-3207(02)00089-3. PMID 12735133.

[2] Sato, T. (Apr 2002). "Locoregional immuno(bio)therapy for liver metastases.". Semin Oncol 29 (2): 160–7. doi:10.1053/sonc.2002.31716. PMID 11951214.

[3] Guan, YS.; Hu, Y.; Liu, Y. (Jun 2006). "Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization.". J Gastroenterol Hepatol 21 (6): 941–6. doi:10.1111/j.1440-1746.2006.04474.x. PMID 16724976.

[4] Cabanas, RM. (2000). "The concept of the sentinel lymph node.". Recent Results Cancer Res 157: 109–20. doi:10.1007/978-3-642-57151-0_9. PMID 10857165.

[Johnson-2005-5] Johnson, NP. (2005). "A review of the use of lipiodol flushing for unexplained infertility.". Treat Endocrinol 4 (4): 233–43. doi:10.2165/00024677-200504040-00004. PMID 16053340.

[6] ttp://www.guerbet-us.com/?page=lipiodol

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