ethanolaminephosphotransferase

エタノールアミンホスホトランスフェラーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/18 21:18:27」(JST)

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ethanolaminephosphotransferase
Identifiers
EC number	2.7.8.1
CAS number	9026-19-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an ethanolaminephosphotransferase (EC 2.7.8.1) is an enzyme that catalyzes the chemical reaction

CDP-ethanolamine + 1,2-diacylglycerol CMP + a phosphatidylethanolamine

Thus, the two substrates of this enzyme are CDP-ethanolamine and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. Other names in common use include EPT, diacylglycerol ethanolaminephosphotransferase, CDPethanolamine diglyceride phosphotransferase, and phosphorylethanolamine-glyceride transferase. This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

• KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222: 193–214. PMID 13366993. 

English Journal

• Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men.

• Hobbs MM1, Anderson JE, Balthazar JT, Kandler JL, Carlson RW, Ganguly J, Begum AA, Duncan JA, Lin JT, Sparling PF, Jerse AE, Shafer WM.
• mBio.MBio.2013 Nov 19;4(6):e00892-13. doi: 10.1128/mBio.00892-13.
• Phosphoethanolamine (PEA) on Neisseria gonorrhoeae lipid A influences gonococcal inflammatory signaling and susceptibility to innate host defenses in in vitro models. Here, we evaluated the role of PEA-decorated gonococcal lipid A in competitive infections in female mice and in male volunteers. We i
• PMID 24255126

• The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin.

• Wanty C1, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A.
• Journal of molecular biology.J Mol Biol.2013 Sep 23;425(18):3389-402. doi: 10.1016/j.jmb.2013.06.029. Epub 2013 Jun 28.
• Gram-negative bacteria possess an outer membrane envelope consisting of an outer leaflet of lipopolysaccharides, also called endotoxins, which protect the pathogen from antimicrobial peptides and have multifaceted roles in virulence. Lipopolysaccharide consists of a glycan moiety attached to lipid A
• PMID 23810904

• Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen.

• Vacaru AM1, van den Dikkenberg J, Ternes P, Holthuis JC.
• The Journal of biological chemistry.J Biol Chem.2013 Apr 19;288(16):11520-30. doi: 10.1074/jbc.M113.460972. Epub 2013 Feb 28.
• Sphingomyelin (SM) is a vital component of mammalian membranes, providing mechanical stability and a structural framework for plasma membrane organization. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase in the Golgi
• PMID 23449981

Japanese Journal

• Cloning and expression of a human choline/ethanolaminephosphotransferase : synthesis of phosphatidylcholine and phosphatidylethanolamine

• HENNEBERRY A. L.
• Biochem. J. 339, 291-298, 1999
• NAID 80011050467

• Utilization of diacylglycerol species by cholinephosphotransferase, ethanolaminephosphotransferase and diacylglycerol acyltransferase in rat liver microsomes.

• DE KRUYFF B.
• Biochim. Biophys. Acta 210, 425-435, 1970
• NAID 30010395770

Related Links

• Ethanolaminephosphotransferase | definition of ...

Meaning of ethanolaminephosphotransferase medical term. What does ethanolaminephosphotransferase mean? Ethanolaminephosphotransferase | definition of ethanolaminephosphotransferase by Medical dictionary http://medical ...

• Ethanolaminephosphotransferase - Springer

EC number 2.7.8.1 Systematic name CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase Recommended na ... Morimoto, K.; Kanoh, H.: Acyl chain length dependency of diacylglycerol cholinephosphotransferase ...

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ethanolaminephosphotransferase