etanidazole

エタニダゾール

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/03 23:41:51」(JST)

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Etanidazole
IUPAC name N-(2-Hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
Identifiers
CAS number	22668-01-5 N
PubChem	3276
ChemSpider	3161 Y
ChEMBL	CHEMBL47405 Y
Jmol-3D images	Image 1
SMILES O=[N+]([O-])c1nccn1CC(=O)NCCO
InChI InChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13) Y Key: WCDWBPCFGJXFJZ-UHFFFAOYSA-N Y
Properties
Molecular formula	C7H10N4O4
Molar mass	214.18 g mol−1
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Etanidazole is a nitroimidazole drug used for its radiosensitizing properties. Administration of etanidazole results in a decrease of glutathione concentration and inhibits glutathione S-transferase. The result is that tissues become more sensitive to the ionizing radiation used in cancer treatment.

See also

• EF5, a related nitroimidazole

References

English Journal

• The end of the hypoxic EPOch.

• Aguilera TA1, Giaccia AJ2.
• International journal of radiation oncology, biology, physics.Int J Radiat Oncol Biol Phys.2015 Apr 1;91(5):895-7. doi: 10.1016/j.ijrobp.2015.01.041.
• PMID 25832683

• Pharmacokinetic and pharmacodynamic modifiers of EF5 uptake and binding.

• Koch CJ1, Evans SM1.
• Journal of nuclear medicine : official publication, Society of Nuclear Medicine.J Nucl Med.2015 Apr;56(4):653. doi: 10.2967/jnumed.114.151662. Epub 2015 Mar 5.
• PMID 25745093

• Reply: Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding.

• Chitneni SK1, Bida GT1, Zalutsky MR1, Dewhirst MW1.
• Journal of nuclear medicine : official publication, Society of Nuclear Medicine.J Nucl Med.2015 Apr;56(4):653-4. doi: 10.2967/jnumed.115.154054. Epub 2015 Mar 5.
• PMID 25745087

Japanese Journal

• Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo

• Journal of radiation research 52(2), 208-214, 2011-03-16
• NAID 10027956760

• 2-ニトロイミダゾールアセトアミド誘導体の低酸素ヒト肺癌細胞に対する放射線増感効果

• 日本放射線影響学会大会講演要旨集 2008(0), 238-238, 2008
• NAID 130006999358

• Radiosensitization by the Combination of SR-2508 and Paclitaxel in Hypoxic Human Tumor Cells in vitro

• Journal of radiation research 48(3), 179-185, 2007-06-30
• NAID 110006278192

Related Links

• Etanidazole | CAS 22668-01-5 | サンタクルーズバイオテック

Buy Etanidazole (CAS 22668-01-5), a biochemical for proteomics research, from Santa Cruz. Molecular Formula: C7H10N4O4, Molecular Weight: 214.18 ... 試験・研究用以外には使用しないでください。 臨床及び体外診断には使用 ...

• Etanidazole CAS# 22668-01-5 API Supplier Distributor, LGM ...

LGM Pharma is an Etanidazole CAS# 22668-01-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more. ... LGM Pharma is a Etanidazole 22668-01-5 active ...

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