出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/01 20:06:53」(JST)
| Epilepsy | |
|---|---|
| Classification and external resources | |
Generalized 3 Hz spike and wave discharges on an EEG
|
|
| ICD-10 | G40-G41 |
| ICD-9 | 345 |
| DiseasesDB | 4366 |
| MedlinePlus | 000694 |
| eMedicine | neuro/415 |
| MeSH | D004827 |
Epilepsy (from the Ancient Greek verb ἐπιλαμβάνειν meaning "to seize, possess, or afflict")[1] is a group of long term neurological disorders characterized by epileptic seizures.[2] These seizures are episodes which vary from brief and nearly undetectable to long periods of vigorous shaking.[3] Seizures due to epilepsy tend to recur and have no immediate cause[2] while seizures that occur right around a specific cause are not deemed to be epilepsy.[4]
The cause in most cases is unknown, while some are the result of brain trauma, stroke, brain cancer, and drug and alcohol misuse among others. Epileptic seizures are the result of excessive and abnormal cortical nerve cell activity in the brain.[4] The diagnosis typically involves ruling out other conditions that might cause similar symptoms (such as syncope) as well as figuring out if any immediate causes are present. Epilepsy can sometimes be confirmed with an electroencephalogram.
Epilepsy is controllable, but not cured, with medication in about 70% of cases.[5] In those who do not get control surgery, neurostimulation or dietary changes may be considered. Not all epilepsy syndromes are lifelong, and a substantial number of people improve to the point that medication is no longer needed.
About 1% of people worldwide (65 million) have epilepsy,[6] and nearly 80% of cases occur in developing countries.[3] Epilepsy becomes more common as people age.[7][8] Onset of new cases occurs most frequently in infants and the elderly in the developed world[9] and in older children and young adults in the developing world.[10] About 5–10% of all people will have an unprovoked seizure by the age of 80,[11] and the chance of experiencing a second seizure is between 40% and 50%.[12]
Epilepsy is characterized by a long-term risk of recurrent seizures.[13] These seizures may present in several ways depending on the part of the brain involved and the person's age.[14][13]
The most common type (60%) of seizures are convulsive.[14] Of these, two-thirds begin as focal seizures (which may than become generalized) while one-third begin as generalized seizures.[14] The remaining 40% of seizures are non-convulsive. An example of this type is the absence seizure, which presents as a decreased level of consciousness and usually lasts about 10 seconds.[15][16]
About 6% of those with epilepsy have seizures that are often triggered by specific events, known as reflex seizures.[17] Those with reflex epilepsy have seizures that are only triggered by specific stimuli.[18] Common triggers include flashing lights and sudden noises.[17] In certain types of epilepsy, seizures happen more often during sleep,[19] and in other types they occur almost only when sleeping.[20]
Loss of bowel or bladder control may occur.[3] The tongue may be bitten at either the tip or on the sides during a seizure.[21] In tonic-clonic seizure, bites to the sides are more common.[21] Tongue bites are also relatively common in psychogenic non-epileptic seizures.[21]
Epilepsy can have adverse effects on social and psychological well-being.[14] These effects may include social isolation, stigmatization, or disability.[14] They may result in lower educational achievement and worse employment outcomes.[14] Learning difficulties are common in those with the condition, and especially among children with epilepsy.[14] The stigma of epilepsy can also affect the families of those with the disease.[3]
Certain disorders occur more often in people with epilepsy, depending partly on the epilepsy syndrome present. These include: depression, anxiety disorders, and migraines.[22] Attention-deficit hyperactivity disorder affects three to five times more children with epilepsy than children in the general population.[23] ADHD and epilepsy have significant consequences on a child's behavioral, learning, and social development.[24] Epilepsy is also more common in those with autism.[25]
Epilepsy is not a single disease but a symptom that can result from a number of different disorders.[14] By definition the seizures occur spontaneously and without an immediate cause.[6] The underlying cause may be identified as genetic or as due to structural or metabolic problems, but in 60%[3][14] of cases the cause is unknown.[26] Seizures may also occur as a result of other health problems.[27] Epileptic seizures that occur right around a specific cause, such as a stroke, head injury, toxic ingestion or metabolic problem, are known as acute symptomatic seizures and are in the broader classification of seizure-related disorders rather than epilepsy itself.[6][28] Genetic, congenital, and developmental conditions are more common among younger people, while tumors and strokes are more likely in older people.[14]
Epilepsy may occur as a result of a number of other conditions including: tumors, strokes, head trauma, infections of the central nervous system, genetic abnormalities, and as a result of brain damage around the time of birth.[3][27] Of those with brain tumors, almost 30% have epilepsy, making them the cause of about 4% of epilepsy cases.[29] The risk is greatest for tumors in the temporal lobe and those that grow slowly.[29] Other mass lesions such as cerebral cavernous malformations and arterial venous malformations have risks as high as 40-60%.[29] Of those who have had a stroke, 2-4% develop epilepsy.[29] In the United Kingdom strokes account for 15% of cases[14] and it is believed to be the cause in 30% of the elderly.[29] Between 6% and 20% of epilepsy is believed to be due to head trauma.[29] Mild brain injury increases the risk about twofold while severe brain injury increases the risk sevenfold.[29] In those who have experienced a high powered gunshot wound to the head, the risk is about 50%.[29]
The risk of epilepsy following meningitis is less than 10%, but more commonly causes seizures during the infection itself.[29] In herpes simplex encephalitis the risk of a seizure is around 50%.[29] Infection with the port tapeworm, which can result in neurocysticercosis, is the cause of up to half of epilepsy cases in areas of the world where the parasite is common.[29] As well, epilepsy may occur after other brain infections such as cerebral malaria, toxoplasmosis, and toxocariasis.[29] Chronic alcohol use increases the risk of epilepsy: those who drink six drinks per day have a two and a half fold increase in risk.[29] Other risks include Alzheimer's disease, multiple sclerosis, tuberous sclerosis, and autoimmune encephalitis.[29] Getting vaccinated does not increase the risk of epilepsy.[29] Malnutrition is a risk factor seen mostly in the developing world.[10]
Genetics is believed to be involved in the majority of cases, either directly or indirectly.[30] Some epilepsies are due to a single gene defect (1-2%); most are due to the interaction of multiple genes and environmental factors.[30] Some of the genes involved affect ion channels, enzymes, GABA, and G protein-coupled receptors.[31]
In identical twins, if one is affected there is a 50-60% chance that the other will also be affected.[30] In non-identical twins the risk is 15%.[30] These risks are greater in those with generalized than focal seizures.[30] If both twins are affected, most of the time they have the same epileptic syndrome (70-90%).[30] Close relatives have a risk five times that of the general population.[29] Between 1-10% of those with Down syndrome and 90% of those with Angelman syndrome have epilepsy.[29]
There are a number of epilepsy syndromes grouped by age of onset into: neonatal period, childhood, adulthood, and those with no strong age relationship.[27] Additionally there are groups with specific constellations of symptoms, those due to specific metabolic or structural causes, and those of unknown cause.[27] The ability to classify a case of epilepsy into specific syndrome occurs more often with children.[28] Some types include: benign rolandic epilepsy (2.8 per 100,000), childhood absence epilepsy (0.8 per 100,000) and juvenile myoclonic epilepsy (0.7 per 100,000).[28] Febrile seizures and benign neonatal seizures are not forms of epilepsy.[27]
Normally brain electrical activity is non synchronous.[15] In epileptic seizures, due to problems within the brain,[3] a group of neurons begin firing in an abnormal, excessive,[14] and synchronized manner.[15] This results in a wave of depolarization known as a paroxysmal depolarizing shift.[32]
Normally after an excitatory neuron fires it becomes more resistant to firing for a period of time.[15] This is due in part from the effect of inhibitory neurons, electrical changes within the excitatory neuron, and the negative effects of adenosine.[15] In epilepsy the resistance of excitatory neuron's to fire during this period is decreased.[15] This may occur due to changes in ion channels or inhibitory neurons not functioning properly.[15] This then results in a specific area from which seizures may develop, known as a "seizure focus".[15] Another cause of epilepsy may be the up regulation of excitatory circuits or down regulation of inhibitory circuits follow an injury to the brain.[15][33] These secondary epilepsies, occur through processes known as epileptogenesis.[15][33] Failure of the blood–brain barrier may also be a causal mechanism.[34]
Focal seizures begin in one hemisphere of the brain while generalized seizures begin in both hemispheres.[27] Some types of seizures may change brain structure, while others appear to have little effect.[35] Gliosis, neuronal loss, and atrophy of specific areas of the brain are linked to epilepsy but it is unclear if epilepsy causes these changes or if these changes result in epilepsy.[35]
The diagnosis of epilepsy is typically made based on the a description of the seizure and surrounding events.[14] An electroencephalogram and neuroimaging are also usually part of the workup.[14] While figuring out a specific epileptic syndrome is often attempted, it is not always possible.[14] Video and EEG monitoring may be useful in difficult cases.[36]
In practice epilepsy is defined as two or more epileptic seizures, separated by more than 24 hours, without a clear cause; where an epileptic seizure is defined as temporary signs and symptoms resulting from abnormal electrical activity within the brain.[6] It can also be viewed as a disorder in which people have had at least one epileptic seizure with an ongoing risk of having more.[6]
Officially the International League Against Epilepsy defines epilepsy as "a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition. The definition of epilepsy requires the occurrence of at least one epileptic seizure".[37]
Those with seizures should be classified by seizure type, underlying cause, epilepsy syndrome, and events during and around the time of the seizures.[36] Seizure types are organized by whether the source of the seizure is localized (focal seizures) or distributed (generalized seizures) within the brain.[27] Focal seizures were previously known as partial seizures.[14] Generalized seizures are divided according to the effect on the body and include: tonic-clonic (grand mal), absence (petit mal), myoclonic, clonic, tonic, and atonic seizures.[27][38] Some seizures are of an unknown type such as epileptic spasms.[27]
Focal seizures were previously divided into simple partial or complex partial seizure.[27] This is no longer recommended with the preference to describe what has occurred during a seizure.[27]
In adults testing electrolytes, blood glucose and calcium levels is important to rules these out as causes.[36] As is an electrocardiogram.[36] A lumbar puncture may be useful to diagnose a central nervous system infection but is not routinely needed.[11] Routine antiseizure medical levels in the blood are not required in adults or children.[36] In children additional tests may be required.[36]
A high blood prolactin level within the first 20 minutes following a seizure may be useful to confirm an epileptic seizure as opposed to psychogenic non-epileptic seizure.[39][40] Serum prolactin level is less useful for detecting partial seizures.[41] If it is normal an epileptic seizure is still possible[40] and a serum prolactin does not separate epileptic seizures from syncope.[42] It is not recommended as a routine part of diagnosis epilepsy.[36]
An electroencephalography is only recommended in those who likely had an epileptic seizure and may help determine the type of seizure or syndrome present. In children it is typically only needed after a second seizure. It cannot be used to rule out the diagnosis and may be falsely positive in those without the disease. It certain situations it may be useful to prefer the EEG while sleeping or sleep deprived.[36]
Diagnostic imaging by CT scan and MRI is recommended after a first non-febrile seizure to detect structural problems inside the brain.[36] MRI is generally a better imaging test except when intracranial bleeding is suspected.[11] Imaging may be done at a later point in time in those who return to there normal selves while in the emergency room.[11] If a person has a previous diagnosis of epilepsy with previous imaging repeat imaging is not usually needed with subsequent seizures.[36]
Diagnosis is difficult and misdiagnosis is frequent (occurring is about 5 to 30% of cases).[14] A number of other conditions may present very similar to epilepsy including: syncopy, hyperventillation, and psychogenic non-epileptic seizures (PNES).[43] Approximately one in five people seen at epilepsy clinics have PNES.[11]
Children may have behaviors that are easily mistaken for epileptic seizures but are not. This include: inattentive staring, benign shudders (among children younger than age 2, usually when they are tired or excited), self-gratification behaviors (nodding, rocking, head banging), and conversion disorder (flailing and jerking of the head). Conversion disorder can be distinguished from epilepsy as the episodes never occur during sleep and do not involve incontinence or self-injury.[44]
While many cases are not preventable, decreasing head injuries, good care around the time of birth, and reducing environmental parasites such as Taenia solium, the cause of neurocysticercosis, may be effective.[3] Efforts in Central America to decrease rates of Taenia solium resulted in a 50% decrease in new cases of epilepsy.[10]
Epilepsy is usually treated with daily medication once a second seizure has occurred.[14][36] In those with high risk features they may be started after a first seizure.[36] In some cases a special diet, the implantation of a neurostimulator, or neurosurgery can be helpful.
Those who are having an active tonic-clonic seizure should be rolled on their side into the recovery position to prevent fluids from getting into the lungs.[45] Putting fingers, a bite block or tongue depressor in the mouth is not recommended as it might make the person vomit or result in the rescuer being bitten.[46][45] The person should be prevented from further self-injury.[46] Spinal precautions are generally not needed.[45]
If a seizure lasts longer than 5 minutes or if there are more than two seizures in an hour it is a medical emergency.[36] This may require airway management.[36] A nasopharyngeal airway may be useful for this.[45] The recommended initial medication for seizure of a long duration is midazolam placed in the check.[47] Diazepam rectally may also be used.[47] In hospital intravenous lorazepam is preferred.[36] If two doses of benzodiazepines are not effective other medications such as phenytoin or pentobarbital are recommended.[36]
The mainstay of treatment of epilepsy is anticonvulsant medications, typically for the person's entire life.[14] The choice of anticonvulsant is based on seizure type, epilepsy syndrome, other medications and health problems, and the person's age and lifestyle.[47] A single medication is recommended initially[48] and if this is not effective a single other medication is than recommended.[36] Two medications at once is only recommended if a single medication does not work.[36] The first agent tried works in about half of people, while a second agent helps in about 13% and a third or two agents at the same time may help an additional 4%.[49] About 30% of people continue to have seizures despite anticonvulsant treatment.[5]
There are a number of medications available. Phenytoin, carbamazepine and valproate appear to be equally effect in both focal and generalized seizures.[50][51] Controlled release carbamazepine appears to work as well as immediate release carbamazepine however may have less side effects.[52] In the United Kingdom carbamazepine or lamotrigine is recommended first line for focal seizure with levetiracetam and valproate being second line due to issues of cost and side effects.[36] Valproate is recommended first line for generalized seizures with lamotrigine being second line.[36] In those with absence seizures ethosuximide or valproate is recommended while in myoclonic seizures and tonic or atonic seizures valproate is recommended.[36] The least expensive anticonvulsant is phenobarbital at less than $15 USD a year.[10] The World Health Organization recommends it first line and it is commonly used in the developing world.[53] Access however may be difficult as some countries label it as a controlled drug.[10]
Adverse effects are reported in between 10 to 90% of people depending on how and in whom the data is collected.[54] Most adverse effects are dose-related and mild.[54] Some examples include mood changes, sleepiness, or unsteadiness in gait.[54] Some medications have side effects that are not related to dose such as rashes, liver toxicity, or low red blood cells.[54] up to a quarter of people stop treatment due to adverse effects.[54] Some medications may cause birth defects when used in pregnancy.[36] Valproate is of particular concern especially during the first trimester.[55] The risk of untreated epilepsy however is believed to be great than the risk of the medications.[55]
Slowly stopping medications may be reasonable in some people who do not have a seizure for two to four years; however around a third of people have a recurrence, most often occurring in the first six months.[36][56] Stopping is possible in about 70% of children and 60% of adults.[3]
Epilepsy surgery may be an option for people with focal seizures that remain a problem despite other treatments.[57] These other treatments include at least a trial of two or three medications.[58] The goal of surgery is total control of seizures,[59] and this may be achieved in 60-70% of cases.[58] Common procedures include: cutting out the hippocampus via an anterior temporal lobe resection, removal of tumors, and removing parts of the neocortex.[58] Some procedures such as a corpus callosotomy are attempted in an effort to decrease the number of seizures rather than cure the condition.[58] Following surgery medications may be slowly stopped in many.[58]
Neurostimulation maybe another option in those who are not candidates for surgery.[36] Three types shown to be effective in those who do not respond to medications: vagus nerve stimulation, anterior thalamic stimulation, and closed-loop responsive stimulation.[60]
A ketogenic diet (high-fat, low-carbohydrate, adequate-protein) appears to decrease the number of seizures by half in about 30-40% of children.[61] About 10% manage to stay on the diet for a few years, 30% had constipation, and other adverse effects were common.[61] Less radical diets were easier to tolerate and may be effective.[61] It is unclear why this diet works.[62]
Avoidance therapy consists of minimizing or eliminating triggers. For example in those who are sensitive to light using a small television, avoiding video-games or wearing dark glasses may be useful.[63] Some claim that seizure response dogs, a form of service dog, can predict seizures. Evidence for this, however, is poor.[64] Operant-based biofeedback based on the EEG waves has some support in those who do not respond to medications.[65] Psychological methods should not; however, be used to replace medications.[36]
Alternative medicine, including acupuncture,[66] psychological interventions,[67] vitamins,[68] and yoga,[69] have no reliable evidence to support their use in epilepsy. Exercise has been proposed as possibly useful for preventing seizures[70] with some data to support this claim.[71] The use of cannabis is not supported by the evidence.[72]
Disability-adjusted life year for epilepsy per 100,000 inhabitants in 2004.
|
no data
<50
50-72.5
72.5-95
95-117.5
117.5-140
140-162.5
|
162.5-185
185-207.5
207.5-230
230-252.5
252.5-275
>275
|
Of those with generalized seizure more than 80% can be well controlled with medications. This is true in only 50% of people with focal seizures.[60] One predictors of long term outcomes is the number of seizures that occurs in the first six months.[14] Other factors increasing the risk of a poor outcome include: little response to the initial treatment, generalized seizures, a family history of epilepsy, psychiatric problems, and waves on the EED representing generalized epileptiform activity.[73] In the developing world 75% of people are either untreated or not appropriately treated.[3] In Africa 90% do not get treatment.[3] This is partly related to appropriate medications not being available or being too expensive.[3]
People with epilepsy are at an increased risk of death.[74] This increase is between 1.6 and 4.1 fold greater[75] and is often related to: the underlying cause of the seizures, status epilepticus, suicide, trauma, and sudden unexpected death in epilepsy (SUDEP).[74] Death from status epilepticus is primarily due to an underlying problem rather than missing doses of medications.[74] The risk of suicide is increased between two and six times in those with epilepsy.[76][77] The cause of this is unclear.[76] SUDEP appears to be partly related to the frequency of generalized tonic-clonic seizures[78] and accounts for about 15% of epilepsy related deaths.[73] It is unclear how to decrease its risk.[78] The greatest increase in mortality from epilepsy is among the elderly.[75] While those with epilepsy due to an unknown cause have little risk.[75] In the United Kingdom it is estimated that 40-60% of deaths are possibly preventable.[14] In the developing world many deaths are due to untreated epilepsy leading to falls or status epilepticus.[10]
Epilepsy is one of the most common serious neurological disorders[79] affecting about 65 million people.[6] It affects 1% of the population by age 20 and 3% of the population by age 75.[80] It is more common in males than females with this difference being small.[10][28] Most of those with the disease (80%) are in the developing world.[3]
The number of people who currently have active epilepsy is in the range 5–10 per 1000, were active epilepsy is defined as someone with epilepsy who has had a least one seizure in the last five years.[81][28] Epilepsy begins each year in 40–70 per 100,000 in developed countries and 80–140 per 100,000 in developing countries.[3] Poverty is a risk and includes both being from a poor country and relative to others within ones country.[10] In the developed world epilepsy most commonly starts either in the young or in the old.[10] In the developing world its onset is more common in older children and young adults due to the higher rates of trauma and infectious diseases.[10] In developed countries the number of cases a year has decreased in children and increased among the elderly between the 1970s and 2003.[81] This has been attributed partly to better survival following strokes in the elderly.[28]
The oldest medical records show that epilepsy has been affecting people since the beginning of recorded history.[82] Throughout ancient history, the disorder was thought to be a spiritual condition.[82] The world's oldest description of an epileptic seizure comes from a text in Akkadian (a language used in ancient Mesopotamia) and was written about 2000 BCE.[1] The person described in the text was diagnosed as being under the influence of a Moon god, and underwent an exorcism.[1] Epileptic seizures are listed in the Code of Hammurabi (c. 1790 BCE) as reason for which a purchased slave may be returned for a refund,[1] and the Edwin Smith Papyrus (c. 1700 BCE) describes cases of individuals with epileptic convulsions.[1]
The oldest known detailed record of the disorder itself is in the Sakikkū, a Babylonian cuneiform medical text from 1067–1046 BCE.[82] This text gives signs and symptoms, details treatment and likely outcomes,[1] and describes many features of the different seizure types.[82] As the Babylonians had no biomedical understanding of the nature of disease, they attributed the seizures to possession by evil spirits and called for treating the condition through spiritual means.[82] Around 900 BCE, Punarvasu Ātreya described epilepsy as loss of consciousness;[83] this definition was carried forward into the Ayurvedic text of Charaka Samhita (about 400 BCE).[84]
The ancient Greeks had contradictory views about the disease. They thought of epilepsy as a form of spiritual possession, but also associated condition with genius and the divine. One of the names they gave to it was the sacred disease. The disease appears within Greek mythology: it is associated with the Moon goddesses Selene and Artemis, who afflicted those who upset them. The Greeks thought that important figures such as Julius Caesar and Hercules had the disease.[1]
The notable exception to this divine and spiritual view was that of the school of Hippocrates. In the fifth century BCE, Hippocrates rejected the idea that the disease was caused by spirits. In his landmark work On the Sacred Disease, he proposed that epilepsy was not divine in origin and instead was a medically treatable problem originating in the brain.[1][82] He accused those of attributing a sacred cause to the disease of perpetuating ignorance through a belief in superstitious magic.[1] Hippocrates proposed that heredity was important in the passing of the disease, described a worse prognosis if the disease presents at an early age, and made note of the physical characteristics of the disease as well as the social shame associated with it.[1] Instead of referring to it as the sacred disease, he used the term great disease, giving rise to the modern term grand mal, used for a type of seizure.[1] Despite his work detailing the physical origins of the disease, his view was not accepted at the time.[82] Evil spirits continued to be blamed until at least the 17th century.[82]
In most cultures, persons with epilepsy have been stigmatized, shunned, or even imprisoned; in the Salpêtrière, the birthplace of modern neurology, Jean-Martin Charcot found people with epilepsy side-by-side with the mentally handicapped, those with chronic syphilis, and the criminally insane. In Tanzania to this day, as with other parts of Africa, epilepsy is associated with possession by evil spirits, witchcraft, or poisoning and is believed by many to be contagious.[85] In ancient Rome, epilepsy was known as the Morbus Comitialis ('disease of the assembly hall') and was seen as a curse from the gods. In northern Italy, epilepsy was once traditionally known as Saint Valentine's Malady.[86]
In the mid 1800s the first effective anti seizure medication, bromide, was introduced.[54] The first modern treatment, phenobarbital, was developed in 1912, with phenytoin coming into use in 1938.[87]
Stigma is commonly experienced, around the world, by those with epilepsy.[88] It can affect people economically, socially and culturally.[88] In India and China epilepsy may be used as justification to deny marriage.[3] Before 1970 the United Kingdom had laws which prevented people with epilepsy from marrying.[3] In some areas of the world epilepsy is believed to be contagious, which it is not.[10] Others still believe those with epilepsy to be cursed.[10] The stigma may result in some people with epilepsy denying that they have ever had seizures.[28]
Seizures result in direct economic costs of about one billion dollars in the United States.[11] Epilepsy results in economic costs in Europe of around 15.5 billion Euros in 2004.[14] In India epilepsy is estimated to result in costs of 1.7 billion USD or 0.5% of the GDP.[3] They make up about 1% of emergency department visits (2% for emergency departments for children) in the United States.[89]
Those with epilepsy are at about twice the risk of being involved in a motor vehicular collision and thus in many areas of the world are not allowed to drive or only able to drive if certain conditions are met.[90] In some places physicians are require by law to report if a person has had a seizure to the licensing body while in others the requirement is only that they encourage the person in question to report it themselves.[90] Countries that require physician reporting include: Sweden, Austria, Denmark and Spain.[90] Countries that require the individual to report include: the UK, and New Zealand and the physician may report if they believe the individual has not already.[90] In Canada, the United States and Australia the requirements around reporting vary by province or state.[90] If seizures are well controlled most feel allowing driving is reasonable.[91] The amount of time a person must be free from seizures before they can drive varies by country.[91] Many countries require between one to three years without seizures.[91] In the United States the time needed without a seizure is determined by the state and is between three months and one year.[91]
A pilots license is typically denied in anyone with epilepsy or seizures.[92] In Canada if an individual has had one seizure but no others they may be considered after five years for a limited license if all other testing is normal.[93] Those with febrile seizures and drug related seizures may also be considered.[93] In the United States, the Federal Aviation Administration does not allow those with epilepsy to get a commercial pilots license.[94] They may make rare exceptions for persons who have had an isolated seizure or febrile sizures and have remained free of seizures into adulthood without medication.[95] In the United Kingdom, a full national private pilot license, requires the same standards as a professional drivers license.[96] This requires a period of ten years without seizures while off medications.[97] In those who do not meet this requirement a restricted license may be acquired if free from seizures for five years.[96]
There are a number of non-profit organizations that provide support to people and families effected by epilepsy. In the UK this includes the Joint Epilepsy Council of the UK and Ireland.[36] Purple day was established in 2008 to increase awareness around epilepsy and occurs on March 28.[98] Other efforts to increase knowledge include the "Out of the Shadows" campaign by the World Health Organization, International League Against Epilepsy and the International Bureau for Epilepsy.[3]
Melatonin and medications which alter immune function such as intravenous immunoglobulin are insufficiently supported by evidence.[99][100] Gene therapy is being studied in some types of epilepsy.[101] Noninvasive stereoctatic radiosurgery is, as of 2012, being compared to standard surgery for certain types of epilepsy.[102] Seizure prediction refers to attempts to forecasting epileptic seizures based on the EEG before they occur.[103] As of 2011, there has been no effective mechanism that predicts seizures.[103]
Epilepsy occurs in a number of other animals including dogs and cats and is the most common brain disorder in dogs.[104]
|date= (help)|date= (help)| Wikimedia Commons has media related to Epilepsy. |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.