てんかん重積状態 status epilepticus

WordNet

of or relating to or characteristic of epilepsy; "epileptic seizure"
a person who has epilepsy

PrepTutorEJDIC

てんかん[性]の / てんかん患者

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1. 成人における痙攣性のてんかん重積状態：治療および予後 convulsive status epilepticus in adults treatment and prognosis
2. 成人における痙攣性のてんかん重積状態：分類、臨床症状、および診断 convulsive status epilepticus in adults classification clinical features and diagnosis
3. 小児におけるてんかん重積状態の臨床的特徴および合併症 clinical features and complications of status epilepticus in children
4. 非痙攣性てんかん重積状態 nonconvulsive status epilepticus
5. 小児における痙攣を伴うてんかん重積状態のマネージメント management of convulsive status epilepticus in children

English Journal

The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus.

Matos G1, Scorza FA2, Mazzotti DR1, Guindalini C1, Cavalheiro EA2, Tufik S1, Andersen ML3.Author information 1Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil.2Departamento de Neurologia Experimental, Universidade Federal de São Paulo, Brazil.3Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil. Electronic address: ml.andersen12@gmail.com.AbstractEpilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathophysiological mechanisms involved in this lethal phenomenon are still obscure and new evidences that could corroborate in this area are warranted. Thus, the aim of the present study was to evaluate the effect of sleep deprivation in the expression of microRNA (miRNA) in the frontal cortex and heart tissues of adult male rats after 50days of saline (SAL) or pilocarpine-induced status epilepticus (PILO). Initially 389 miRNA expressions were evaluated between SAL and PILO groups by microarray. Subsequently, 3 differentially expressed miRNAs of each tissue were investigated after total sleep deprivation (TSD 6h) and paradoxical sleep deprivation (PSD 24h). Still, it was analyzed that the effects of sleep rebound with equivalent duration of PSD and TSD. There was a significant increase of miR-146a expression, an important inflammatory modulator in the frontal cortex of PILO rats when compared to SAL animals. Animals treated with pilocarpine were affected by TSD (through overexpression of miRNAs related to inflammatory process) and these changes were maintained even after a sleep window of 6h. In contrast, miRNAs associated with heart diseases were down-regulated in PSD rebound, suggesting a possible restoration of homeostasis in cardiovascular system of SAL and PILO groups.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Jun 3;51:159-65. doi: 10.1016/j.pnpbp.2014.02.001. Epub 2014 Feb 11.
Epilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathoph
PMID 24530830

Clinical and electroencephalographic findings in acutely ill adults with non-convulsive vs convulsive status epilepticus.

Pollak L1, Gandelman-Marton R, Margolin N, Boxer M, Blatt I.Author information 1Department of Neurology, The Assaf Harofeh Medical Center, Zerifin, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.AbstractBACKGROUND: Non-convulsive status epilepticus (NCSE) indicates a change in the mental state with no motor manifestations, being a clinical expression of prolonged epileptiform activity. In contrast to convulsive status epilepticus (CSE), no unified treatment recommendations have been proposed so far. We were interested to review the clinical and encephalographic characteristics in hospitalized patients with NCSE and CSE and compare their treatment and outcome.
Acta neurologica Scandinavica.Acta Neurol Scand.2014 Jun;129(6):405-11. doi: 10.1111/ane.12200. Epub 2013 Nov 13.
BACKGROUND: Non-convulsive status epilepticus (NCSE) indicates a change in the mental state with no motor manifestations, being a clinical expression of prolonged epileptiform activity. In contrast to convulsive status epilepticus (CSE), no unified treatment recommendations have been proposed so far
PMID 24571568

Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.

Liu W1, Shi R, Yang W, Zhao N, Du Y, Zou Y, Yu W.Author information 1Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.AbstractPurpose: Recent studies have shown that transforming growth factor β (TGFβ) signaling participates in the epileptogenesis. Serine-threonine kinase receptor-associated protein (STRAP) and Smad7 synergize in the inhibition of the TGFβ signaling. The aim of the present study was to determine the expression pattern of STRAP and Smad7 in the hippocampus and temporal lobe cortex of pilocarpine-induced rats models of epilepsy. Methods: Lithium chloride-pilocarpine-induced rats with status epilepticus (SE) were established. Total of 60 male Sprague-Dawley rats was used as control (n = 10), 24 h (n = 10), 72 h (n = 10), 1 week (n = 10), 1 month (n = 10), and 2 months (n = 10) after pilocarpine-induced SE, respectively. We detected the expression levels of STRAP and Smad7 in the hippocampus and temporal lobe cortex of rats at the aforementioned time points using western blotting and immunohistochemistry. Results: STRAP level was significantly decreased in 24 h, 72 h (acute stage), 1 week (latent stage), 1 month, 2 months (chronic stage), respectively, in the rat models compared with the control rats by using both western blotting and immunohistochemistry. Smad7 had similar reduced pattern as STRAP. Conclusions: Our results indicate that STRAP and Smad7 proteins might be involved in the development of temporal lobe epilepsy. Synapse 68:275-282, 2014. © 2014 Wiley Periodicals, Inc.
Synapse (New York, N.Y.).Synapse.2014 Jun;68(6):275-82. doi: 10.1002/syn.21739. Epub 2014 Mar 11.
Purpose: Recent studies have shown that transforming growth factor β (TGFβ) signaling participates in the epileptogenesis. Serine-threonine kinase receptor-associated protein (STRAP) and Smad7 synergize in the inhibition of the TGFβ signaling. The aim of the present study was to determine the exp
PMID 24577865