UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Generation of Epithelial Cell Populations from Human Pluripotent Stem Cells Using a Small-Molecule Inhibitor of Src Family Kinases.

Selekman JA1, Lian X, Palecek SP.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1307:319-27. doi: 10.1007/7651_2014_70.
Human pluripotent stem cells (hPSCs), under the right conditions, can be engineered to generate populations of any somatic cell type. Knowledge of what mechanisms govern differentiation towards a particular lineage is often quite useful for efficiently producing somatic cell populations from hPSCs.
PMID 24500899

Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes.

Sevilla LM1, Latorre V2, Carceller E1, Boix J1, Vodák D3, Mills IG4, Pérez P5.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Sep 5;412:281-9. doi: 10.1016/j.mce.2015.05.015. Epub 2015 May 19.
The glucocorticoid (GC) receptor (GR) and Kruppel-like factor Klf4 are transcription factors that play major roles in skin homeostasis. However, whether these transcription factors cooperate in binding genomic regulatory regions in epidermal keratinocytes was not known. Here, we show that in dexamet
PMID 26001834

Epidermal Micrografts Produced via an Automated and Minimally Invasive Tool Form at the Dermal/Epidermal Junction and Contain Proliferative Cells That Secrete Wound Healing Growth Factors.

Osborne SN1, Schmidt MA, Derrick K, Harper JR.
Advances in skin & wound care.Adv Skin Wound Care.2015 Sep;28(9):397-405. doi: 10.1097/01.ASW.0000470024.81711.b8.
OBJECTIVE: The aim of this scientific study was to assess epidermal micrografts for formation at the dermal-epidermal (DE) junction, cellular outgrowth, and growth factor secretion. Epidermal harvesting is an autologous option that removes only the superficial epidermal layer of the skin, considerab
PMID 26258460

Ishiguro-Oonuma Toshina,Ochiai Kazuhiko,Hashizume Kazuyoshi,Iwanaga Toshihiko,Morimatsu Masami
Japanese Journal of Veterinary Research 63(3), 107-114, 2015-08
… In skin from Nfkbiz－/－ mice, the expression of the keratinocyte differentiation markers K10 and filaggrin were reduced, although that of K14 was unchanged. … These findings indicate a novel possible role of Nfkbiz in controlling the proliferation and differentiation of epidermal keratinocytes through NF-κB-independent mechanisms. …
NAID 120005656352

Effects of Phosphoryl Oligosaccharides of Calcium (POs-Ca) on Epidermal Cells and Human Skin

井家益和,畠賢一郎
Organ Biology 22(1), 57-65, 2015
… The epidermal keratinocytes are obtained from trypsinization of fullthickness skin biopsy. … But the melanocytes cultured with keratinocyte by the Greenʼs method can only reconstruct an intercellular function. …
NAID 130005098700