WordNet

type genus of the family Cancridae (同)genus Cancer
the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 (同)Cancer the Crab, Crab
(astrology) a person who is born while the sun is in Cancer (同)Crab
a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream (同)malignant neoplastic disease

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1. ER／PR陰性、HER2陰性（トリプルネガティブ）乳癌の疫学、危険因子および臨床的アプローチ epidemiology risk factors and the clinical approach to er pr negative her2 negative triple negative breast cancer
2. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法 systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor
3. 転移性ホルモン受容体陽性乳癌に対する治療アプローチ：内分泌療法 treatment approach to metastatic hormone receptor positive breast cancer endocrine therapy
4. 表皮母斑および表皮母斑症候群 epidermal nevus and epidermal nevus syndrome
5. 乳癌治療後の患者へのアプローチ approach to the patient following treatment for breast cancer

Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization.

Kijanka MM1, van Brussel AS2,3, van der Wall E4, Mali WP5, van Diest PJ6, van Bergen En Henegouwen PM7, Oliveira S8,9.
EJNMMI research.EJNMMI Res.2016 Dec;6(1):14. doi: 10.1186/s13550-016-0166-y. Epub 2016 Feb 10.
BACKGROUND: Optical molecular imaging is an emerging novel technology with applications in the diagnosis of cancer and assistance in image-guided surgery. A high tumour-to-background (T/B) ratio is crucial for successful imaging, which strongly depends on tumour-specific probes that rapidly accumula
PMID 26860296

Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC.

Bahce I1, Yaqub M2, Errami H3, Schuit RC2, Schober P4, Thunnissen E5, Windhorst AD2, Lammertsma AA2, Smit EF3,6, Hendrikse NH2,7.
EJNMMI research.EJNMMI Res.2016 Dec;6(1):10. doi: 10.1186/s13550-016-0169-8. Epub 2016 Feb 9.
BACKGROUND: In non-small cell lung cancer (NSCLC) patients off erlotinib therapy, positron emission tomography (PET) using [(11)C]erlotinib distinguished epidermal growth factor receptor (EGFR) mutations from wild-type EGFR. However, tumor uptake of [(11)C]erlotinib during erlotinib therapy is unkno
PMID 26857779

Evaluation of Three Small Molecular Drugs for Targeted Therapy to Treat Nonsmall Cell Lung Cancer.

Ni J, Zhang L1.
Chinese medical journal.Chin Med J (Engl).2016 5th Feb;129(3):332-340. doi: 10.4103/0366-6999.174484.
OBJECTIVE: To guide the optimal selection among first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in clinical practice. This review attempted to provide a thorough comparison among three first-generation EGFR-TKIs, namely icotinib, erlotinib, and gefitinib, wit
PMID 26831237

The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice

Enkhtuya Radnaa,Sato Tokiharu,Wakasugi Mitsuo,Tuvshintugs Baljinnyam,Miyata Hirofumi,Sakurai Takeshi,Matsunaga Tsukasa,Yoshioka Katsuji
Genes to Cells 19(4), 350-358, 2014-04
… The ultraviolet B (UVB) component of sunlight can cause severe damage to skin cells and even induce skin cancer. … We found that UVB-induced skin epidermal apoptosis was prevented in Jlp knockout (KO) as well as in keratinocyte-specific Jlp KO mice. … Moreover, topical treatment of UVB-irradiated mouse skin with a p38 inhibitor significantly suppressed the epidermal apoptosis in wild-type mice, but not in Jlp KO mice. …
NAID 120005440448

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

Sato Hiroki,Hatanaka Kanako C.,Hatanaka Yutaka,Hatakeyama Hiromitsu,Hashimoto Ari,Matsuno Yoshihiro,Fukuda Satoshi,Sabe Hisataka
Cell Communication and Signaling 12, 17, 2014-03-12
… Background: Despite recent advances in cancer therapeutics in general, the survival of patients with head and neck squamous cell carcinomas (HNSCCs) has not improved substantially over the past few decades. … HNSCC cells often exhibit invasive and metastatic phenotypes, and expression of epidermal growth factor receptor (EGFR) and cortactin has been highly implicated in the development of malignancy in HNSCCs. …
NAID 120005438264