WordNet

of or relating to eosinophil
a tumor composed of granulation tissue resulting from injury or inflammation or infection
a leukocyte readily stained with eosin (同)eosinophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/13 21:36:14」(JST)

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Eosinophilic granuloma is a form of Langerhans cell histiocytosis. It is a condition of both human and veterinary pathology.

Feline eosinophilic granuloma complex is synonymous with feline eosinophilic skin diseases. This is considered to be a cutaneous reaction pattern that can be the manifestation of a number of underlying infections, allergies or ectoparasite infestations. It can also be idiopathic, that is have no known underlying trigger. The eosinophilic reaction is common in feline inflammatory disease and the eosinophilic granuloma can be a hereditary reaction pattern in some lines of domestic cats.

Symptoms

In cats

Cats with eosinophilic granuloma complex (EGC) may have one or more of four patterns of skin disease.

The most frequent form is eosinophilic plaque. This is a rash comprising raised red to salmon-colored and flat-topped, moist bumps scattered on the skin surface. The most common location is on the ventral abdomen and inner thigh.

Another form of EGC is the lip ulcer. This is a painless, shallow ulcer with raised and thickened edges that forms on the upper lip adjacent to the upper canine tooth. It is often found on both sides of the upper lips.

The third form of the EGC is the collagenolytic granuloma. This is a firm swelling that may be ulcerated. The lesions may form on the skin, especially of the face, in the mouth, or on the feet, or may form linear flat-topped raised hairless lesions on the back of the hind legs, also called linear granuloma.

Cat with ulcerative dermatitis of the nose caused by mosquito bite hypersensitivity

The least common form of EGC is atypical eosinophilic dermatitis. It is unique in that it is caused by mosquito bite allergy and the lesions form on the parts of the body with the least hair affording easy access to feeding mosquitoes. This includes the bridge of the nose, the outer tips of the ears and the skin around the pads of the feet. The lesions are red bumps, shallow ulcers and crusts.

In humans

In humans, eosinophilic granulomas are considered a benign histiocytosis that occurs mainly in adolescents and young adults. Clinically, unifocal lytic lesions are found in bones such as the skull, ribs and femur. Because of this, bone pain and pathologic fractures are common.^[1]

Causes

Aside from the mosquito allergy cat, cats with EGC usually have allergy, ectoparasite infestation or possibly ringworm or other skin infection. Other implicated causes include traumatic damage, autoimmune disease or FeLV infection.

Treatment

The basis of management is to find and correct the underlying cause. Many times cats with EGC will respond to treatment with corticosteroids or to cyclosporine.

References

^ Goljan, Edward F. (2011). Rapid Review Pathology. Philadelphia, PA: Elsevier. p. 246. ISBN 978-0-323-08438-3.

Medleau, Linda; Keith A Hnilica (2006). Small Animal Dermatology A Color Atlas and Therapeutic Guide. St. Louis, Missouri: Saunders Elsevier. ISBN 0-7216-2825-7. Cite uses deprecated parameters (help)
Scott, Danny W.; William H. Miller, Jr; Craig E Griffin (2001). Muller & Kirk's Small Animal Dermatology 6th Edition. Philadelphia, PA: WB Saunders Company. ISBN 0-7216-7618-9. Cite uses deprecated parameters (help)

UpToDate Contents

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1. ランゲルハンス細胞組織球症の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of langerhans cell histiocytosis
2. ランゲルハンス細胞組織球症の治療 treatment of langerhans cell histiocytosis
3. 肺ランゲルハンス細胞組織球症 pulmonary langerhans cell histiocytosis
4. 小児および思春期におけるランゲルハンス細胞組織球症（好酸球性肉芽腫）骨病変 langerhans cell histiocytosis eosinophilic granuloma of bone in children and adolescents
5. Sporadic lymphangioleiomyomatosis: Clinical presentation and diagnostic evaluation

English Journal

Surgical treatment of eosinophilic granuloma of the infratemporal fossa: A successful treatment option.

López F, Llorente JL, Suárez C.SourceDepartment of Otolaryngology and Skull Base Surgery, Hospital Universitario Central de Asturias, Oviedo, Principado de Asturias and Instituto Universitario de Oncología del Principado de Asturias , Asturias , Spain.
Acta oto-laryngologica.Acta Otolaryngol.2012 May;132(5):558-62. Epub 2012 Jan 4.
Abstract The patient was a 16-year-old girl complaining about progressive swelling on the right side of her face, right headache, and right orbital proptosis. A CT scan revealed a lytic mass centered in the greater wing of the right sphenoid bone with extension into the orbit, middle cranial fossa
PMID 22216878

A rare case of langerhans cell histiocytosis of the gastrointestinal tract.

Shankar U, Prasad M, Chaurasia OP.SourceUday Shankar, Monika Prasad, Internal Medicine, Mount Sinai School of Medicine at Queens Hospital Center, Jamaica, NY 11432, United States.
World journal of gastroenterology : WJG.World J Gastroenterol.2012 Mar 28;18(12):1410-3.
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized, bone marrow-derived langerhans cells and mature eosinophils. The clinical spectrum ranges from an acute, fulminant, disseminated disease called Letterer-Siwe disease to solitary
PMID 22493557

Japanese Journal

骨組織球症--臨床・画像上の特徴と悪性腫瘍との鑑別 (特集炎症など悪性骨・軟部腫瘍と見まちがう疾患--診断のポイント)

保坂正美,羽鳥正仁,常陸真 [他]
整形・災害外科 54(10), 1159-1170, 2011-09
NAID 40018978587

診断に難渋を要した小児大腿骨転子部骨髄炎の1例

土谷早穂,石田義博,西本昌希,池内一磨,西田佳弘
中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 53(6), 1253-1254, 2010-11-01
NAID 10027628950

Related Pictures

Eosinophilic Granuloma - Pathology - Orthobullets Orbital Eosinophilic Granuloma. EyeRounds.org - Ophthalmology - The University of Iowa EOSINOPHILIC GRANULOMA COMPLEX – FELINE | Zoetis JP Feline eosinophilic granuloma - Dermatopatologia VeterinariaDermatopatologia Veterinaria File:Langerhans-cell-histiocytosis-eosinophilic granuloma.jpg - Wikimedia Commons Eosinophilic granuloma; Granuloma, Eosinophilic Eosinophilic granuloma - Wikipedia, the free encyclopedia

★リンクテーブル★

リンク元	「ランゲルハンス細胞組織球症」「好酸球性肉芽腫症」「EG」「好酸性肉芽腫」
拡張検索	「eosinophilic granulomatosis with polyangiitis」
関連記事	「eosinophilic」

「ランゲルハンス細胞組織球症」

Eosinophilic granuloma
	Classification and external resources
	; Eosinophilic granuloma
ICD-10	D76.0 (ILDS D76.030)
ICD-9	277.89
DiseasesDB	5906
MeSH	D004803

　　[★]

英: Langerhans-cell histiocytosis LCH, Langerhans cell histiocytosis
同: ランゲルハンス細胞性組織球症、Langerhans細胞組織球症 Langerhans細胞性組織球症、組織球症X histiocytosis X、骨組織球症X histiocytosis X of bone、クラスI組織球症候群 histiocytosis syndrome class I
関: レッテラー・シーベ病

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