enzyme reactivator

WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase.

Atanasov VN, Petrova I, Dishovsky C.SourceDepartment of Disaster Medicine and Toxicology, Military Medical Academy, 3, St.G. Sofiiski Str., 1606 Sofia, Bulgaria; Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 J. Bourchier Ave., 1164 Sofia, Bulgaria. Electronic address: vatanasov@chem.uni-sofia.bg.
Chemico-biological interactions.Chem Biol Interact.2013 Mar 25;203(1):139-43. doi: 10.1016/j.cbi.2012.11.020. Epub 2012 Dec 7.
Organophosphorus compounds (OPC) were developed as warfare nerve agents. They are also widely used as pesticides. The drug therapy of intoxication with OPC includes mainly combination of cholinesterase (ChE) reactivators and cholinolytics. There is no single ChE reactivator having an ability to reac
PMID 23220589

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.SourceSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA. zradic@ucsd.edu
The Biochemical journal.Biochem J.2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.
In the present paper we show a comprehensive in vitro, ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non-pyridinium oxime reactivators. We identified TAB2O
PMID 23216060

The history of cholinesterase reactivation: hydroxylamine and pyridinium aldoximes.

Petroianu GA.SourceHerbert Wertheim College of Medicine, Florida International University, Department of Cellular Biology & Pharmacology, University Park (11200 SW 8th Street), Miami, 33199 FL, USA. georg.petroianu@fiu.edu
Die Pharmazie.Pharmazie.2012 Oct;67(10):874-9.
Hydroxylamine (NH2OH) the substance which will turn out to be of importance to those interested in the treatment of organophosporus cholinesterase inhibitor exposure, was synthesized by Wilhem Clemens Lossen in 1865 while working in Halle as an assistant in the laboratory of Wilhelm Heinrich Heintz.
PMID 23136724