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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/16 20:49:27」(JST)

English Journal

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

Akbergenov R1, Shcherbakov D, Matt T, Duscha S, Meyer M, Wilson DN, Böttger EC.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2011 Oct;55(10):4712-7. doi: 10.1128/AAC.00628-11. Epub 2011 Jul 18.
Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix
PMID 21768509

When do adaptive plasticity and genetic evolution prevent extinction of a density-regulated population?

Chevin LM1, Lande R.
Evolution; international journal of organic evolution.Evolution.2010 Apr 1;64(4):1143-50. doi: 10.1111/j.1558-5646.2009.00875.x. Epub 2009 Oct 23.
We study the dynamics of evolutionary recovery after an abrupt environmental shift in a density-regulated population with evolving plasticity. Maladaptation to the new environment initially causes the population to decline, until adaptive phenotypic plasticity and genetic evolution restore positive
PMID 19863583

[Case of multi-drug resistant pulmonary tuberculosis with bilateral cavitary lesions successfully treated by surgical treatment].

Okumura M1, Ogata H, Yoshiyama T, Kokutoh H, Tadokoro E, Kubota M, Ueyama M, Wada M, Nakajima Y.
Kekkaku : [Tuberculosis].Kekkaku.2007 Nov;82(11):831-5.
A case was 38 years old male. He was pointed out abnormal shadow on chest X-ray and complained respiratory infection symptoms. He had not past history of tuberculosis. He was diagnosed as multi-drug resistant tuberculosis (MDR-TB) in a certain hospital and was referred to our hospital to undergo tre
PMID 18078108

奥村昌夫,尾形英雄,吉山崇,国東博之,田所衛司,窪田素子,上山雅子,和田雅子,中島由槻
結核 82(11), 831-835, 2007-11-15
… His drug sensitivity test by Ogawa medium was resistant to all anti-tuberculosis drugs except for kanamycin (KM) and enviomycin (EVM). …
NAID 10025687914

小山和彦,川上健司,原田義高,山領豪,木村由美子
結核 82(7), 577-581, 2007-07-15
… As the drug susceptibility test revealed that the isolated strain was multi-drug resistant, the regimen was changed to pyrazinamide, ethionamide, cycloserine, enviomycin, and levofloxacin. …
NAID 10019827586

野上達也,関矢信康,三潴忠道,山口哲生
結核 81(8), 525-529, 2006-08-15
… He had been suffering from these symptoms since 1982, though the intensive anti-mycobacterial chemotherapy such as three-drug (RFP, SM, &INH), twice two-drug (KM & SM and cycloserine & enviomycin) and four-drug (CAM, EB, RFP, & KM) regimens were administered for 26 months from July 1999. …
NAID 10018335686

リンク元	「エンビオマイシン」
拡張検索	「enviomycin sulfate」

Enviomycin
Systematic (IUPAC) name
	3,6-diamino-N-[(3R,6Z)-3-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]-4-hydroxyhexanamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	IM
Identifiers
CAS number	33103-22-9
ATC code	None
PubChem	CID 3032903
ChemSpider	16736480
UNII	XU299C23A2
KEGG	D07897
Chemical data
Formula	C25H43N13O10
Mol. mass	685.69 g/mol
	SMILES C1CN=C(NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CO)CO)NC;
	InChI InChI=1S/C25H43N13O10/c26-3-1-16(41)10(27)5-17(42)33-12-6-31-23(47)18(11-2-4-30-24(28)37-11)38-20(44)13(7-32-25(29)48)34-21(45)14(8-39)36-22(46)15(9-40)35-19(12)43/h7,10-12,14-16,18,39-41H,1-6,8-9,26-27H2,(H,31,47)(H,33,42)(H,34,45)(H,35,43)(H,36,46)(H,38,44)(H3,28,30,37)(H3,29,32,48)/b13-7-/t10-,11-,12+,14+,15+,16-,18+/m1/s1; Key:HPWIIERXAFODPP-GHBBWTPBSA-N ;
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