enkephalinamide

English Journal

The influence of the new enkephalin derivative, cyclo[N(ε),N(β)-carbonyl-d-Lys(2),Dap(5)] enkephalinamide (cUENK6), on reinstatement of ethanol-induced conditioned place preference in rats.

Gibula-Bruzda E1, Marszalek-Grabska M2, Gawel K2, Witkowska E3, Izdebski J3, Kotlinska JH2.
Physiology & behavior.Physiol Behav.2015 Jun 1;145:50-6. doi: 10.1016/j.physbeh.2015.03.031. Epub 2015 Mar 26.
The aim of the present study was to determine whether a new cyclic analog of enkephalin, cyclo[N(ε),N(β)-carbonyl-d-Lys(2),Dap(5)] enkephalinamide (cUENK6), a preferential μ-(MORs), and, to a lower extent, a δ-opioid receptor (DORs) agonist in vitro, could reinstate ethanol-induced conditioned p
PMID 25817357

Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.

Gibula-Bruzda E1, Marszalek-Grabska M2, Witkowska E3, Izdebski J3, Kotlinska JH2.
Alcohol (Fayetteville, N.Y.).Alcohol.2015 May;49(3):229-36. doi: 10.1016/j.alcohol.2015.01.007. Epub 2015 Feb 3.
An analog of enkephalin, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), is predominantly a functional agonist of μ-opioid receptors (MOPr) and, to a lesser extent, of δ-opioid receptors (DOPr) in vitro. The aim of the present study was to determine whether cUENK6 could affec
PMID 25716198

Hypothalamic peptides controlling alcohol intake: differential effects on microstructure of drinking bouts.

Chen YW1, Barson JR2, Chen A3, Hoebel BG3, Leibowitz SF4.
Alcohol (Fayetteville, N.Y.).Alcohol.2014 Nov;48(7):657-64. doi: 10.1016/j.alcohol.2014.08.005. Epub 2014 Aug 20.
Different alcohol drinking patterns, involving either small and frequent drinking bouts or large and long-lasting bouts, are found to differentially affect the risk for developing alcohol-related diseases, suggesting that they have different underlying mechanisms. Such mechanisms may involve orexige
PMID 25241055

Effects of Peptidase Inhibitors, jp-Ala2, Met5]-Enkephalinamide and Antiserum to Methionine-Enkephalin Microinjected Into the Caudal Periaqueductal Gray on Morphine Withdrawal in Rats

Fukunaga Yuko,Inoue Norihiro,Miymoto Masahiko [他],KISHIOKA Shiroh,YAMAMOTO Hiroyuki
The Japanese journal of pharmacology 78(4), 455-461, 1998-12-01
… However, [D-Ala<SUP>2</SUP>, Met<SUP>5</SUP>]-enkephalinamide (20 nmol), an enkephalin analog, injected into the cPAG decreased the number of jumping without any influence on the other withdrawal signs. …
NAID 10008681746

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection : II. Application to ocular permeability studies in vitro

RANTA Veli-Pekka,HAMALAINEN Kaisa Mari,AURIOLA Seppo,URTTI Arto
Journal of chromatography. B, Biomedical sciences and applications 709(1), 1-10, 1998-05-08
NAID 10024528122