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delicate connective tissue around individual nerve fibers in nerve

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 20:41:34」(JST)

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The endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or Henle's sheath) is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber. Its component cells are called endoneurial cells.^[1] The endoneuria with their enclosed nerve fibers are bundled into groups called nerve fascicles, each fascicle within its own protective sheath called a perineurium. In sufficiently large nerves multiple fascicles, each with its blood supply and fatty tissue, may be bundled within yet another sheath, the epineurium.

The endoneurium contains a liquid known as endoneurial fluid, which contains little protein. In the peripheral nervous system the endoneurial fluid is notionally equivalent to cerebro-spinal fluid in the central nervous system. Peripheral nerve injuries commonly release increased amounts of endoneurial fluid into surrounding tissues; these can be detected by magnetic resonance neurography, thereby assisting in locating injuries to peripheral nerves.

The endoneurium runs longitudinally along the nerve fiber, but with discontinuities where septa pass inward from the innermost layer of the perineurium. It contains fine bundles of fibrous connective tissue, primarily collagen, embedded in a matrix of ground substance. This structure serves to support capillary blood vessels, arranged so as to form a network of elongated meshes. Similar structures occur around some nervous components elsewhere in the body, for example around the Schwann cells on the peripheral side of the transitional zone on the auditory nerve.^[2]

References

^ Elaine N. Marieb and Katja Hoehn (2007). Human Anatomy & Physiology (7th Ed.). Pearson. pp. 498–9. ISBN 0-8053-5909-5.
^ Fraher JP (2000). "The transitional zone and CNS regeneration". J. Anat. 196 (1): 137–58. PMID 10697296.

External links

Histology image: 21301loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: myelinated axon and Schwann cell"
Histology image: 21401loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: arteriole and peripheral nerve"
Histology image: 1_03 at the University of Oklahoma Health Sciences Center
Histology at University of California, Los Angeles
Diagram at Howard University

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English Journal

Expression of neutrophil gelatinase-associated lipocalin (NGAL) in peripheral nerve repair.

Aghanasir F1, Aghaei H2, Imani Fooladi AA3, Ebrahimi M4, Bagherpour G5, Nourani MR6,7.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Aug;36(4):429-34. doi: 10.3109/10799893.2015.1132238. Epub 2016 Apr 17.
INTRODUCTION: Trauma is one of the causes of peripheral nerve injuries. Free radicals increase after tissue damage. Free radicals are usually scavenged and detoxiﬁed by antioxidants. In this study, we assessed the antioxidative role of the NGAL molecule in sciatic nerve repair in rats.MATERIALS AN
PMID 27087673

Advances in peripheral nervous system regenerative therapeutic strategies: A biomaterials approach.

Dalamagkas K1, Tsintou M1, Seifalian A2.
Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2016 Aug 1;65:425-32. doi: 10.1016/j.msec.2016.04.048. Epub 2016 Apr 16.
Peripheral nerve injury is a very common medical condition with varying clinical severity but always great impact on the patients' productivity and the quality of life. Even the current 1st-choice surgical therapeutic approach or the "gold standard" as frequently called in clinical practice, is not
PMID 27157770

Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-α6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.

Vijay S1, Chiu M2, Dacks JB2, Roberts RC3.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Jul;1862(7):1279-90. doi: 10.1016/j.bbadis.2016.04.003. Epub 2016 Apr 9.
Charcot-Marie-Tooth disease type 4C (CMT4C) is one of the commonest autosomal recessive inherited peripheral neuropathies and is associated with mutations in the Rab11 effector, SH3TC2. Disruption of the SH3TC2-Rab11 interaction is the molecular abnormality underlying this disease. However, why SH3T
PMID 27068304

Japanese Journal

頬粘膜に発生した神経鞘粘液腫の1例

愛甲勝哉,山口聰,道泰之,黒原一人,石川均,天笠光雄
日本口腔外科学会雑誌 54(4), 281-285, 2008-04-20
… Nerve sheath myxoma is a benign tumor originating from the endoneurium. …
NAID 10027088557

神経向性悪性黒色腫の2例

神野千鶴,黒川正人,諸岡久香,中西新,行岡直哉
Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 22(3), 277-281, 2008-03-25
… Neurotropic melanoma is a rare tumor which invades and extends along nerves, either in the penneural space or in the endoneurium. …
NAID 10022601461

ラット下歯槽神経における神経因性疼痛に関する神経病理組織学的研究

吉田充広
九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 57(1・2), 14-24, 2003-04-25
… 2) Chronic IAN compression caused destruction of endoneurium and myelin sheath in the IAN. …
NAID 110003001718

Related Pictures

★リンクテーブル★

リンク元	「endoneurial」「神経内膜」

「endoneurial」

Endoneurium
	Transverse section of human tibial nerve.
	Nerve structure
Identifiers
Gray's	p.728
MeSH	A08.800.800
Dorlands; /Elsevier	e_09/12332510
TA	A14.2.00.014
FMA	52586
	Anatomical terminology