エンカイニド
WordNet
- antiarrhythmic drug (trade name Enkaid) used to treat life-threatening arrhythmias but increases the risk of sudden death in heart attack patients (同)Enkaid
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/14 15:51:50」(JST)
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Encainide
|
Systematic (IUPAC) name |
4-methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide |
Clinical data |
Trade names |
Enkaid |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
MedlinePlus |
a605040 |
Legal status |
Withdrawn |
Identifiers |
CAS number |
66778-36-7 |
ATC code |
C01BC08 |
PubChem |
CID 48041 |
DrugBank |
DB01228 |
ChemSpider |
43697 Y |
UNII |
SY3J0147NB Y |
KEGG |
D07894 Y |
ChEBI |
CHEBI:4788 Y |
ChEMBL |
CHEMBL315838 |
Chemical data |
Formula |
C22H28N2O2 |
Mol. mass |
352.47 g/mol |
SMILES
- CC(CN1CCCCC1)c3ccccc3NC(=O)c2ccc(OC)cc2
|
InChI
-
InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25) Y
Key:PJWPNDMDCLXCOM-UHFFFAOYSA-N Y
|
Y (what is this?) (verify) |
Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.[1]
See also
- Cardiac Arrhythmia Suppression Trial
References
- ^ Echt, D. S.; Liebson, P. R.; Mitchell, L. B.; Peters, R. W.; Obias-Manno, D.; Barker, A. H.; Arensberg, D.; Baker, A.; Friedman, L.; Greene, H. L.; Huther, M. L.; Richardson, D. W. (1991). "Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo". New England Journal of Medicine 324 (12): 781–788. doi:10.1056/NEJM199103213241201. PMID 1900101. edit
Channel blockers
|
|
Calcium (Ca2+) |
|
|
Potassium (K+) |
- 3,4-Diaminopyridine
- 4-Aminopyridine
- Amiodarone
- Bretylium
- Bunaftine
- Charybdotoxin
- Conotoxins
- Dofetilide
- Dronedarone
- E-4031
- Ibutilide
- Linopirdine
- Maurotoxin
- Nifekalant
- Paxilline
- Sotalol
- Tedisamil
- Tetraethylammonium
- Vernakalant
|
|
Sodium (Na+) |
- Antiarrhythmics: Ajmaline
- Aprindine
- Disopyramide
- Dronedarone
- Encainide
- Flecainide
- Lidocaine
- Lorajmine
- Lorcainide
- Mexiletine
- Moricizine
- Phenytoin
- Pilsicainide
- Prajmaline
- Procainamide
- Propafenone
- Quinidine
- Sparteine
- Tocainide
- Anticonvulsants: Carbamazepine
- Eslicarbazepine acetate
- Ethotoin
- Fosphenytoin
- Licarbazepine
- Mephenytoin
- Oxcarbazepine
- Oxitriptyline
- Phenytoin
- Rufinamide
- Topiramate
- Sodium valproate
- Valnoctamide
- Valproate pivoxil
- Valproate semisodium
- Valproic acid
- Valpromide
- Diuretics: Amiloride
- Benzamil
- Triamterene
- Local anesthetics: pFBT
- Amylocaine
- Articaine
- Benzocaine
- Bupivacaine (Levobupivacaine, Ropivacaine)
- Butacaine
- Butamben
- Chloroprocaine
- Cinchocaine
- Cocaine
- Cyclomethycaine
- Dimethocaine
- Diphenhydramine
- Etidocaine
- Hexylcaine
- Iontocaine
- Lidocaine
- Mepivacaine
- Meprylcaine
- Metabutoxycaine
- Orthocaine
- Piperocaine
- Prilocaine
- Procaine
- Propoxycaine
- Proxymetacaine
- Risocaine
- Tetracaine
- Trimecaine
- Toxins: Conotoxins
- Neosaxitoxin
- Saxitoxin
- Tetrodotoxin
|
|
Other |
- Uncategorized: Ethadione
- Paramethadione
- Phenacemide
- Pheneturide
- Trimethadione
|
|
Antiarrhythmic agents (C01B)
|
|
Channel blockers |
class I
(Na+ channel blockers)
|
class Ia (Phase 0→ and Phase 3→)
|
- Ajmaline
- Disopyramide
- Lorajmine
- Prajmaline
- Procainamide#
- Quinidine#
- Sparteine
|
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class Ib (Phase 3←)
|
- IV (Lidocaine#)
- enteral (Aprindine
- Mexiletine
- Tocainide)
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class Ic (Phase 0→)
|
- Encainide‡
- Ethacizine
- Flecainide
- Indecainide‡
- Lorcainide
- Moracizine‡
- Propafenone
|
|
|
class III
(Phase 3→, K+ channel blockers)
|
- Amiodarone
- Bretylium
- Bunaftine
- Dofetilide
- Dronedarone
- E-4031†
- Ibutilide
- Nifekalant
- Sotalol
- Tedisamil
- Vernakalant
|
|
class IV
(Phase 4→, Ca2+ channel blockers)
|
|
|
|
Receptor agonists
and antagonists |
class II
(Phase 4→, β blockers)
|
- Nadolol
- Pindolol
- Propranolol
- cardioselective (Acebutolol
- Atenolol
- Esmolol
- Metoprolol)
|
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A1 agonist
|
- Adenosine
- Benzodiazepines
- Barbiturates
|
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M2
|
- muscarinic antagonist: Atropine
- Disopyramide
- Quinidine
muscarinic agonist: Digoxin
|
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α receptors
|
- Amiodarone
- Bretylium
- Quinidine
- Verapamil
|
|
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Ion transporters |
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco/cong/tumr, sysi/epon, injr
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proc, drug (C1A/1B/1C/1D), blte
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UpToDate Contents
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English Journal
- Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.
- Galimberti ES, Knollmann BC.SourceDivision of Clinical Pharmacology and Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, USA.
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2011 Nov;51(5):760-8. Epub 2011 Jul 12.
- Ca(2+) waves can trigger ventricular arrhythmias such as catecholaminergic-polymorphic ventricular tachycardia (CPVT). Drugs that prevent Ca(2+) waves may have antiarrhythmic properties. Here, we use permeabilized ventricular myocytes from a CPVT mouse model lacking calsequestrin (casq2) to screen a
- PMID 21798265
- [When and how to treat ventricular ectopic beats].
- D'Este D, Sorbo MD.SourceU.O.C. di Cardiologia, Ospedale di Dolo (VE). daniele.deste@ulss13mirano.ven.it
- Giornale italiano di cardiologia (2006).G Ital Cardiol (Rome).2010 Oct;11(10 Suppl 1):21S-26S.
- Ventricular ectopic beats are commonly observed in daily clinical practice, either in symptomatic or asymptomatic subjects. In many subjects these arrhythmias are casually detected during a screening visit. Their occurrence is usually associated with no clinical significance. However, in some cases
- PMID 21416822
Japanese Journal
- Mortality following ventricular arrhythmia suppression by Encainide, Flecainide and Moricizine after myocardial infarction
- Increased risk of death and cardiac arrest from encainide and flecainide in patients after non-Q-wave acute myocardial infarction in the Cardiac Arrhythmia Suppression Trial
- Mortality in patients treaated with flecainide and encainide for supraventricular arrhythmias
Related Links
- encainide /en·cai·nide/ (en-ka´nīd) a sodium channel blocker that acts on the Purkinje fibers and myocardium; used as the hydrochloride salt in treatment of life-threatening arrhythmias. encainide [en-ka´nīd] a sodium channel blocking agent ...
- Encainide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Added to Favorites Dictionary Thesaurus Word Dynamo Quotes Reference Translator Spanish Log In ...
Related Pictures
★リンクテーブル★
[★]
- 同
- cardiac arrhythmia supression trial
- 関
- 抗不整脈薬
- 抗不整脈薬の役割を明確にするため施行させた大規模臨床試験
- 心筋梗塞後の心室期外収縮をIc群のencainide、 flecainideで抑制したところかえって突然死が増加した
- →抗不整脈薬の催不整脈作用に対する薬物治療のあり方に変化