エレドイシン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/05/08 13:14:29」(JST)
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Eledoisin |
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IUPAC name
(3S)-3-[[(2S)-6-amino-2-[[(2S)-3-hydroxy-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
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Identifiers |
PubChem |
10328936 |
ChemSpider |
6006 |
ChEMBL |
CHEMBL373569 |
Jmol-3D images |
Image 1 |
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O=C(NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N)CCSC)CC(C)C)C(C)CC)Cc1ccccc1)C)CC(=O)O)CCCCN)CO)C3N(C(=O)C2NC(=O)CC2)CCC3
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InChI=1/C54H85N13O15S/c1-7-30(4)44(53(81)57-27-42(70)60-36(24-29(2)3)49(77)61-33(45(56)73)20-23-83-6)66-50(78)37(25-32-14-9-8-10-15-32)63-46(74)31(5)58-48(76)38(26-43(71)72)64-47(75)34(16-11-12-21-55)62-51(79)39(28-68)65-52(80)40-17-13-22-67(40)54(82)35-18-19-41(69)59-35/h8-10,14-15,29-31,33-40,44,68H,7,11-13,16-28,55H2,1-6H3,(H2,56,73)(H,57,81)(H,58,76)(H,59,69)(H,60,70)(H,61,77)(H,62,79)(H,63,74)(H,64,75)(H,65,80)(H,66,78)(H,71,72)
Key: AYLPVIWBPZMVSH-UHFFFAOYAZ
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Properties |
Molecular formula |
C54H85N13O15S |
Molar mass |
1188.40 g/mol |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.
It was first isolated from the posterior salivary glands of two mollusk species Eledone muschata and Eledone aldovandi, which belong to the octopod order of Cephalopoda. [1]
Other tachykinins from nonmammalian sources include kassinin and physalaemin. The mammalian tachykinins substance P, NKA, and NKB have similar effects as tachykinins of nonmammals and have been more widely studied and characterized. These peptides exhibit a wide and complex spectrum of pharmacological and physiological activities such as vasodilation, hypertension, and stimulation of extravascular smooth muscle.[2]
Eledoisin has the amino acid sequence pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH. Like all tachykinin peptides, Eledoisin shares the same consensus C-terminal sequence, that is, Phe-Xxx-Gly-Leu-Met-NH. The invariant "Phe7" residue is probably required for receptor binding. "Xxx" is either an aromatic (phenylalanine, tyrosine) or a branched aliphatic (valine, isoleucine) side chain and is thought to be important in receptor selectivity. This common region, often referred to as the "message domain," is believed to be responsible for activating the receptor. The divergent N-terminal region or the "address domain" varies in amino-acid sequence and length and is believed to play a role in determining the receptor subtype specificity. [3]
References
- ^ De Marco, A., and G. Gatti, "1H- and 13C-NMR spectra of eledoisin and intermediate oligopeptides." Int. J. Pep. Pro. Res. 7:437–444, 1975.
- ^ R. Christy Rani Grace, Indu R. Chandrashekar and Sudha M. Cowsik, "Solution Structure of the Tachykinin Peptide Eledoisin", Biophysical Journal 84:655-664 (2003), retrieved 05 Dec 2007. This publication has excellent general information on the eledoisin molecule.
- ^ Schwyzer, R., "Membrane-assisted molecular mechanism of neurokinin receptor subtype selection." EMBO J. 6:2255–2259, 1987
Neuropeptidergics
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Cholecystokinin |
CCKA
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- Agonists: Cholecystokinin
- CCK-4
Antagonists: Asperlicin
- Proglumide
- Lorglumide
- Devazepide
- Dexloxiglumide
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CCKB
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- Agonists: Cholecystokinin
- CCK-4
- Gastrin
Antagonists: Proglumide
- CI-988
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CRH |
CRF1
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- Agonists: Corticotropin releasing hormone
Antagonists: Antalarmin
- CP-154,526
- Pexacerfont
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CRF2
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- Agonists: Corticotropin releasing hormone
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Galanin |
GAL1
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- Agonists: Galanin
- Galanin-like peptide
- Galmic
- Galnon
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GAL2
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- Agonists: Galanin
- Galanin-like peptide
- Galmic
- Galnon
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GAL3
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- Agonists: Galanin
- Galmic
- Galnon
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Ghrelin |
- Agonists: Ghrelin
- Capromorelin
- MK-677
- Sermorelin
- SM-130,686
- Tabimorelin
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GnRH |
- Agonists: Buserelin
- Deslorelin
- GnRH
- Goserelin
- Histrelin
- Leuprorelin
- Nafarelin
- Triptorelin
Antagonists: Abarelix
- Cetrorelix
- Degarelix
- Ganirelix
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MCH |
MCH1
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- Agonists: Melanin concentrating hormone
Antagonists: ATC-0175
- GW-803,430
- NGD-4715
- SNAP-7941
- SNAP-94847
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MCH2
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- Agonists: Melanin concentrating hormone
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Melanocortin |
MC1
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- Agonists: alpha-MSH
- Afamelanotide
- BMS-470,539
- Bremelanotide
- Melanotan II
Antagonists: Agouti signalling peptide
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MC2
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- Agonists: ACTH
- Cosyntropin
- Tetracosactide
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MC3
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- Agonists: alpha-MSH
- Bremelanotide
- Melanotan II
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MC4
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- Agonists: alpha-MSH
- Bremelanotide
- Melanotan II
- PF-00446687
- THIQ
Antagonists: Agouti-related peptide
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MC5
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- Agonists: alpha-MSH
- Melanotan II
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Neuropeptide S |
- Agonists: Neuropeptide S
Antagonists: SHA-68
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Neuropeptide Y |
Y1
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- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: BIBP-3226
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Y2
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- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: BIIE-0246
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Y4
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- Agonists: Neuropeptide Y
- Pancreatic polypeptide
- Peptide YY
Antagonists: UR-AK49
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Y5
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- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: Lu AA-33810
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Neurotensin |
NTS1
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- Agonists: Neurotensin
- Neuromedin N
Antagonists: SR-48692
- SR-142,948
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NTS2
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- Agonists: Neurotensin
Antagonists: Levocabastine
- SR-142,948
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Orexin |
OX1
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- Agonists: Orexin-A
Antagonists: Almorexant
- SB-334,867
- SB-408,124
- SB-649,868
- Suvorexant
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OX2
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- Agonists: Orexin-A
Antagonists: Almorexant
- SB-649,868
- Suvorexant
- TCS-OX2-29
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Oxytocin |
- Agonists: Carbetocin
- Demoxytocin
- Oxytocin
- WAY-267,464
Antagonists: Atosiban
- Epelsiban
- L-371,257
- L-368,899
- Retosiban
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Tachykinin |
NK1
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- Agonists: Substance P
Antagonists: Aprepitant
- Befetupitant
- Casopitant
- CI-1021
- CP-96,345
- CP-99,994
- CP-122,721
- Dapitant
- Ezlopitant
- FK-888
- Fosaprepitant
- GR-203,040
- GW-597,599
- HSP-117
- L-733,060
- L-741,671
- L-743,310
- L-758,298
- Lanepitant
- LY-306,740
- Maropitant
- Netupitant
- NKP-608
- Nolpitantium
- Orvepitant
- RP-67,580
- SDZ NKT 343
- Vestipitant
- Vofopitant
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NK2
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- Agonists: Neurokinin A
Antagonists: GR-159,897
- Ibodutant
- Saredutant
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NK3
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- Agonists: Neurokinin B
Antagonists: Osanetant
- Talnetant
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Vasopressin |
V1A
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- Agonists: Desmopressin
- Felypressin
- Ornipressin
- Terlipressin
- Vasopressin
Antagonists: Conivaptan
- Demeclocycline
- Relcovaptan
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V1B
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- Agonists: Felypressin
- Ornipressin
- Terlipressin
- Vasopressin
Antagonists: Demeclocycline
- Nelivaptan
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V2
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- Agonists: Desmopressin
- Ornipressin
- Vasopressin
Antagonists: Conivaptan
- Demeclocycline
- Lixivaptan
- Mozavaptan
- Satavaptan
- Tolvaptan
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Peptides: neuropeptides
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Hormones |
see hormones
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Opioid peptides |
Dynorphin
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Big dynorphin • Dynorphin A • Dynorphin B
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Endorphin
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Beta-endorphin • Alpha-endorphin • Gamma-endorphin • α-neo-endorphin • β-neo-endorphin
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Enkephalin
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Met-enkephalin • Leu-enkephalin
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Others
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Adrenorphin • Amidorphin · Leumorphin · Nociceptin · Opiorphin • Spinorphin
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Other neuropeptides |
Kinins
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Bradykinin
Tachykinins: mammal (Substance P, Neurokinin A, Neurokinin B) · amphibian (Kassinin, Physalaemin)
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Neuromedins
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B · N · S · U
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Other
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Angiotensin · Bombesin · Calcitonin gene-related peptide · Carnosine · Cocaine and amphetamine regulated transcript · Delta sleep-inducing peptide · FMRFamide · Galanin · Galanin-like peptide · Gastrin releasing peptide · Neuropeptide S · Neuropeptide Y · Neurophysins · Neurotensin · Pancreatic polypeptide · Pituitary adenylate cyclase activating peptide · RVD-Hpα · VGF
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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English Journal
- Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study.
- Nebbioso M1, Evangelista M, Librando A, Plateroti AM, Pescosolido N.
- Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.Biomed Pharmacother.2013 Sep;67(7):659-63. doi: 10.1016/j.biopha.2013.07.001. Epub 2013 Jul 12.
- BACKGROUND: To evaluate the effects of an eye drop containing eledoisin and carnitine in patients suffering from primary open-angle glaucoma (POAG) and ocular discomfort syndrome secondary to a chronically treated with eye drops containing benzalkonium chloride (BAK) as preservative. The dry eye dis
- PMID 23906760
- 6-Benzylaminopurine alleviates chilling injury of postharvest cucumber fruit through modulating antioxidant system and energy status.
- Chen B1, Yang H.
- Journal of the science of food and agriculture.J Sci Food Agric.2013 Jun;93(8):1915-21. doi: 10.1002/jsfa.5990. Epub 2012 Dec 19.
- BACKGROUND: 6-Benzylaminopurine (6-BA) has a close relationship with the stress resistance of plants. Little research has been carried out on the effects of 6-BA on the cold resistance of postharvest fruits and vegetables. Therefore the aim of the present study was to evaluate the effects of 6-BA on
- PMID 23258766
- Structural heterogeneity of doubly-charged peptide b-ions.
- Li X1, Huang Y, O'Connor PB, Lin C.
- Journal of the American Society for Mass Spectrometry.J Am Soc Mass Spectrom.2011 Feb;22(2):245-54. doi: 10.1007/s13361-010-0036-1. Epub 2011 Jan 29.
- Performing collisionally activated dissociation (CAD) and electron capture dissociation (ECD) in tandem has shown great promise in providing comprehensive sequence information that was otherwise unobtainable by using either fragmentation method alone or in duet. However, the general applicability of
- PMID 21472584
Japanese Journal
- 培養ラット胎児脊髄腹側神経細胞に対する Tachykinin 系ペプチドの突起伸展促進効果
- 東邦醫學會雜誌 = Journal of the Medical Society of Toho University 45(2), 219-226, 1998-03-01
- NAID 10012221797
- Assays of 125I-Bolton-Hunter Substance P Binding Sites, Functional Sites of Tachykinin NK1 Receptor : Quantitative Receptor Autoradiographic Method
- 離乳時および組織学的成熟化開始時のラット顎下腺の分泌応答
Related Links
- eledoisinとは。意味や和訳。[名詞] 〔薬学〕 エレドイシン C54H85N13O15S:ジャコウダコなど Eledone 属のタコの唾液腺だえきせんから採れるペプチド;血管拡張,血管外平滑筋収縮作用がある.[語源]1965 - 80万項目以上収録、例文 ...
- Eledoisinとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Eledoisinとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ 本文へ ...
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