ecthyma gangrenosum

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/16 14:48:52」(JST)

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Ecthyma gangrenosum
Classification and external resources
DiseasesDB	29391
eMedicine	derm/539

Ecthyma gangrenosum is an infection of the skin typically caused by Pseudomonas aeruginosa. It is often seen in immunocompromised patients such as those with neutropenia. Ecthyma gangrenosum presents as a round or oval lesion, 1 cm to 15 cm in diameter, with a halo of erythema. A necrotic center is usually present with a surrounding erythematous edge, representing where the organism invaded blood vessels and caused infarctions. These ulcerative lesions are single or multiple and heal with scar formation, although sepsis resulting from other gram negative bacteria can also cause this condition.

Pathophysiology

The lesion is caused by perivascular invasion of bacteria in the dermis and subcutaneous tissue. The mechanism of tissue destruction is Pseudomonas exotoxin A, a toxin similar to Corynebacterium diphtheriae toxin that inactivates elongation factor 2 (thus inhibiting protein synthesis), elastase (an enzyme which degrades elastin in the blood vessel walls), phospholipase C (which degrades phospholipids in cell membranes), and pyocyanin (which generates reactive oxygen species).

See also

• Ecthyma
• List of cutaneous conditions

UpToDate Contents

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• 1. 皮膚、軟部組織、および骨の緑膿菌感染 pseudomonas aeruginosa skin soft tissue and bone infections
• 2. 非HIV免疫不全ホストにおける高熱および発疹の感染性原因 infectious causes of fever and rash in non hiv immunocompromised hosts
• 3. 水曝露後の軟部組織感染 soft tissue infections following water exposure
• 4. 膿痂疹 impetigo
• 5. HIV感染患者における発熱および発疹 fever and rash in hiv infected patients

English Journal

• Labial ecthyma gangrenosum in an immunocompromised infant with leukemia: heightening awareness for the urologist.

• Pulido J, McMahon P, Treat JR, Gunselman J, Tasian GE, Tasian SK.SourcePerelman School of Medicine, the University of Pennsylvania, Pennsylvania.
• Urology.Urology.2012 Dec;80(6):1366-8. doi: 10.1016/j.urology.2012.08.020. Epub 2012 Oct 2.
• Ecthyma gangrenosum (EG) is a cutaneous infection most commonly associated with Pseudomonas aeruginosa sepsis. EG generally occurs in immunocompromised hosts, such as patients with severe neutropenia. EG presents as erythematous, hemorrhagic, or necrotic macules or plaques, most commonly in the peri
• PMID 23040328

Japanese Journal

• Ecthyma on the Forehead: Rare Condition in the Community Setting

• Nonaka Yuko,Yoshinaga Takayuki,Iwata Kentaro
• Internal Medicine 50(21), 2705-2705, 2011
• NAID 130001288648

• Localized ecthyma gangrenosum in patients with diabetes mellitus : Diagnosis and management

• KIM Hei Sung,LEE Joyce S. S.,TANG Mark B. Y.
• Journal of dermatology 37(8), 758-761, 2010-08-01
• NAID 10027067089

Related Links

• Ecthyma Gangrenosum - E-Medicine - Medscape

23 Nov 2011 ... Ecthyma gangrenosum (EG) is a well-recognized but uncommon cutaneous infection most often associated with a Pseudomonas aeruginosa bacteremia. EG usually occurs in patients who are critically ill and ...

• Ecthyma gangrenosum - Wikipedia, the free encyclopedia

Ecthyma gangrenosum is an infection of the skin typically caused by Pseudomonas aeruginosa. It's often seen in immunocompromised patients.It presents as a round or oval lesion, 1 cm to 15 cm in diameter, with a halo of erythema. A necrotic ...

Related Pictures

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★リンクテーブル★

リンク元	「悪液質性壊疽性膿瘡」

「悪液質性壊疽性膿瘡」

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英

cachectic gangrenous ecthyma

ラ

ecthyma cachecticorum, ecthyma gangrenosum

関

壊疽性膿瘡