WordNet

(of exocrine glands) producing a clear aqueous secretion without releasing part of the secreting cell; important in regulating body temperature

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1. 好中球性皮膚症 neutrophilic dermatoses
2. 従来の癌の化学療法による皮膚合併症 cutaneous complications of conventional chemotherapy agents
3. 皮膚付属器癌 cutaneous adnexal tumors
4. 妊娠中の肌、髪、爪、粘膜 the skin hair nails and mucous membranes during pregnancy
5. 全身化学療法に対する輸注反応 infusion reactions to systemic chemotherapy

The second report of a new hypomyelinating disease due to a defect in the VPS11 gene discloses a massive lysosomal involvement.

Hörtnagel K1,2, Krägeloh-Mann I3, Bornemann A4, Döcker M1, Biskup S1,2,5, Mayrhofer H3, Battke F2, du Bois G6, Harzer K7.
Journal of inherited metabolic disease.J Inherit Metab Dis.2016 Nov;39(6):849-857. Epub 2016 Jul 29.
Vesicular protein sorting-associated proteins (VPS, including VPS11) are indispensable in the endocytic network, in particular the endosome-lysosome biogenesis. Exome sequencing revealed the homozygous variant p.Leu387_ Gly395del in the VPS11 gene in two siblings. On immunoblotting, the mutant VPS11
PMID 27473128

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

Concepcion AR, Vaeth M, Wagner LE 2nd, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S.
The Journal of clinical investigation.J Clin Invest.2016 Oct 10. pii: 89056. doi: 10.1172/JCI89056. [Epub ahead of print]
Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyper
PMID 27721237

Reexcision Perineural Invasion and Epithelial Sheath Neuroma Possibly on a Spectrum of Postinjury Reactive Hyperplasia Mediated by IL-6.

Wang JY1, Nuovo G, Kline M, Magro CM.
The American Journal of dermatopathology.Am J Dermatopathol.2016 Oct 4. [Epub ahead of print]
Epithelial sheath neuroma is a rarely recognized but established entity in the medical literature. First described in 2000 by Requena et al, there have only been 7 published cases to date, mostly in female patients and presenting as symptomatic solitary lesions on the back without a known history of
PMID 27749287