Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/07 14:26:20」(JST)

wiki en

[Wiki en表示]

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.^[1]

Interactions

EIF4B has been shown to interact with EIF3A.^[2]

References

^ "Entrez Gene: EIF4B eukaryotic translation initiation factor 4B".
^ Méthot N, Song MS, Sonenberg N (Oct 1996). "A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3". Mol. Cell. Biol. 16 (10): 5328–34. PMC 231531. PMID 8816444.

External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

English Journal

MicroRNA‑216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.

Li L1, Ma HQ1.
Molecular medicine reports.Mol Med Rep.2015 Aug;12(2):3156-62. doi: 10.3892/mmr.2015.3761. Epub 2015 May 8.
There is increasing evidence to suggest that microRNAs (miRNAs; miRs) are involved in the development of oral squamous cell carcinoma (OSCC). miR‑216a has been identified as being involved in tumorigenesis, however, the mechanisms of miR‑216a in various types of cancer, either as a tumor suppres
PMID 25955794

ORF45-Mediated Prolonged c-Fos Accumulation Accelerates Viral Transcription during the Late Stage of Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.

Li X1, Du S2, Avey D3, Li Y2, Zhu F3, Kuang E4.
Journal of virology.J Virol.2015 Jul 1;89(13):6895-906. doi: 10.1128/JVI.00274-15. Epub 2015 Apr 22.
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes multiple viral proteins that activate extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) cascades. One of these viral proteins, ORF45, mediates sustained ERK-p90 ribosomal S6 kinase (RSK) activation during KSHV l
PMID 25903346

Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.

Fittschen M1, Lastres-Becker I, Halbach MV, Damrath E, Gispert S, Azizov M, Walter M, Müller S, Auburger G.
Neurogenetics.Neurogenetics.2015 Jul;16(3):181-92. doi: 10.1007/s10048-015-0441-5. Epub 2015 Feb 27.
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG-repeat expansion in the SCA2 gene, which encodes a polyglutamine (polyQ) domain expansion in ataxin-2 (ATXN2). ATXN2 is an RNA-binding protein and inter
PMID 25721894

Japanese Journal

Pim Kinase Substrate Identification and Specificity

Peng Charline,Knebel Axel,Morrice Nick A. [他],LI Xiang,BARRINGER Kevin,LI Jun,JAKES Scott,WERNEBURG Brian,WANG Lian
The journal of biochemistry 141(3), 353-362, 2007-03-01
NAID 10020100637

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

SHAHBAZIAN D.
EMBO J. 25, 2781-2791, 2006
NAID 30018420285

Related Pictures

Figure 3: Simplified summary of eukaryotic EIF4B (eukaryotic translation initiation Scanning, two ways. : A mechanistic methylguanosine moiety; (ii) eIF4B Figure 2. Interaction map of the the eif4b protein is regulated both by the mTOR signaling: At the crossroads of Figure 3 : mRNA helicases: the tacticians

★リンクテーブル★

リンク元	「eukaryotic initiation factor-4B」「真核生物翻訳開始因子4B」「eukaryotic translation initiation factor 4B」
関連記事	「eIF」

「eukaryotic initiation factor-4B」

Eukaryotic translation initiation factor 4B
	PDB rendering based on 1wi8.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1WI8, 2J76
Identifiers
Symbols	EIF4B ; EIF-4B; PRO1843
External IDs	OMIM: 603928 MGI: 95304 HomoloGene: 83162 GeneCards: EIF4B Gene
Gene ontology
Molecular function	• nucleotide binding; • RNA binding; • translation initiation factor activity; • protein binding; • poly(A) RNA binding;
Cellular component	• cytosol; • eukaryotic translation initiation factor 4F complex;
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; • nuclear-transcribed mRNA poly(A) tail shortening; • translation; • translational initiation; • regulation of translational initiation; • insulin receptor signaling pathway; • gene expression; • cellular protein metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;