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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/12 10:37:58」(JST)

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Eukaryotic translation initiation factor 1 is a protein that in humans is encoded by the EIF1 gene.^[1]^[2]^[3]

Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex. ^[4]

References

^ Fields C, Adams MD (Feb 1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochem Biophys Res Commun 198 (1): 288–91. DOI:10.1006/bbrc.1994.1040. PMID 7904817.
^ Sheikh MS, Fernandez-Salas E, Yu M, Hussain A, Dinman JD, Peltz SW, Huang Y, Fornace AJ Jr (Jul 1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1))". J Biol Chem 274 (23): 16487–93. DOI:10.1074/jbc.274.23.16487. PMID 10347211.
^ "Entrez Gene: EIF1 eukaryotic translation initiation factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10209.
^ Umadas Maitra, Jayanta Chaudhuri; Jayanta Chaudhuri, Kausik Si (21). "Function of Eukaryotic Translation Initiation Factor 1A (eIF1A) (Formerly Called eIF-4C) in Initiation of Protein Synthesis". The Journal of BIological Chemistry 272 (12): 7883–7891. DOI:10.1074/jbc.272.12.7883. http://www.jbc.org/content/272/12/7883.full.pdf+html. Retrieved 19 February 2012.

External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

English Journal

ABC50 mutants modify translation start codon selection.

Stewart JD1, Cowan JL1, Perry LS1, Coldwell MJ1, Proud CG1.
The Biochemical journal.Biochem J.2015 Apr 15;467(2):217-29. doi: 10.1042/BJ20141453.
ATP-binding cassette 50 (ABC50; also known as ABCF1) binds to eukaryotic initiation factor 2 (eIF2) and is required for efficient translation initiation. An essential step of this process is accurate recognition and selection of the initiation codon. It is widely accepted that the presence and movem
PMID 25597744

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.

Sinvani H1, Haimov O1, Svitkin Y2, Sonenberg N2, Tamarkin-Ben-Harush A1, Viollet B3, Dikstein R4.
Cell metabolism.Cell Metab.2015 Mar 3;21(3):479-92. doi: 10.1016/j.cmet.2015.02.010.
Protein synthesis is a major energy-consuming process, which is rapidly repressed upon energy stress by AMPK. How energy deficiency affects translation of mRNAs that cope with the stress response is poorly understood. We found that mitochondrial genes remain translationally active upon energy depriv
PMID 25738462

Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex.

Aylett CH1, Boehringer D1, Erzberger JP1, Schaefer T1, Ban N1.
Nature structural & molecular biology.Nat Struct Mol Biol.2015 Mar;22(3):269-71. doi: 10.1038/nsmb.2963. Epub 2015 Feb 9.
Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences
PMID 25664723

Japanese Journal

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

Cell Reports 18(11), 2651-2663, 2017-03-14
NAID 120006358788

着床前マウスセルトリクローン胚におけるEIF1Aのタンパク発現解析

Journal of mammalian ova research = 日本哺乳動物卵子学会誌 30(1), 41-45, 2013-04-01
NAID 10031166256

Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context

Journal of bioscience and bioengineering 109(6), 635-637, 2010-06-25
NAID 110007641913

Related Pictures

★リンクテーブル★

リンク元	「真核生物翻訳開始因子1」「eukaryotic initiation factor-1」「eukaryotic translation initiation factor 1」
関連記事	「eIF」

「真核生物翻訳開始因子1」

Eukaryotic translation initiation factor 1
	; PDB rendering based on 2if1.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2IF1
Identifiers
Symbols	EIF1; A121; EIF-1; EIF1A; ISO1; SUI1
External IDs	MGI: 3643981 HomoloGene: 48375 GeneCards: EIF1 Gene
Gene Ontology
Molecular function	• translation initiation factor activity; • translation factor activity, nucleic acid binding;
Cellular component	• cytoplasm;
Biological process	• translation; • translational initiation; • translational initiation; • regulation of translational initiation; • response to stress;
	Sources: Amigo / QuickGO
Orthologs
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