Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/22 22:22:56」(JST)

wiki en

Dyskaryosis. (dis-kār-ĭ-ó-sis). Abnormal cytologic changes of squamous epithelial cells characterized by hyperchromatic nuclei and/or irregular nuclear chromatin. Maybe followed by the development of a malignant neoplasm. Used synonymously with dysplasia, the more common term. Not to be confused with "dyskeratosis".

Term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which some of the epithelial cells near the external orifice show abnormalities in their cellular nuclei.

These changes are often quite subtle; often seen as temporary changes between the ages of fifteen and twenty-five. Apparent dyskaryosis below the age of twenty-five is not regarded as significant, and in many countries where cervical screening programmes exist, the age of entry into the programme is around that of twenty-five years old. The programme often terminates around the age of sixty-five, assuming no abnormal smears were found previously over a ten year period.

Cervical dyskaryosis is classified into three degrees of severity: mild, moderate and severe. A further category is used to define cells that do not show significant nuclear abnormality, and may not be described as 'dyskaryotic.' This category is termed [epithelial] cellular "borderline changes". As dyskaryotic epithelium found in the cervix have malignant potential, most cases of dyskaryosis will typically be followed up and referred. The risk is increasingly high with higher grades of dyskaryosis. Most borderline changes will resolve spontaneously, as will many mild ones. Moderate and severe changes are usually treated, by electrocautery, cryocautery or loop excision, with the objective of completely removing the abnormal area.

Dyskaryosis can be caused through infection with human papilloma virus (HPV), which exists in a number of different strains; type 16 and type 18 cause dyskaryosis more frequently and readily than do other types.^[1] These viruses are nearly always sexually transmitted. Immunization, which is now available against HPV 16 and 18, will prevent further infection by these strains. But if infection has occurred before immunization, and cellular change has already occurred, the vaccine does not reduce the risk of developing dyskaryotic change.

Dyskaryosis means abnormal nucleus and refers to the abnormal epithelial cell which may be found in cervical sample. It is graded from low to high grade based on degree of abnormality.all these changes are treatable with no recurrence

References

^ Clinical Evidence Concise, BMJ Publications^{[full citation needed]}

This article related to pathology is a stub. You can help Wikipedia by expanding it.

English Journal

Use of the ThinPrep Imaging System for internal quality control of cervical cytology.

Heard T, Chandra A, Culora G, Gupta SS, Herbert A, Morgan M.SourceGuys & St Thomas' NHS Foundation Trust, London, UK. tanya_heard@health.qld.gov.au
Cytopathology : official journal of the British Society for Clinical Cytology.Cytopathology.2013 Aug;24(4):246-53. doi: 10.1111/cyt.12010. Epub 2012 Sep 3.
OBJECTIVE: To audit the use of the ThinPrep Imaging System (TIS) for internal quality control (IQC) in the place of rapid review (RR), and to compare its performance with routine primary screening.METHOD: During 9 months, 16 462 ThinPrep slides were processed by TIS. Slides were initially review
PMID 22937891

Prospective parallel randomized trial of the MultiCyte™ ThinPrep(®) imaging system: the Scottish experience.

Palmer TJ, Nicoll SM, McKean ME, Park AJ, Bishop D, Baker L, Imrie JE.SourceDepartment of Pathology, Raigmore Hospital, Inverness, Scotland, UK. timothy.palmer@nhs.net
Cytopathology : official journal of the British Society for Clinical Cytology.Cytopathology.2013 Aug;24(4):235-45. doi: 10.1111/j.1365-2303.2012.00982.x. Epub 2012 May 22.
BACKGROUND: Computer-assisted screening of cervical liquid-based cytology (LBC) preparations using the ThinPrep® Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte™ has not been described in a well-established national screening programme with a low i
PMID 22616770

The role of cytological follow-up after radical vaginal trachelectomy for early-stage cervical cancer.

Edey K, Denton K, Murdoch J.SourceDepartment of Gynaecology, St Michael's Hospital, Bristol, UK.
Cytopathology : official journal of the British Society for Clinical Cytology.Cytopathology.2013 Jun 27. doi: 10.1111/cyt.12066. [Epub ahead of print]
OBJECTIVES: To identify whether recurrences were picked up by cytology alone after radical vaginal trachelectomy and to determine the false-positive rate of abnormal cytology.METHODS: Retrospective collection of patients from the cancer registry since radical vaginal trachelectomy was first performe
PMID 23802711

Japanese Journal

踵部に生じたclear cell eccrine carcinomaの1例

小池雅人,濱崎洋一郎,小川恩,嶋岡弥生,古谷野さとみ,堀江正樹,鈴木利宏,籏持淳,山崎雙次,泉美貴
Skin Cancer 23(3), 394-399, 2008
51歳, 男性。約7年前, 右足踵部内側に褐色の結節が出現し, 近医で切除した。2007年1月より同部位に紅色の結節が出現。急速に増大したため同年9月18日当科を受診した。初診時, 右足踵部内側に40×35×15mmの有茎性, 紅色腫瘤を認めた。腫瘤表面は潰瘍, 壊死を伴っていた。胸腹部CT, Gaシンチで転移を示唆する所見はなかった。10月1日に腫瘍辺縁より1cm離して, 一部筋膜を含め切除した …
NAID 130001078912