ジクロニン
- 関
- dyclonine hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/28 12:21:04」(JST)
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Dyclonine
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Systematic (IUPAC) name |
1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
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Clinical data |
Trade names |
Sucrets |
AHFS/Drugs.com |
monograph |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Legal status |
|
Routes of
administration |
Lozenge |
Identifiers |
CAS Number |
586-60-7 Y |
ATC code |
N01BX02 R02AD04 |
PubChem |
CID 3180 |
IUPHAR/BPS |
7173 |
DrugBank |
DB00645 Y |
ChemSpider |
3068 Y |
UNII |
078A24Q30O Y |
KEGG |
D07881 Y |
ChEBI |
CHEBI:4724 Y |
ChEMBL |
CHEMBL1201217 N |
Chemical data |
Formula |
C18H27NO2 |
Molar mass |
289.413 g/mol |
SMILES
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O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
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InChI
-
InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 Y
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Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N Y
|
NY (what is this?) (verify) |
Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge.[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.[2]
History
The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.[3]
In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.
References
- ^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. Retrieved 2011-09-24.
- ^ Gargiulo, A. V.; Burns, G. M.; Huck, C. P. (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois dental journal 61 (4): 303–304. PMID 1286862.
- ^ a b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24.
Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4 1/2-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik].
- ^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". Associated Press in the New York Times. April 19, 1966. Retrieved 2011-09-24.
External links
Throat preparations (R02)
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|
Antiseptics |
- Acriflavinium chloride
- Ambazone
- Amylmetacresol
- Benzalkonium
- Benzethonium
- Cetrimonium (bromide/chloride)
- Cetylpyridinium
- Chlorhexidine
- Chlorquinaldol
- Dequalinium
- Dichlorobenzyl alcohol
- Hexamidine
- Hexylresorcinol
- Myristyl-benzalkonium
- Oxyquinoline
- Phenol
- Povidone-iodine
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|
Antibiotics |
- Bacitracin
- Fusafungine
- Gramicidin
- Neomycin
- Tyrothricin
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Local anesthetics |
- Benzocaine
- Cocaine
- Dyclonine
- Lidocaine
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Other |
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Index of the respiratory system
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Description |
- Anatomy
- Physiology
- Development
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|
Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
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|
Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
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UpToDate Contents
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English Journal
- Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.
- Wu L, Liu J, Zhang Y, Hou Y.SourceHebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Mar 25;62:224-7. doi: 10.1016/j.jpba.2012.01.009. Epub 2012 Jan 16.
- A rapid and sensitive HPLC/MS/MS method was developed and validated for simultaneous determination of tinidazole, dyclonine and chlorhexidine, the three main components of a film-forming solution, in rat plasma. The plasma samples were pretreated by solid phase extraction (SPE) method. Separation wa
- PMID 22305084
- In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone).
- Kandasamy S, Sahu SK, Kandasamy K.SourceCentre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, India.
- ISRN dermatology.ISRN Dermatol.2012;2012:626214. Epub 2012 Sep 6.
- This work was to find out the dominant secondary metabolites derived from the fungus Trichoderma and to test them against skin cancer protein. The metabolites were extracted in 80% methanol from the fungal biomass of Trichoderma isolated from mangrove sediment. The crude methanol extract was purifie
- PMID 22991673
- Microneedle pretreatment improves efficacy of cutaneous topical anesthesia.
- Li X, Zhao R, Qin Z, Zhang J, Zhai S, Qiu Y, Gao Y, Xu B, Thomas SH.SourceDepartments of Pharmacy and Plastic Surgery, Peking University Third Hospital, Beijing 100083, China.
- The American journal of emergency medicine.Am J Emerg Med.2010 Feb;28(2):130-4. doi: 10.1016/j.ajem.2008.10.001.
- Methods to facilitate topical anesthesia for venipuncture are characterized by substantial limitations. This randomized double-blind study was undertaken to assess whether use of a quickly and painlessly applied microneedle system (functional microarray, FMA) to create punctures in the stratum corne
- PMID 20159380
Japanese Journal
- 泌尿器科学的内視鏡操作におけるEpirocain,Dyclonineの使用経験
- Epirocaine,Dyclonine複合剤による尿路粘膜表面麻酔の経験
- 表面麻酔剤Epirocain,Dyclonineの泌尿器科領域における使用経験
Related Links
- Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. [1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the ...
- dyclonine /dy·clo·nine/ (di´klo-nēn) a bactericidal and fungicidal local anesthetic, used topically as the hydrochloride salt. dyclonine [di´klo-nēn] ... Such agents include benzocaine, butamben, cocaine, dibucaine, lidocaine ...
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