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1. 妊婦管理：妊婦教育、健康管理、よく使う医薬品の安全性prenatal care patient education health promotion and safety of commonly used drugs [show details]
… influence both sleep position, sleep pattern, and stillbirth. Pregnant women tend to avoid this position when awake because of associated symptoms , but it appears that many spend some time sleeping supine .… versus not taking the drug, citing the best available evidence. Information on the use of specific drugs in pregnancy is available in the UpToDate drug database,…
2. 小児に生じる睡眠関連呼吸障害群の発症機序と素因mechanisms and predisposing factors for sleep related breathing disorders in children [show details]
… obstruction. Drug-induced sleep endoscopy (DISE) is a diagnostic tool to identify the site or sites of upper airway collapse that leads to OSA; the technique utilizes an anesthetic induction to simulate …
3. 正常な睡眠の段階および構造stages and architecture of normal sleep [show details]
… stages. Initial sleep staging was described in the 1930s, and formal rules for staging sleep were first propagated in 1968 . Since 2007, most sleep laboratories use terminology and scoring rules from the American …
4. 認知症患者における睡眠覚醒障害および睡眠障害sleep wake disturbances and sleep disorders in patients with dementia [show details]
… reports of worse sleep quality, which increase with age , have been linked to cellular aging . There is also an age-dependent increase in the prevalence of sleep disorders that may impact sleep quality and …
5. 入院中の睡眠不足：要因と介入poor sleep in the hospital contributing factors and interventions [show details]
… same class of drugs or used for a common effect can have differential effects on sleep. Beta blockers that do not cross the blood-brain barrier (eg, atenolol) have less risk of causing sleep disturbances …

English Journal

Neural inertia and differences between loss of and recovery from consciousness during total intravenous anaesthesia: a narrative review.

Sepúlveda PO, Tapia LF, Monsalves S.
Anaesthesia. 2019 Jun;74(6)801-809.
Most anaesthetists using target-controlled infusion systems will have observed that the calculated effect-site concentration at loss of consciousness is usually higher than the concentration at emergence. Inertia is the ability of biological systems to keep a functional state at rest or in activity
PMID 30835820

Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects.

Wrishko RE, McCrea JB, Yee KL, Liu W, Panebianco D, Mangin E, Chakravarthy M, Martinez-Cantarin MP, Kraft WK.
Clinical drug investigation. 2019 May;39(5)441-451.
Suvorexant is an orexin receptor antagonist indicated for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance. As suvorexant is metabolized primarily by Cytochrome P450 3A (CYP3A), and its pharmacokinetics may be affected by CYP3A modulators, the effect
PMID 30810914

Bioanalytical method to detect midazolam in plasma.

Dalla Costa BR, Anzolin AP, Rossato-Grando LG, Bertol CD.
Biomedical chromatography : BMC. 2019 Apr;()e4564.
Midazolam (MDZ) is the first choice in palliative sedation, and commonly used in sleep induction in anesthesia, with rapid onset of action. However, monitoring of the level of sedation in patients is not accurate. We developed and validated a bioanalytical method to detect MDZ in plasma using high-p
PMID 31041812

Japanese Journal

ASSR 検査における入眠導入時間と検査時間の検討

横田進,榎本英雄,安達のどか,浅沼聡,坂田英明
小児耳鼻咽喉科 32(1), 64-69, 2011
気導 ASSR（聴性定常反応）検査の効率的な運用を目指し，睡眠導入剤投与からの睡眠導入時間と検査時間および検査時間と難聴程度との関係を検討した。対象は睡眠導入時間，検査時間等の把握ができ，左右搬送周波数250 Hz, 500 Hz, 1 kHz, 2 kHz, 4 kHz すべてを測定できた患児144例，平均年齢4.1±3.4歳とした。ASSR 検査は Nav …
NAID 130004672217

An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice culture

Neuroscience Research 68(4), 315-321, 2010-12
… Non-ergot-type dopamine receptor agonists such as ropinirole are used for the treatment of Parkinson disease, but they occasionally show serious side effects including sleep attacks and daytime sleepiness. … These symptoms are reminiscent of narcolepsy, a major sleep disorder. … The decrease of orexin-immunoreactive neurons was reversible after washout of ropinirole and was not accompanied by induction of cell death. …
NAID 80021430682

重度けい直型四肢麻ひ児の睡眠障害に対するｔｉｚａｎｉｄｉｎｅ投与の効果

田中肇,福田郁江,宮本晶恵,岡隆治,長和彦,藤枝憲二
脳と発達 36(6), 455-460, 2004
重度痙直型四肢麻痺児の難治性睡眠障害に対して中枢性抗痙縮薬であるtizanidine (TZD) を用い, その有効性について検討した.<BR>睡眠障害を有する痙直型四肢麻痺児21名 (10カ月～21歳) を対象とし, TZD1日体重1kgあたり0.1～0.2mgを分2～分3投与した.この結果, 21名中13名 (61.9%) で少なからず睡眠障害の改善を認め, 一方で顔色不良となる副 …
NAID 130004183702