New pharmacological treatment strategies for relapse prevention.
Spanagel R, Vengeliene V.SourceInstitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, 68159 Mannheim, Germany. rainer.spanagel@zi-mannheim.de
Current topics in behavioral neurosciences.Curr Top Behav Neurosci.2013;13:583-609. doi: 10.1007/7854_2012_205.
Here we discuss treatment strategies that are based on pharmacological interventions to reduce craving and relapse in alcohol-dependent patients. We will first provide a historical overview about relapse prevention strategies. We will then review the development of disulfiram, naltrexone, acamprosat
New insight into hyperthermic intraperitoneal chemotherapy: induction of oxidative stress dramatically enhanced tumor killing in in vitro and in vivo models.
Lehmann K, Rickenbacher A, Jang JH, Oberkofler CE, Vonlanthen R, von Boehmer L, Humar B, Graf R, Gertsch P, Clavien PA.SourceLaboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Center, Department of Surgery, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland.
Annals of surgery.Ann Surg.2012 Nov;256(5):730-7; discussion 737-8. doi: 10.1097/SLA.0b013e3182737517.
BACKGROUND: The aim of hyperthermic intraperitoneal chemotherapy (HIPEC) is to eradicate microscopic residual tumor after radical surgical tumor excision in patients with peritoneal carcinomatosis. The common use of antineoplastic agents such as mitomycin C, doxorubicin, or oxaliplatin with hyperthe
Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies.
Conticello C, Martinetti D, Adamo L, Buccheri S, Giuffrida R, Parrinello N, Lombardo L, Anastasi G, Amato G, Cavalli M, Chiarenza A, De Maria R, Giustolisi R, Gulisano M, Di Raimondo F.SourceDepartment of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande, Italy.
International journal of cancer. Journal international du cancer.Int J Cancer.2012 Nov 1;131(9):2197-203. doi: 10.1002/ijc.27482. Epub 2012 Mar 27.
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholism. Here, we show that multiple myeloma (MM) cell lines and primary cells from newly diagnosed and relapsed/resistant patients affected by MM, acute myeloid and lymphoblastic leukemia are significantl
ditiocarb The sodium salt of diethyldithiocarbamate, a powerful ANTIOXIDANT and CHELATING drug that has been used to treat immune deficiency conditions, such as AIDS. It appears to be effective in reducing the incidence of ...