in a direful manner; "seeing himself trapped, he cried out direfully"
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恐ろしい,悲惨な
English Journal
Injectable biodegradable hydrogels from vitamin D-functionalized polycarbonates for the delivery of avastin with enhanced therapeutic efficiency against metastatic colorectal cancer.
Lee AL1, Ng VW, Gao S, Hedrick JL, Yang YY.
Biomacromolecules.Biomacromolecules.2015 Feb 9;16(2):465-75. doi: 10.1021/bm5015206. Epub 2015 Jan 16.
Humanized vascular endothelial growth factor (VEGF) antibody (bevacizumab; Avastin) is a highly effective monoclonal antibody against metastatic colorectal cancer and several other advanced late stage cancers. However, limited aqueous solubility and short circulation half-life of the antibody result
Definition of DIREFUL 1: dreadful <direful war began again — Charles Dickens> 2: ominous — dire · ful · ly \-fə-lē\ adverb See direful defined for kids ADVERTISEMENT Examples of DIREFUL <the stock market crash was the first direful ...