The involvement of P2Y12 receptors, NADPH oxidase, and lipid rafts in the action of extracellular ATP on synaptic transmission at the frog neuromuscular junction.
Giniatullin A1, Petrov A2, Giniatullin R3.
Neuroscience.Neuroscience.2015 Jan 29;285:324-32. doi: 10.1016/j.neuroscience.2014.11.039. Epub 2014 Nov 26.
Adenosine 5'-triphosphate (ATP) is the main co-transmitter accompanying the release of acetylcholine from motor nerve terminals. Previously, we revealed the direct inhibitory action of extracellular ATP on transmitter release via redox-dependent mechanism. However, the receptor mechanism of ATP acti
Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway.
Dong H1, Li R2, Yu C1, Xu T1, Zhang X1, Dong M3.
Neuroscience.Neuroscience.2015 Jan 29;285:70-80. doi: 10.1016/j.neuroscience.2014.11.008. Epub 2014 Nov 18.
Parkinson's disease (PD) is second only to Alzheimer's disease as the most common devastating human neurodegenerative disorder. Despite intense investigation, no curative therapy is available for PD. Paeoniflorin, a monoterpene glucoside isolated from the Paeonia lactiflora Pall., possesses wide pha
We report that particles of β-glucan, one of the surface components of yeasts, are powerful inducers of neutrophil extracellular trap (NET) formation in human neutrophils. β-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor
Oxidized High-Density Lipoprotein Induces the Proliferation and Migration of Vascular Smooth Muscle Cells by Promoting the Production of ROS
Wang Yan,Ji Liang,Jiang Rengui,Zheng Lemin,Liu Donghui
Journal of Atherosclerosis and Thrombosis 21(3), 204-216, 2014
… Diphenyleneiodonium chloride, an inhibitor of NADPH oxidase, and N-acetylcysteine, a ROS scavenger, efficiently inhibited the ROS production triggered by ox-HDL and subsequently blocked the proliferating and migrating effects of ox-HDL in the VSMCs.Conclusions: Ox-HDL significantly induces VSMC proliferation and migration by promoting NADPH oxidase activation and ROS production. …
Nicotine- and Tar-Free Cigarette Smoke Induces Cell Damage Through Reactive Oxygen Species Newly Generated by PKC-Dependent Activation of NADPH Oxidase
Journal of pharmacological sciences 118(2), 275-287, 2012-02-20
… Diphenyleneiodonium [NADPH oxidase (NOX) inhibitor] and bisindolylmaleimide I [BIS I, protein kinase C (PKC) inhibitor] abolished membrane damage, whereas they partially inhibited apoptosis. …
Buy Diphenyleneiodonium chloride (CAS 4673-26-1), an inhibitor of NOS2, NOS3, and NADPH oxidase, from Santa Cruz. Purity: ≥97%, MF: C12H8I•Cl ... Diphenyleneiodonium chloride has been shown to be a potent irreversible ...
1. Biochem Biophys Res Commun. 1998 Dec 18;253(2):295-9. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Li Y(1), Trush MA. Author ...