Dimethyltubocurarinium chloride (INN; also known as metocurine chloride (USAN) and dimethyltubocurarine chloride) is a non-depolarizing nicotinic acetylcholine receptor antagonist used as a muscle relaxant.
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Identification of residues in the adult nicotinic acetylcholine receptor that confer selectivity for curariform antagonists.
Bren N1, Sine SM.
The Journal of biological chemistry.J Biol Chem.1997 Dec 5;272(49):30793-8.
We identify residues in the epsilon and delta subunits of the adult nicotinic acetylcholine receptor that give the alphaepsilon and alphadelta binding sites different affinities for the curariform antagonist dimethyl d-tubocurarine (DMT). By constructing epsilon-delta subunit chimeras, coexpressing
Effect of hypothermia on the in vitro potencies of neuromuscular blocking agents and on their antagonism by neostigmine.
Aziz L1, Ono K, Ohta Y, Morita K, Hirakawa M.
British journal of anaesthesia.Br J Anaesth.1994 Nov;73(5):662-6.
The effect of temperature on the potencies of neuromuscular blocking agents remains unclear. This study was undertaken to examine the effects of different neuromuscular blocking agents at 37 and 27 degrees C at a constant carbon dioxide content (alpha stat principle). The effect of neostigmine 1 mum
Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions.
Fu DX1, Sine SM.
The Journal of biological chemistry.J Biol Chem.1994 Oct 21;269(42):26152-7.
We recently demonstrated that conserved tyrosines Tyr198 of the alpha subunit and Tyr117 of the gamma subunit of the acetylcholine receptor stabilize binding of the curariform antagonist dimethyl-d-tubocurarine (DMT). To test the hypothesis that DMT interacts directly with these tyrosines, and there
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